Angiotensin II Signal Transduction: An Update on Mechanisms of Physiology and Pathophysiology, Physiological Reviews | DeepDyve (2024)

Getting ready for building: signaling and autophagosome biogenesis

Abada, A; Elazar, Z

Identification and characterization of a functional mitochondrial angiotensin system

Abadir, PM; Foster, DB; Crow, M; Cooke, CA; Rucker, JJ; Jain, A; Smith, BJ; Burks, TN; Cohn, RD; Fedarko, NS; Carey, RM; O’Rourke, B; Walston, JD

Endothelial Microparticles From Acute Coronary Syndrome Patients Induce Premature Coronary Artery Endothelial Cell Aging and Thrombogenicity: Role of the Ang II/AT1 Receptor/NADPH Oxidase-Mediated Activation of MAPKs and PI3-Kinase Pathways

Abbas, M; Jesel, L; Auger, C; Amoura, L; Messas, N; Manin, G; Rumig, C; León-González, AJ; Ribeiro, TP; Silva, GC; Abou-Merhi, R; Hamade, E; Hecker, M; Georg, Y; Chakfe, N; Ohlmann, P; Schini-Kerth, VB; Toti, F; Morel, O

The angiotensin II AT2 receptor is an AT1 receptor antagonist

AbdAlla, S; Lother, H; Abdel-tawab, AM; Quitterer, U

AT1-receptor heterodimers show enhanced G-protein activation and altered receptor sequestration

AbdAlla, S; Lother, H; Quitterer, U

β-Arrestin mediates the Frank-Starling mechanism of cardiac contractility

Abraham, DM; Davis, RT; Warren, CM; Mao, L; Wolska, BM; Solaro, RJ; Rockman, HA

Renin receptor expression in human adipose tissue

Achard, V; Boullu-Ciocca, S; Desbriere, R; Nguyen, G; Grino, M

Expression and nutritional regulation of the (pro)renin receptor in rat visceral adipose tissue

Achard, V; Tassistro, V; Boullu-Ciocca, S; Grino, M

Role of Rac1 GTPase activation in atrial fibrillation

Adam, O; Frost, G; Custodis, F; Sussman, MA; Schäfers, HJ; Böhm, M; Laufs, U

Rac1-induced connective tissue growth factor regulates connexin 43 and N-cadherin expression in atrial fibrillation

Adam, O; Lavall, D; Theobald, K; Hohl, M; Grube, M; Ameling, S; Sussman, MA; Rosenkranz, S; Kroemer, HK; Schäfers, H-J; Böhm, M; Laufs, U

ET-1 from endothelial cells is required for complete angiotensin II-induced cardiac fibrosis and hypertrophy

Adiarto, S; Heiden, S; Vignon-Zellweger, N; Nakayama, K; Yagi, K; Yanagisawa, M; Emoto, N

The (Pro)renin receptor: site-specific and functional linkage to the vacuolar H+-ATPase in the kidney

Advani, A; Kelly, DJ; Cox, AJ; White, KE; Advani, SL; Thai, K; Connelly, KA; Yuen, D; Trogadis, J; Herzenberg, AM; Kuliszewski, MA; Leong-Poi, H; Gilbert, RE

Cullin-3 mutation causes arterial stiffness and hypertension through a vascular smooth muscle mechanism

Agbor, LN; Ibeawuchi, SC; Hu, C; Wu, J; Davis, DR; Keen, HL; Quelle, FW; Sigmund, CD

Upregulation of Nox4 by hypertrophic stimuli promotes apoptosis and mitochondrial dysfunction in cardiac myocytes

Ago, T; Kuroda, J; Pain, J; Fu, C; Li, H; Sadoshima, J

Angiotensin-(1-12): a chymase-mediated cellular angiotensin II substrate

Ahmad, S; Varagic, J; Groban, L; Dell’Italia, LJ; Nagata, S; Kon, ND; Ferrario, CM

Chymase mediates angiotensin-(1-12) metabolism in normal human hearts

Ahmad, S; Wei, CC; Tallaj, J; Dell’Italia, LJ; Moniwa, N; Varagic, J; Ferrario, CM

Angiotensin-converting enzyme gene polymorphism in overweight and obese Turkish patients with insulin resistance

Akin, F; Turgut, S; Bastemir, M; Turgut, G; Kursunluoglu, R; Karasu, U; Guclu, A

Binding of EBP50 to Nox organizing subunit p47phox is pivotal to cellular reactive species generation and altered vascular phenotype

Al Ghouleh, I; Meijles, DN; Mutchler, S; Zhang, Q; Sahoo, S; Gorelova, A; Henrich Amaral, J; Rodríguez, AI; Mamonova, T; Song, GJ; Bisello, A; Friedman, PA; Cifuentes-Pagano, ME; Pagano, PJ

Heme oxygenase-1 expression is down-regulated by angiotensin II and under hypertension in human neutrophils

Alba, G; El Bekay, R; Chacón, P; Reyes, ME; Ramos, E; Oliván, J; Jiménez, J; López, JM; Martín-Nieto, J; Pintado, E; Sobrino, F

Bcr kinase activation by angiotensin II inhibits PPARγ transcriptional activity in vascular smooth muscle cells

Alexis, JD; Wang, N; Che, W; Lerner-Marmarosh, N; Sahni, A; Korshunov, VA; Zou, Y; Ding, B; Yan, C; Berk, BC; Abe, J-i

Dependence on the motif YIPP for the physical association of Jak2 kinase with the intracellular carboxyl tail of the angiotensin II AT1 receptor

Ali, MS; Sayeski, PP; Dirksen, LB; Hayzer, DJ; Marrero, MB; Bernstein, KE

Angiotensin type 2 receptor null mice express reduced levels of renal angiotensin II type 2 receptor/angiotensin (1-7)/Mas receptor and exhibit greater high-fat diet-induced kidney injury

Ali, Q; Dhande, I; Samuel, P; Hussain, T

Integrin-linked kinase plays a key role in the regulation of angiotensin II-induced renal inflammation

Alique, M; Civantos, E; Sanchez-Lopez, E; Lavoz, C; Rayego-Mateos, S; Rodrigues-Díez, R; García-Redondo, AB; Egido, J; Ortiz, A; Rodríguez-Puyol, D; Rodríguez-Puyol, M; Ruiz-Ortega, M

Distribution of cells expressing human renin-promoter activity in the brain of a transgenic mouse

Allen, AM; O’Callaghan, EL; Hazelwood, L; Germain, S; Castrop, H; Schnermann, J; Bassi, JK

Localization and function of angiotensin AT1 receptors

Allen, AM; Zhuo, J; Mendelsohn, FA

Estradiol and angiotensin II crosstalk in hydromineral balance: Role of the ERK1/2 and JNK signaling pathways

Almeida-Pereira, G; Coletti, R; Mecawi, AS; Reis, LC; Elias, LLK; Antunes-Rodrigues, J

Deleting Vascular ADAM17 Sheds New Light on Hypertensive Cardiac Hypertrophy

Altara, R; Booz, GW

Cardiac STAT3 Deficiency Impairs Contractility and Metabolic Homeostasis in Hypertension

Altara, R; Harmancey, R; Didion, SP; Booz, GW; Zouein, FA

The NOX toolbox: validating the role of NADPH oxidases in physiology and disease

Altenhöfer, S; Kleikers, PW; Radermacher, KA; Scheurer, P; Rob Hermans, JJ; Schiffers, P; Ho, H; Wingler, K; Schmidt, HH

Angiotensin II impairs endothelial nitric-oxide synthase bioavailability under free cholesterol-enriched conditions via intracellular free cholesterol-rich membrane microdomains

Amiya, E; Watanabe, M; Takeda, N; Saito, T; Shiga, T; Hosoya, Y; Nakao, T; Imai, Y; Manabe, I; Nagai, R; Komuro, I; Maemura, K

Angiotensin II impairs the insulin signaling pathway promoting production of nitric oxide by inducing phosphorylation of insulin receptor substrate-1 on Ser312 and Ser616 in human umbilical vein endothelial cells

Andreozzi, F; Laratta, E; Sciacqua, A; Perticone, F; Sesti, G

TGF-β (Transforming Growth Factor-β) Signaling Protects the Thoracic and Abdominal Aorta From Angiotensin II-Induced Pathology by Distinct Mechanisms

Angelov, SN; Hu, JH; Wei, H; Airhart, N; Shi, M; Dichek, DA

Angiotensin II type 1 receptor blocker inhibits arterial calcification in a pre-clinical model

Armstrong, ZB; Boughner, DR; Drangova, M; Rogers, KA

The role of tissue Renin-Angiotensin-aldosterone system in the development of endothelial dysfunction and arterial stiffness

Aroor, AR; Demarco, VG; Jia, G; Sun, Z; Nistala, R; Meininger, GA; Sowers, JR

Therapeutic potential of the renin angiotensin system in ischaemic stroke

Arroja, MM; Reid, E; McCabe, C

Extracellular matrix, inflammation, and the angiogenic response

Arroyo, AG; Iruela-Arispe, ML

Angiotensin II enhances the increase in monocyte chemoattractant protein-1 production induced by tumor necrosis factor-alpha from 3T3-L1 preadipocytes

Asamizu, S; Urakaze, M; Kobashi, C; Ishiki, M; Norel Din, AK; Fujisaka, S; Kanatani, Y; Bukahari, A; Senda, S; Suzuki, H; Yamazaki, Y; Iwata, M; Usui, I; Yamazaki, K; Ogawa, H; Kobayashi, M; Tobe, K

No evidence for a local renin-angiotensin system in liver mitochondria

Astin, R; Bentham, R; Djafarzadeh, S; Horscroft, JA; Kuc, RE; Leung, PS; Skipworth, JR; Vicencio, JM; Davenport, AP; Murray, AJ; Takala, J; Jakob, SM; Montgomery, H; Szabadkai, G

Telomeres and aging

Aubert, G; Lansdorp, PM

Role of COX-2-derived PGE2 on vascular stiffness and function in hypertension

Avendaño, MS; Martínez-Revelles, S; Aguado, A; Simões, MR; González-Amor, M; Palacios, R; Guillem-Llobat, P; Vassallo, DV; Vila, L; García-Puig, J; Beltrán, LM; Alonso, MJ; Cachofeiro, MV; Salaices, M; Briones, AM

Genetically modified mouse models used for studying the role of the AT2 receptor in cardiac hypertrophy and heart failure

Avila, MD; Morgan, JP; Yan, X

Functional interaction between angiotensin II receptor type 1 and chemokine (C-C motif) receptor 2 with implications for chronic kidney disease

Ayoub, MA; Zhang, Y; Kelly, RS; See, HB; Johnstone, EK; McCall, EA; Williams, JH; Kelly, DJ; Pfleger, KD

Age- and Hypertension-Associated Protein Aggregates in Mouse Heart Have Similar Proteomic Profiles

Ayyadevara, S; Mercanti, F; Wang, X; Mackintosh, SG; Tackett, AJ; Prayaga, SV; Romeo, F; Shmookler Reis, RJ; Mehta, JL

NOX2-induced myocardial fibrosis and diastolic dysfunction: role of the endothelium

Bache, RJ; Chen, Y

Endoplasmic reticulum stress increases AT1R mRNA expression via TIA-1-dependent mechanism

Backlund, M; Paukku, K; Kontula, KK; Lehtonen, JY

ACE2, angiotensin-(1–7), and Mas: the other side of the coin

Bader, M

Cytoplasmic translocation of HuR contributes to angiotensin II induced cardiac fibrosis

Bai, D; Ge, L; Gao, Y; Lu, X; Wang, H; Yang, G

The smooth muscle-selective RhoGAP GRAF3 is a critical regulator of vascular tone and hypertension

Bai, X; Lenhart, KC; Bird, KE; Suen, AA; Rojas, M; Kakoki, M; Li, F; Smithies, O; Mack, CP; Taylor, JM

A century old renin-angiotensin system still grows with endless possibilities: AT1 receptor signaling cascades in cardiovascular physiopathology

Balakumar, P; Jagadeesh, G

Structural determinants for binding, activation, and functional selectivity of the angiotensin AT1 receptor

Balakumar, P; Jagadeesh, G

Oxidative stress causes renal angiotensin II type 1 receptor upregulation, Na+/H+ exchanger 3 overstimulation, and hypertension

Banday, AA; Lokhandwala, MF

Cardiac fibroblast-derived microRNA passenger strand-enriched exosomes mediate cardiomyocyte hypertrophy

Bang, C; Batkai, S; Dangwal, S; Gupta, SK; Foinquinos, A; Holzmann, A; Just, A; Remke, J; Zimmer, K; Zeug, A; Ponimaskin, E; Schmiedl, A; Yin, X; Mayr, M; Halder, R; Fischer, A; Engelhardt, S; Wei, Y; Schober, A; Fiedler, J; Thum, T

Matrix metalloproteinase-2 knockout prevents angiotensin II-induced vascular injury

Barhoumi, T; Fraulob-Aquino, JC; Mian, MOR; Ouerd, S; Idris-Khodja, N; Huo, KG; Rehman, A; Caillon, A; Dancose-Giambattisto, B; Ebrahimian, T; Lehoux, S; Paradis, P; Schiffrin, EL

T regulatory lymphocytes prevent angiotensin II-induced hypertension and vascular injury

Barhoumi, T; Kasal, DA; Li, MW; Shbat, L; Laurant, P; Neves, MF; Paradis, P; Schiffrin, EL

Dual inhibition of beta-adrenergic and angiotensin II receptors by a single antagonist: a functional role for receptor-receptor interaction in vivo

Barki-Harrington, L; Luttrell, LM; Rockman, HA

Angiotensin II mediates cell survival through upregulation and activation of the serum and glucocorticoid inducible kinase 1

Baskin, R; Sayeski, PP

NADPH oxidase 1 deficiency alters caveolin phosphorylation and angiotensin II-receptor localization in vascular smooth muscle

Basset, O; Deffert, C; Foti, M; Bedard, K; Jaquet, V; Ogier-Denis, E; Krause, KH

Loss of Timp3 gene leads to abdominal aortic aneurysm formation in response to angiotensin II

Basu, R; Fan, D; Kandalam, V; Lee, J; Das, SK; Wang, X; Baldwin, TA; Oudit, GY; Kassiri, Z

TIMP3 is the primary TIMP to regulate agonist-induced vascular remodelling and hypertension

Basu, R; Lee, J; Morton, JS; Takawale, A; Fan, D; Kandalam, V; Wang, X; Davidge, ST; Kassiri, Z

Notch transcriptional control of vascular smooth muscle regulatory gene expression and function

Basu, S; Srinivasan, DK; Yang, K; Raina, H; Banerjee, S; Zhang, R; Fisher, SA; Proweller, A

Rapid metabolism of exogenous angiotensin II by catecholaminergic neuronal cells in culture media

Basu, U; Seravalli, J; Madayiputhiya, N; Adamec, J; Case, AJ; Zimmerman, MC

Beta-catenin downregulation is required for adaptive cardiac remodeling

Baurand, A; Zelarayan, L; Betney, R; Gehrke, C; Dunger, S; Noack, C; Busjahn, A; Huelsken, J; Taketo, MM; Birchmeier, W; Dietz, R; Bergmann, MW

Central TrkB blockade attenuates ICV angiotensin II-hypertension and sympathetic nerve activity in male Sprague-Dawley rats

Becker, BK; Wang, H; Zucker, IH

BDNF contributes to angiotensin II-mediated reductions in peak voltage-gated K+ current in cultured CATH.a cells

Becker, BK; Wang, HJ; Tian, C; Zucker, IH

Dual agonist occupancy of AT1-R-α2C-AR heterodimers results in atypical Gs-PKA signaling

Bellot, M; Galandrin, S; Boularan, C; Matthies, HJ; Despas, F; Denis, C; Javitch, J; Mazères, S; Sanni, SJ; Pons, V; Seguelas, MH; Hansen, JL; Pathak, A; Galli, A; Sénard, JM; Galés, C

Loss of Jagged1 in renin progenitors leads to focal kidney fibrosis

Belyea, BC; Xu, F; Sequeira-Lopez, ML; Ariel Gomez, R

Pivotal role of a gp91(phox)-containing NADPH oxidase in angiotensin II-induced cardiac hypertrophy in mice

Bendall, JK; Cave, AC; Heymes, C; Gall, N; Shah, AM

Endothelial Nox2 overexpression potentiates vascular oxidative stress and hemodynamic response to angiotensin II: studies in endothelial-targeted Nox2 transgenic mice

Bendall, JK; Rinze, R; Adlam, D; Tatham, AL; de Bono, J; Channon, KM

Six commercially available angiotensin II AT1 receptor antibodies are non-specific

Benicky, J; Hafko, R; Sanchez-Lemus, E; Aguilera, G; Saavedra, JM

Disruption of the Ang II type 1 receptor promotes longevity in mice

Benigni, A; Corna, D; Zoja, C; Sonzogni, A; Latini, R; Salio, M; Conti, S; Rottoli, D; Longaretti, L; Cassis, P; Morigi, M; Coffman, TM; Remuzzi, G

Angiotensin II type 2 receptor deficiency aggravates renal injury and reduces survival in chronic kidney disease in mice

Benndorf, RA; Krebs, C; Hirsch-Hoffmann, B; Schwedhelm, E; Cieslar, G; Schmidt-Haupt, R; Steinmetz, OM; Meyer-Schwesinger, C; Thaiss, F; Haddad, M; Fehr, S; Heilmann, A; Helmchen, U; Hein, L; Ehmke, H; Stahl, RA; Böger, RH; Wenzel, UO

Vascular Smooth Muscle Cells in Atherosclerosis

Bennett, MR; Sinha, S; Owens, GK

Neuroprotective mechanisms of the ACE2-angiotensin-(1-7)-Mas axis in stroke

Bennion, DM; Haltigan, E; Regenhardt, RW; Steckelings, UM; Sumners, C

Activation of the Neuroprotective Angiotensin-Converting Enzyme 2 in Rat Ischemic Stroke

Bennion, DM; Haltigan, EA; Irwin, AJ; Donnangelo, LL; Regenhardt, RW; Pioquinto, DJ; Purich, DL; Sumners, C

Angiotensin type 2 receptor (AT2R): a challenging twin

Berk, BC

Integrin-linked kinase is a central mediator in angiotensin II type 1- and chemokine receptor CXCR4 signaling in myocardial hypertrophy

Bettink, SI; Werner, C; Chen, CH; Müller, P; Schirmer, SH; Walenta, KL; Böhm, M; Laufs, U; Friedrich, EB

Endothelium-specific interference with peroxisome proliferator activated receptor gamma causes cerebral vascular dysfunction in response to a high-fat diet

Beyer, AM; de Lange, WJ; Halabi, CM; Modrick, ML; Keen, HL; Faraci, FM; Sigmund, CD

Angiotensin II-induced arterial thickening, fibrosis and stiffening involves elevated arginase function

Bhatta, A; Yao, L; Toque, HA; Shatanawi, A; Xu, Z; Caldwell, RB; Caldwell, RW

Cross talk between AT1 receptors and Toll-like receptor 4 in microglia contributes to angiotensin II-derived ROS production in the hypothalamic paraventricular nucleus

Biancardi, VC; Stranahan, AM; Krause, EG; de Kloet, AD; Stern, JE

Residual cardiovascular risk in treated hypertension and hyperlipidaemia: the PRIME Study

Blacher, J; Evans, A; Arveiler, D; Amouyel, P; Ferrières, J; Bingham, A; Yarnell, J; Haas, B; Montaye, M; Ruidavets, JB; Ducimetière, P

Novel role of mechanosensitive AT1B receptors in myogenic vasoconstriction

Blodow, S; Schneider, H; Storch, U; Wizemann, R; Forst, AL; Gudermann, T; Mederos y Schnitzler, M

CD14 directs adventitial macrophage precursor recruitment: role in early abdominal aortic aneurysm formation

Blomkalns, AL; Gavrila, D; Thomas, M; Neltner, BS; Blanco, VM; Benjamin, SB; McCormick, ML; Stoll, LL; Denning, GM; Collins, SP; Qin, Z; Daugherty, A; Cassis, LA; Thompson, RW; Weiss, RM; Lindower, PD; Pinney, SM; Chatterjee, T; Weintraub, NL

Cardiorenal actions of TRV120027, a novel ß-arrestin-biased ligand at the angiotensin II type I receptor, in healthy and heart failure canines: a novel therapeutic strategy for acute heart failure

Boerrigter, G; Lark, MW; Whalen, EJ; Soergel, DG; Violin, JD; Burnett, JC

TRV120027, a novel β-arrestin biased ligand at the angiotensin II type I receptor, unloads the heart and maintains renal function when added to furosemide in experimental heart failure

Boerrigter, G; Soergel, DG; Violin, JD; Lark, MW; Burnett, JC

Acquisition of the contractile phenotype by murine arterial smooth muscle cells depends on the Mir143/145 gene cluster

Boettger, T; Beetz, N; Kostin, S; Schneider, J; Krüger, M; Hein, L; Braun, T

MicroRNA-29 in aortic dilation: implications for aneurysm formation

Boon, RA; Seeger, T; Heydt, S; Fischer, A; Hergenreider, E; Horrevoets, AJ; Vinciguerra, M; Rosenthal, N; Sciacca, S; Pilato, M; van Heijningen, P; Essers, J; Brandes, RP; Zeiher, AM; Dimmeler, S

Putting the brakes on cardiac hypertrophy: exploiting the NO-cGMP counter-regulatory system

Booz, GW

Involvement of protein kianse C and Ca2+ in angiotensin II-induced mitogenesis of cardiac fibroblasts

Booz, GW; Dostal, DE; Singer, HA; Baker, KM

The adipose tissue and the involvement of the renin-angiotensin-aldosterone system in cardiometabolic syndrome

Borghi, F; Sevá-Pessôa, B; Grassi-Kassisse, DM

Nox4 genetic inhibition in experimental hypertension and metabolic syndrome

Bouabout, G; Ayme-Dietrich, E; Jacob, H; Champy, MF; Birling, MC; Pavlovic, G; Madeira, L; Fertak, LE; Petit-Demoulière, B; Sorg, T; Herault, Y; Mudgett, J; Monassier, L

Angiotensin II and hypertonicity modulate proximal tubular aquaporin 1 expression

Bouley, R; Palomino, Z; Tang, SS; Nunes, P; Kobori, H; Lu, HA; Shum, WW; Sabolic, I; Brown, D; Ingelfinger, JR; Jung, FF

Notch3 is essential for regulation of the renal vascular tone

Boulos, N; Helle, F; Dussaule, JC; Placier, S; Milliez, P; Djudjaj, S; Guerrot, D; Joutel, A; Ronco, P; Boffa, JJ; Chatziantoniou, C

The angiotensin II type 2 receptor and improved adjacent region function post-MI

Bove, CM; Gilson, WD; Scott, CD; Epstein, FH; Yang, Z; Dimaria, JM; Berr, SS; French, BA; Bishop, SP; Kramer, CM

Nitric oxide mediates benefits of angiotensin II type 2 receptor overexpression during post-infarct remodeling

Bove, CM; Yang, Z; Gilson, WD; Epstein, FH; French, BA; Berr, SS; Bishop, SP; Matsubara, H; Carey, RM; Kramer, CM

Mutations in kelch-like 3 and cullin 3 cause hypertension and electrolyte abnormalities

Boyden, LM; Choi, M; Choate, KA; Nelson-Williams, CJ; Farhi, A; Toka, HR; Tikhonova, IR; Bjornson, R; Mane, SM; Colussi, G; Lebel, M; Gordon, RD; Semmekrot, BA; Poujol, A; Välimäki, MJ; De Ferrari, ME; Sanjad, SA; Gutkin, M; Karet, FE; Tucci, JR; Stockigt, JR; Keppler-Noreuil, KM; Porter, CC; Anand, SK; Whiteford, ML; Davis, ID; Dewar, SB; Bettinelli, A; Fadrowski, JJ; Belsha, CW; Hunley, TE; Nelson, RD; Trachtman, H; Cole, TR; Pinsk, M; Bockenhauer, D; Shenoy, M; Vaidyanathan, P; Foreman, JW; Rasoulpour, M; Thameem, F; Al-Shahrouri, HZ; Radhakrishnan, J; Gharavi, AG; Goilav, B; Lifton, RP

Mitochondrial NLRP3 protein induces reactive oxygen species to promote Smad protein signaling and fibrosis independent from the inflammasome

Bracey, NA; Gershkovich, B; Chun, J; Vilaysane, A; Meijndert, HC; Wright, JR; Fedak, PW; Beck, PL; Muruve, DA; Duff, HJ

Targeting the vasoprotective axis of the renin-angiotensin system: a novel strategic approach to pulmonary hypertensive therapy

Bradford, CN; Ely, DR; Raizada, MK

Interleukin 6 knockout prevents angiotensin II hypertension: role of renal vasoconstriction and janus kinase 2/signal transducer and activator of transcription 3 activation

Brands, MW; Banes-Berceli, AK; Inscho, EW; Al-Azawi, H; Allen, AJ; Labazi, H

Vascular inflammation and the renin-angiotensin system

Brasier, AR; Recinos, A; Eledrisi, MS

Regulation of signal transduction by reactive oxygen species in the cardiovascular system

Brown, DI; Griendling, KK

Contribution of aldosterone to cardiovascular and renal inflammation and fibrosis

Brown, NJ

Nomenclature for angiotensin receptors. A report of the Nomenclature Committee of the Council for High Blood Pressure Research

Bumpus, FM; Catt, KJ; Chiu, AT; DeGasparo, M; Goodfriend, T; Husain, A; Peach, MJ; Taylor, DG; Timmermans, PB

Elevated blood pressure and heart rate in human renin receptor transgenic rats

Burcklé, CA; Jan Danser, AH; Müller, DN; Garrelds, IM; Gasc, JM; Popova, E; Plehm, R; Peters, J; Bader, M; Nguyen, G

Endothelial microparticle formation by angiotensin II is mediated via Ang II receptor type I/NADPH oxidase/ Rho kinase pathways targeted to lipid rafts

Burger, D; Montezano, AC; Nishigaki, N; He, Y; Carter, A; Touyz, RM

Microparticles: biomarkers and beyond

Burger, D; Schock, S; Thompson, CS; Montezano, AC; Hakim, AM; Touyz, RM

Losartan restores skeletal muscle remodeling and protects against disuse atrophy in sarcopenia

Burks, TN; Andres-Mateos, E; Marx, R; Mejias, R; Van Erp, C; Simmers, JL; Walston, JD; Ward, CW; Cohn, RD

Atrial fibrosis: mechanisms and clinical relevance in atrial fibrillation

Burstein, B; Nattel, S

Contrasting roles of NADPH oxidase isoforms in pressure-overload versus angiotensin II-induced cardiac hypertrophy

Byrne, JA; Grieve, DJ; Bendall, JK; Li, JM; Gove, C; Lambeth, JD; Cave, AC; Shah, AM

γδ T Cells Mediate Angiotensin II-Induced Hypertension and Vascular Injury

Caillon, A; Mian, MOR; Fraulob-Aquino, JC; Huo, KG; Barhoumi, T; Ouerd, S; Sinnaeve, PR; Paradis, P; Schiffrin, EL

iPLA2β overexpression in smooth muscle exacerbates angiotensin II-induced hypertension and vascular remodeling

Calderon, LE; Liu, S; Su, W; Xie, Z; Guo, Z; Eberhard, W; Gong, MC

c-Src Inhibition Improves Cardiovascular Function but not Remodeling or Fibrosis in Angiotensin II-Induced Hypertension

Callera, GE; Antunes, TT; He, Y; Montezano, AC; Yogi, A; Savoia, C; Touyz, RM

Galectin-3 mediates aldosterone-induced vascular fibrosis

Calvier, L; Miana, M; Reboul, P; Cachofeiro, V; Martinez-Martinez, E; de Boer, RA; Poirier, F; Lacolley, P; Zannad, F; Rossignol, P; López-Andrés, N

A background Ca2+ entry pathway mediated by TRPC1/TRPC4 is critical for development of pathological cardiac remodelling

Camacho Londoño, JE; Tian, Q; Hammer, K; Schröder, L; Camacho Londoño, J; Reil, JC; He, T; Oberhofer, M; Mannebach, S; Mathar, I; Philipp, SE; Tabellion, W; Schweda, F; Dietrich, A; Kaestner, L; Laufs, U; Birnbaumer, L; Flockerzi, V; Freichel, M; Lipp, P

Determinants of Notch-3 receptor expression and signaling in vascular smooth muscle cells: implications in cell-cycle regulation

Campos, AH; Wang, W; Pollman, MJ; Gibbons, GH

DNA microarray profiling to identify angiotensin-responsive genes in vascular smooth muscle cells: potential mediators of vascular disease

Campos, AH; Zhao, Y; Pollman, MJ; Gibbons, GH

S1PR1 (Sphingosine-1-Phosphate Receptor 1) Signaling Regulates Blood Flow and Pressure

Cantalupo, A; Gargiulo, A; Dautaj, E; Liu, C; Zhang, Y; Hla, T; Di Lorenzo, A

Nogo-B regulates endothelial sphingolipid homeostasis to control vascular function and blood pressure

Cantalupo, A; Zhang, Y; Kothiya, M; Galvani, S; Obinata, H; Bucci, M; Giordano, FJ; Jiang, XC; Hla, T; Di Lorenzo, A

GPCR signaling and cardiac function

Capote, LA; Mendez Perez, R; Lymperopoulos, A

Angiotensin II activates the RhoA exchange factor Arhgef1 in humans

Carbone, ML; Brégeon, J; Devos, N; Chadeuf, G; Blanchard, A; Azizi, M; Pacaud, P; Jeunemaître, X; Loirand, G

MicroRNA-133 controls cardiac hypertrophy

Carè, A; Catalucci, D; Felicetti, F; Bonci, D; Addario, A; Gallo, P; Bang, ML; Segnalini, P; Gu, Y; Dalton, ND; Elia, L; Latronico, MV; Høydal, M; Autore, C; Russo, MA; Dorn, GW; Ellingsen, O; Ruiz-Lozano, P; Peterson, KL; Croce, CM; Peschle, C; Condorelli, G

Newly discovered components and actions of the renin-angiotensin system

Carey, RM

Superoxide dismutase 1 limits renal microvascular remodeling and attenuates arteriole and blood pressure responses to angiotensin II via modulation of nitric oxide bioavailability

Carlström, M; Lai, EY; Ma, Z; Steege, A; Patzak, A; Eriksson, UJ; Lundberg, JO; Wilcox, CS; Persson, AE

Recent progress on lipid lateral heterogeneity in plasma membranes: From rafts to submicrometric domains

Carquin, M; D’Auria, L; Pollet, H; Bongarzone, ER; Tyteca, D

Role of vascular smooth muscle PPARγ in regulating AT1 receptor signaling and angiotensin II-dependent hypertension

Carrillo-Sepulveda, MA; Keen, HL; Davis, DR; Grobe, JL; Sigmund, CD

Angiotensinogen gene silencing reduces markers of lipid accumulation and inflammation in cultured adipocytes

Carroll, WX; Kalupahana, NS; Booker, SL; Siriwardhana, N; Lemieux, M; Saxton, AM; Moustaid-Moussa, N

Local adipose tissue renin-angiotensin system

Cassis, LA; Police, SB; Yiannikouris, F; Thatcher, SE

Activation of the renal Na+:Cl- cotransporter by angiotensin II is a WNK4-dependent process

Castañeda-Bueno, M; Cervantes-Pérez, LG; Vázquez, N; Uribe, N; Kantesaria, S; Morla, L; Bobadilla, NA; Doucet, A; Alessi, DR; Gamba, G

Transcriptional regulator RBP-J regulates the number and plasticity of renin cells

Castellanos Rivera, RM; Monteagudo, MC; Pentz, ES; Glenn, ST; Gross, KW; Carretero, O; Sequeira-Lopez, ML; Gomez, RA

MiR-133a regulates collagen 1A1: potential role of miR-133a in myocardial fibrosis in angiotensin II-dependent hypertension

Castoldi, G; Di Gioia, CR; Bombardi, C; Catalucci, D; Corradi, B; Gualazzi, MG; Leopizzi, M; Mancini, M; Zerbini, G; Condorelli, G; Stella, A

Prevention of diabetic nephropathy by compound 21, selective agonist of angiotensin type 2 receptors, in Zucker diabetic fatty rats

Castoldi, G; di Gioia, CR; Bombardi, C; Maestroni, S; Carletti, R; Steckelings, UM; Dahlöf, B; Unger, T; Zerbini, G; Stella, A

Aldosterone and Left Ventricular Remodeling

Catena, C; Colussi, G; Brosolo, G; Novello, M; Sechi, LA

The angiotensin IV/AT4 receptor

Chai, SY; Fernando, R; Peck, G; Ye, SY; Mendelsohn, FA; Jenkins, TA; Albiston, AL

Angiotensin converting enzyme in rat brain visualized by quantitative in vitro autoradiography

Chai, SY; Mendelsohn, FA; Paxinos, G

Obligatory Role for B Cells in the Development of Angiotensin II-Dependent Hypertension

Chan, CT; Sobey, CG; Lieu, M; Ferens, D; Kett, MM; Diep, H; Kim, HA; Krishnan, SM; Lewis, CV; Salimova, E; Tipping, P; Vinh, A; Samuel, CS; Peter, K; Guzik, TJ; Kyaw, TS; Toh, BH; Bobik, A; Drummond, GR

Deficiency of Nox2 prevents angiotensin II-induced inward remodeling in cerebral arterioles

Chan, SL; Baumbach, GL

Epidermal growth factor receptor is critical for angiotensin II-mediated hypertrophy in cerebral arterioles

Chan, SL; Umesalma, S; Baumbach, GL

Angiotensin II type II receptor deficiency accelerates the development of nephropathy in type I diabetes via oxidative stress and ACE2

Chang, SY; Chen, YW; Chenier, I; Tran, SM; Zhang, SL

Angiotensin II in inflammation, immunity and rheumatoid arthritis

Chang, Y; Wei, W

Arterial Smooth Muscle Mitochondria Amplify Hydrogen Peroxide Microdomains Functionally Coupled to L-Type Calcium Channels

Chaplin, NL; Nieves-Cintrón, M; Fresquez, AM; Navedo, MF; Amberg, GC

Biochemical evaluation of the renin-angiotensin system: the good, bad, and absolute?

Chappell, MC

Emerging evidence for a functional angiotensin-converting enzyme 2-angiotensin-(1-7)-MAS receptor axis: more than regulation of blood pressure?

Chappell, MC

Analysis of p53 and NF-κB signaling in modulating the cardiomyocyte fate during hypertrophy

Chatterjee, A; Mir, SA; Dutta, D; Mitra, A; Pathak, K; Sarkar, S

Knockdown of mineralocorticoid or angiotensin II type 1 receptor gene expression in the paraventricular nucleus prevents angiotensin II hypertension in rats

Chen, A; Huang, BS; Wang, HW; Ahmad, M; Leenen, FH

Effects of Caenorhabditis elegans sgk-1 mutations on lifespan, stress resistance, and DAF-16/FoxO regulation

Chen, AT; Guo, C; Dumas, KJ; Ashrafi, K; Hu, PJ

Ubiquitin-activating enzyme E1 inhibitor PYR41 attenuates angiotensin II-induced activation of dendritic cells via the IκBa/NF-κB and MKP1/ERK/STAT1 pathways

Chen, C; Meng, Y; Wang, L; Wang, HX; Tian, C; Pang, GD; Li, HH; Du, J

TNFR1-deficient mice display altered blood pressure and renal responses to ANG II infusion

Chen, CC; Pedraza, PL; Hao, S; Stier, CT; Ferreri, NR

Impact of Angiotensin Type 1A Receptors in Principal Cells of the Collecting Duct on Blood Pressure and Hypertension

Chen, D; Stegbauer, J; Sparks, MA; Kohan, D; Griffiths, R; Herrera, M; Gurley, SB; Coffman, TM

Puerarin inhibits angiotensin II-induced cardiac hypertrophy via the redox-sensitive ERK1/2, p38 and NF-κB pathways

Chen, G; Pan, SQ; Shen, C; Pan, SF; Zhang, XM; He, QY

Age-Associated Sirtuin 1 Reduction in Vascular Smooth Muscle Links Vascular Senescence and Inflammation to Abdominal Aortic Aneurysm

Chen, HZ; Wang, F; Gao, P; Pei, JF; Liu, Y; Xu, TT; Tang, X; Fu, WY; Lu, J; Yan, YF; Wang, XM; Han, L; Zhang, ZQ; Zhang, R; Zou, MH; Liu, DP

Angiotensin II induces epithelial-to-mesenchymal transition in renal epithelial cells through reactive oxygen species/Src/caveolin-mediated activation of an epidermal growth factor receptor-extracellular signal-regulated kinase signaling pathway

Chen, J; Chen, JK; Harris, RC

EGFR signaling promotes TGFβ-dependent renal fibrosis

Chen, J; Chen, JK; Nagai, K; Plieth, D; Tan, M; Lee, TC; Threadgill, DW; Neilson, EG; Harris, RC

Loss of Smooth Muscle α-Actin Leads to NF-κB-Dependent Increased Sensitivity to Angiotensin II in Smooth Muscle Cells and Aortic Enlargement

Chen, J; Peters, A; Papke, CL; Villamizar, C; Ringuette, LJ; Cao, J; Wang, S; Ma, S; Gong, L; Byanova, KL; Xiong, J; Zhu, MX; Madonna, R; Kee, P; Geng, YJ; Brasier, AR; Davis, EC; Prakash, S; Kwartler, CS; Milewicz, DM

Angiotensin-Converting Enzyme in Smooth Muscle Cells Promotes Atherosclerosis-Brief Report

Chen, X; Howatt, DA; Balakrishnan, A; Moorleghen, JJ; Wu, C; Cassis, LA; Daugherty, A; Lu, H

Contributions of leukocyte angiotensin-converting enzyme to development of atherosclerosis

Chen, X; Lu, H; Zhao, M; Tashiro, K; Cassis, LA; Daugherty, A

TGF-β Neutralization Enhances AngII-Induced Aortic Rupture and Aneurysm in Both Thoracic and Abdominal Regions

Chen, X; Rateri, DL; Howatt, DA; Balakrishnan, A; Moorleghen, JJ; Cassis, LA; Daugherty, A

Pioglitazone inhibits angiotensin II-induced atrial fibroblasts proliferation via NF-κB/TGF-β1/TRIF/TRAF6 pathway

Chen, XQ; Liu, X; Wang, QX; Zhang, MJ; Guo, M; Liu, F; Jiang, WF; Zhou, L

Oxidative stress activates endothelial innate immunity via sterol regulatory element binding protein 2 (SREBP2) transactivation of microRNA-92a

Chen, Z; Wen, L; Martin, M; Hsu, CY; Fang, L; Lin, FM; Lin, TY; Geary, MJ; Geary, GG; Zhao, Y; Johnson, DA; Chen, JW; Lin, SJ; Chien, S; Huang, HD; Miller, YI; Huang, PH; Shyy, JY

Pharmacological inhibitor of notch signaling stabilizes the progression of small abdominal aortic aneurysm in a mouse model

Cheng, J; Koenig, SN; Kuivaniemi, HS; Garg, V; Hans, CP

MicroRNAs are aberrantly expressed in hypertrophic heart: do they play a role in cardiac hypertrophy?

Cheng, Y; Ji, R; Yue, J; Yang, J; Liu, X; Chen, H; Dean, DB; Zhang, C

PKC δ and βII regulate angiotensin II-mediated fibrosis through p38: a mechanism of RV fibrosis in pulmonary hypertension

Chichger, H; Vang, A; O’Connell, KA; Zhang, P; Mende, U; Harrington, EO; Choudhary, G

Caveolae, caveolins, and cavins: complex control of cellular signalling and inflammation

Chidlow, JH; Sessa, WC

Upregulation of the Na(+)-K(+)-2Cl(-) cotransporter 1 via histone modification in the aortas of angiotensin II-induced hypertensive rats

Cho, HM; Lee, DY; Kim, HY; Lee, HA; Seok, YM; Kim, IK

The microRNA miR-124 inhibits vascular smooth muscle cell proliferation by targeting S100 calcium-binding protein A4 (S100A4)

Choe, N; Kwon, DH; Shin, S; Kim, YS; Kim, YK; Kim, J; Ahn, Y; Eom, GH; Kook, H

Augmented S-nitrosylation contributes to impaired relaxation in angiotensin II hypertensive mouse aorta: role of thioredoxin reductase

Choi, H; Allahdadi, KJ; Tostes, RC; Webb, RC

The intercalated disk protein, mXinalpha, is capable of interacting with beta-catenin and bundling actin filaments

Choi, S; Gustafson-Wagner, EA; Wang, Q; Harlan, SM; Sinn, HW; Lin, JL; Lin, JJ

Targeted label-free quantitative analysis of secretory proteins from adipocytes in response to oxidative stress

Choi, S; Kim, J; Yea, K; Suh, PG; Kim, J; Ryu, SH

Preservation of myocardial fatty acid oxidation prevents diastolic dysfunction in mice subjected to angiotensin II infusion

Choi, YS; de Mattos, AB; Shao, D; Li, T; Nabben, M; Kim, M; Wang, W; Tian, R; Kolwicz, SC

Angiotensin II type 2 receptor (AT2R) in renal and cardiovascular disease

Chow, BS; Allen, TJ

Relaxin requires the angiotensin II type 2 receptor to abrogate renal interstitial fibrosis

Chow, BS; Kocan, M; Bosnyak, S; Sarwar, M; Wigg, B; Jones, ES; Widdop, RE; Summers, RJ; Bathgate, RA; Hewitson, TD; Samuel, CS

Quantitative phosphoproteomics dissection of seven-transmembrane receptor signaling using full and biased agonists

Christensen, GL; Kelstrup, CD; Lyngsø, C; Sarwar, U; Bøgebo, R; Sheikh, SP; Gammeltoft, S; Olsen, JV; Hansen, JL

Myeloperoxidase is increased in human cerebral aneurysms and increases formation and rupture of cerebral aneurysms in mice

Chu, Y; Wilson, K; Gu, H; Wegman-Points, L; Dooley, SA; Pierce, GL; Cheng, G; Pena Silva, RA; Heistad, DD; Hasan, D

Apelin signaling antagonizes Ang II effects in mouse models of atherosclerosis

Chun, HJ; Ali, ZA; Kojima, Y; Kundu, RK; Sheikh, AY; Agrawal, R; Zheng, L; Leeper, NJ; Pearl, NE; Patterson, AJ; Anderson, JP; Tsao, PS; Lenardo, MJ; Ashley, EA; Quertermous, T

Control of energy balance by the brain renin-angiotensin system

Claflin, KE; Grobe, JL

Angiotensin AT1A receptors on leptin receptor-expressing cells control resting metabolism

Claflin, KE; Sandgren, JA; Lambertz, AM; Weidemann, BJ; Littlejohn, NK; Burnett, CM; Pearson, NA; Morgan, DA; Gibson-Corley, KN; Rahmouni, K; Grobe, JL

miR-410 and miR-495 Are Dynamically Regulated in Diverse Cardiomyopathies and Their Inhibition Attenuates Pathological Hypertrophy

Clark, AL; Maruyama, S; Sano, S; Accorsi, A; Girgenrath, M; Walsh, K; Naya, FJ

Activation of the renin-angiotensin system, specifically in the subfornical organ is sufficient to induce fluid intake

Coble, JP; Cassell, MD; Davis, DR; Grobe, JL; Sigmund, CD

Mechanisms of brain renin angiotensin system-induced drinking and blood pressure: importance of the subfornical organ

Coble, JP; Grobe, JL; Johnson, AK; Sigmund, CD

Activity of protein kinase C-α within the subfornical organ is necessary for fluid intake in response to brain angiotensin

Coble, JP; Johnson, RF; Cassell, MD; Johnson, AK; Grobe, JL; Sigmund, CD

The inextricable role of the kidney in hypertension

Coffman, TM

Biogenesis, secretion, and intercellular interactions of exosomes and other extracellular vesicles

Colombo, M; Raposo, G; Théry, C

Lessons from in vitro studies and a related intracellular angiotensin II transgenic mouse model

Cook, JL; Re, RN

The trafficking protein GABARAP binds to and enhances plasma membrane expression and function of the angiotensin II type 1 receptor

Cook, JL; Re, RN; deHaro, DL; Abadie, JM; Peters, M; Alam, J

Dimorphic effects of transforming growth factor-β signaling during aortic aneurysm progression in mice suggest a combinatorial therapy for Marfan syndrome

Cook, JR; Clayton, NP; Carta, L; Galatioto, J; Chiu, E; Smaldone, S; Nelson, CA; Cheng, SH; Wentworth, BM; Ramirez, F

The senescence-associated secretory phenotype: the dark side of tumor suppression

Coppé, JP; Desprez, PY; Krtolica, A; Campisi, J

Angiotensin II induces the generation of procoagulant microparticles by human mononuclear cells via an angiotensin type 2 receptor-mediated pathway

Cordazzo, C; Neri, T; Petrini, S; Lombardi, S; Balìa, C; Cianchetti, S; Carmazzi, Y; Paggiaro, P; Pedrinelli, R; Celi, A

Full Expression of Cardiomyopathy Is Partly Dependent on B-Cells: A Pathway That Involves Cytokine Activation, Immunoglobulin Deposition, and Activation of Apoptosis

Cordero-Reyes, AM; Youker, KA; Trevino, AR; Celis, R; Hamilton, DJ; Flores-Arredondo, JH; Orrego, CM; Bhimaraj, A; Estep, JD; Torre-Amione, G

Cardiovascular effects of angiotensin A: a novel peptide of the renin-angiotensin system

Coutinho, DC; Foureaux, G; Rodrigues, KD; Salles, RL; Moraes, PL; Murça, TM; De Maria, ML; Gomes, ER; Santos, RA; Guatimosim, S; Ferreira, AJ

Soluble guanylyl cyclase is a target of angiotensin II-induced nitrosative stress in a hypertensive rat model

Crassous, PA; Couloubaly, S; Huang, C; Zhou, Z; Baskaran, P; Kim, DD; Papapetropoulos, A; Fioramonti, X; Durán, WN; Beuve, A

Recent advances involving the renin-angiotensin system

Crowley, SD; Coffman, TM

Angiotensin II causes hypertension and cardiac hypertrophy through its receptors in the kidney

Crowley, SD; Gurley, SB; Herrera, MJ; Ruiz, P; Griffiths, R; Kumar, AP; Kim, HS; Smithies, O; Le, TH; Coffman, TM

A role for angiotensin II type 1 receptors on bone marrow-derived cells in the pathogenesis of angiotensin II-dependent hypertension

Crowley, SD; Song, YS; Sprung, G; Griffiths, R; Sparks, M; Yan, M; Burchette, JL; Howell, DN; Lin, EE; Okeiyi, B; Stegbauer, J; Yang, Y; Tharaux, PL; Ruiz, P

Angiotensin II increases fibronectin and collagen I through the β-catenin-dependent signaling in mouse collecting duct cells

Cuevas, CA; Gonzalez, AA; Inestrosa, NC; Vio, CP; Prieto, MC

β-Catenin-Dependent Signaling Pathway Contributes to Renal Fibrosis in Hypertensive Rats

Cuevas, CA; Tapia-Rojas, C; Cespedes, C; Inestrosa, NC; Vio, CP

Orphan Nuclear Receptor Nur77 Inhibits Angiotensin II-Induced Vascular Remodeling via Downregulation of β-Catenin

Cui, M; Cai, Z; Chu, S; Sun, Z; Wang, X; Hu, L; Yi, J; Shen, L; He, B

ATRAP, novel AT1 receptor associated protein, enhances internalization of AT1 receptor and inhibits vascular smooth muscle cell growth

Cui, T; Nakagami, H; Iwai, M; Takeda, Y; Shiuchi, T; Tamura, K; Daviet, L; Horiuchi, M

Macrophages and Dendritic Cells: Partners in Atherogenesis

Cybulsky, MI; Cheong, C; Robbins, CS

The angiotensin II type 2 receptor causes constitutive growth of cardiomyocytes and does not antagonize angiotensin II type 1 receptor-mediated hypertrophy

D’Amore, A; Black, MJ; Thomas, WG

Suppression of adrenal βarrestin1-dependent aldosterone production by ARBs: head-to-head comparison

Dabul, S; Bathgate-Siryk, A; Valero, TR; Jafferjee, M; Sturchler, E; McDonald, P; Koch, WJ; Lymperopoulos, A

Cardiovascular morbidity and mortality in the Losartan Intervention For Endpoint reduction in hypertension study (LIFE): a randomised trial against atenolol

Dahlöf, B; Devereux, RB; Kjeldsen, SE; Julius, S; Beevers, G; de Faire, U; Fyhrquist, F; Ibsen, H; Kristiansson, K; Lederballe-Pedersen, O; Lindholm, LH; Nieminen, MS; Omvik, P; Oparil, S; Wedel, H

Mitochondrial targeted antioxidant Peptide ameliorates hypertensive cardiomyopathy

Dai, DF; Chen, T; Szeto, H; Nieves-Cintrón, M; Kutyavin, V; Santana, LF; Rabinovitch, PS

Mitochondrial oxidative stress mediates angiotensin II-induced cardiac hypertrophy and Galphaq overexpression-induced heart failure

Dai, DF; Johnson, SC; Villarin, JJ; Chin, MT; Nieves-Cintrón, M; Chen, T; Marcinek, DJ; Dorn, GW; Kang, YJ; Prolla, TA; Santana, LF; Rabinovitch, PS

p38 MAPK Inhibition Improves Synaptic Plasticity and Memory in Angiotensin II-dependent Hypertensive Mice

Dai, HL; Hu, WY; Jiang, LH; Li, L; Gaung, XF; Xiao, ZC

Targeting vascular (endothelial) dysfunction

Daiber, A; Steven, S; Weber, A; Shuvaev, VV; Muzykantov, VR; Laher, I; Li, H; Lamas, S; Münzel, T

Failure of adipocyte differentiation causes type II diabetes mellitus?

Danforth, E

Central blockade of TLR4 improves cardiac function and attenuates myocardial inflammation in angiotensin II-induced hypertension

Dange, RB; Agarwal, D; Masson, GS; Vila, J; Wilson, B; Nair, A; Francis, J

Regulation of angiotensin II actions by enhancers and super-enhancers in vascular smooth muscle cells

Das, S; Senapati, P; Chen, Z; Reddy, MA; Ganguly, R; Lanting, L; Mandi, V; Bansal, A; Leung, A; Zhang, S; Jia, Y; Wu, X; Schones, DE; Natarajan, R

Angiotensin II promotes atherosclerotic lesions and aneurysms in apolipoprotein E-deficient mice

Daugherty, A; Manning, MW; Cassis, LA

Genetic variants of the Renin Angiotensin system: effects on atherosclerosis in experimental models and humans

Daugherty, A; Poduri, A; Chen, X; Lu, H; Cassis, LA

Angiotensin II infusion promotes ascending aortic aneurysms: attenuation by CCR2 deficiency in apoE-/- mice

Daugherty, A; Rateri, DL; Charo, IF; Owens, AP; Howatt, DA; Cassis, LA

Mkk4 is a negative regulator of the transforming growth factor beta 1 signaling associated with atrial remodeling and arrhythmogenesis with age

Davies, L; Jin, J; Shen, W; Tsui, H; Shi, Y; Wang, Y; Zhang, Y; Hao, G; Wu, J; Chen, S; Fraser, JA; Dong, N; Christoffels, V; Ravens, U; Huang, CLH; Zhang, H; Cartwright, EJ; Wang, X; Lei, M

Smooth muscle cell deletion of low-density lipoprotein receptor-related protein 1 augments angiotensin II-induced superior mesenteric arterial and ascending aortic aneurysms

Davis, FM; Rateri, DL; Balakrishnan, A; Howatt, DA; Strickland, DK; Muratoglu, SC; Haggerty, CM; Fornwalt, BK; Cassis, LA; Daugherty, A

Abdominal aortic aneurysm: novel mechanisms and therapies

Davis, FM; Rateri, DL; Daugherty, A

Myofibroblasts: trust your heart and let fate decide

Davis, J; Molkentin, JD

Divergent functions of angiotensin II receptor isoforms in the brain

Davisson, RL; Oliverio, MI; Coffman, TM; Sigmund, CD

Hypertension: the missing WNKs

Dbouk, HA; Huang, CL; Cobb, MH

Plk1 regulates contraction of postmitotic smooth muscle cells and is required for vascular homeostasis

De Cárcer, G; Wachowicz, P; Martínez-Martínez, S; Oller, J; Méndez-Barbero, N; Escobar, B; González-Loyola, A; Takaki, T; El Bakkali, A; Cámara, JA; Jiménez-Borreguero, LJ; Bustelo, XR; Cañamero, M; Mulero, F; de Los Ángeles Sevilla, M; Montero, MJ; Redondo, JM; Malumbres, M

Vascular structure and oxidative stress in salt-loaded spontaneously hypertensive rats: effects of losartan and atenolol

De Cavanagh, EM; Ferder, LF; Ferder, MD; Stella, IY; Toblli, JE; Inserra, F

Angiotensin II blockade: a strategy to slow ageing by protecting mitochondria?

De Cavanagh, EM; Inserra, F; Ferder, L

Angiotensin II blockade: how its molecular targets may signal to mitochondria and slow aging. Coincidences with calorie restriction and mTOR inhibition

De Cavanagh, EM; Inserra, F; Ferder, L

International union of pharmacology. XXIII. The angiotensin II receptors

De Gasparo, M; Catt, KJ; Inagami, T; Wright, JW; Unger, T

The effect of angiotensin-converting enzyme inhibition using captopril on energy balance and glucose homeostasis

De Kloet, AD; Krause, EG; Kim, DH; Sakai, RR; Seeley, RJ; Woods, SC

Role of neurons and glia in the CNS actions of the renin-angiotensin system in cardiovascular control

De Kloet, AD; Liu, M; Rodríguez, V; Krause, EG; Sumners, C

Angiotensin type 1a receptors in the paraventricular nucleus of the hypothalamus protect against diet-induced obesity

De Kloet, AD; Pati, D; Wang, L; Hiller, H; Sumners, C; Frazier, CJ; Seeley, RJ; Herman, JP; Woods, SC; Krause, EG

Reporter mouse strain provides a novel look at angiotensin type-2 receptor distribution in the central nervous system

De Kloet, AD; Wang, L; Ludin, JA; Smith, JA; Pioquinto, DJ; Hiller, H; Steckelings, UM; Scheuer, DA; Sumners, C; Krause, EG

A Unique “Angiotensin-Sensitive” Neuronal Population Coordinates Neuroendocrine, Cardiovascular, and Behavioral Responses to Stress

De Kloet, AD; Wang, L; Pitra, S; Hiller, H; Smith, JA; Tan, Y; Nguyen, D; Cahill, KM; Sumners, C; Stern, JE; Krause, EG

Coordinating tissue interactions: Notch signaling in cardiac development and disease

De la Pompa, JL; Epstein, JA

Clinical perspectives and fundamental aspects of local cardiovascular and renal Renin-Angiotensin systems

De Mello, WC; Frohlich, ED

Direct evidence of intracrine angiotensin II signaling in neurons

Deliu, E; Brailoiu, GC; Eguchi, S; Hoffman, NE; Rabinowitz, JE; Tilley, DG; Madesh, M; Koch, WJ; Brailoiu, E

HDAC6 contributes to pathological responses of heart and skeletal muscle to chronic angiotensin-II signaling

Demos-Davies, KM; Ferguson, BS; Cavasin, MA; Mahaffey, JH; Williams, SM; Spiltoir, JI; Schuetze, KB; Horn, TR; Chen, B; Ferrara, C; Scellini, B; Piroddi, N; Tesi, C; Poggesi, C; Jeong, MY; McKinsey, TA

Conformational Profiling of the AT1 Angiotensin II Receptor Reflects Biased Agonism, G Protein Coupling, and Cellular Context

Devost, D; Sleno, R; Pétrin, D; Zhang, A; Shinjo, Y; Okde, R; Aoki, J; Inoue, A; Hébert, TE

Distinct roles of Nox1 and Nox4 in basal and angiotensin II-stimulated superoxide and hydrogen peroxide production

Dikalov, SI; Dikalova, AE; Bikineyeva, AT; Schmidt, HH; Harrison, DG; Griendling, KK

Angiotensin II-induced production of mitochondrial reactive oxygen species: potential mechanisms and relevance for cardiovascular disease

Dikalov, SI; Nazarewicz, RR

Nox2-induced production of mitochondrial superoxide in angiotensin II-mediated endothelial oxidative stress and hypertension

Dikalov, SI; Nazarewicz, RR; Bikineyeva, A; Hilenski, L; Lassègue, B; Griendling, KK; Harrison, DG; Dikalova, AE

Nox1 overexpression potentiates angiotensin II-induced hypertension and vascular smooth muscle hypertrophy in transgenic mice

Dikalova, A; Clempus, R; Lassègue, B; Cheng, G; McCoy, J; Dikalov, S; San Martin, A; Lyle, A; Weber, DS; Weiss, D; Taylor, WR; Schmidt, HH; Owens, GK; Lambeth, JD; Griendling, KK

Sirt3 Impairment and SOD2 Hyperacetylation in Vascular Oxidative Stress and Hypertension

Dikalova, AE; Itani, HA; Nazarewicz, RR; McMaster, WG; Flynn, CR; Uzhachenko, R; Fessel, JP; Gamboa, JL; Harrison, DG; Dikalov, SI

Cardiac microRNA-133 is down-regulated in thyroid hormone-mediated cardiac hypertrophy partially via Type 1 Angiotensin II receptor

Diniz, GP; Lino, CA; Guedes, EC; Moreira, LN; Barreto-Chaves, ML

Angiotensin II activates different calcium signaling pathways in adipocytes

Dolgacheva, LP; Turovskaya, MV; Dynnik, VV; Zinchenko, VP; Goncharov, NV; Davletov, B; Turovsky, EA

Angiotensin II induces renal plasminogen activator inhibitor-1 and cyclooxygenase-2 expression post-transcriptionally via activation of the mRNA-stabilizing factor human-antigen R

Doller, A; Gauer, S; Sobkowiak, E; Geiger, H; Pfeilschifter, J; Eberhardt, W

Characterization of Angiotensin II Molecular Determinants Involved in AT1 Receptor Functional Selectivity

Domazet, I; Holleran, BJ; Richard, A; Vandenberghe, C; Lavigne, P; Escher, E; Leduc, R; Guillemette, G

Modulation of the action of insulin by angiotensin-(1-7)

Dominici, FP; Burghi, V; Muñoz, MC; Giani, JF

Angiotensin-converting enzyme-2 overexpression improves left ventricular remodeling and function in a rat model of diabetic cardiomyopathy

Dong, B; Yu, QT; Dai, HY; Gao, YY; Zhou, ZL; Zhang, L; Jiang, H; Gao, F; Li, SY; Zhang, YH; Bian, HJ; Liu, CX; Wang, N; Xu, H; Pan, CM; Song, HD; Zhang, C; Zhang, Y

Molecular mechanisms of angiotensin II-mediated mitochondrial dysfunction: linking mitochondrial oxidative damage and vascular endothelial dysfunction

Doughan, AK; Harrison, DG; Dikalov, SI

Endothelial-specific Nox2 overexpression increases vascular superoxide and macrophage recruitment in ApoE−/− mice

Douglas, G; Bendall, JK; Crabtree, MJ; Tatham, AL; Carter, EE; Hale, AB; Channon, KM

Mutual antagonism between IP(3)RII and miRNA-133a regulates calcium signals and cardiac hypertrophy

Drawnel, FM; Wachten, D; Molkentin, JD; Maillet, M; Aronsen, JM; Swift, F; Sjaastad, I; Liu, N; Catalucci, D; Mikoshiba, K; Hisatsune, C; Okkenhaug, H; Andrews, SR; Bootman, MD; Roderick, HL

Angiotensin II Induces Skeletal Muscle Atrophy by Activating TFEB-Mediated MuRF1 Expression

Du Bois, P; Pablo Tortola, C; Lodka, D; Kny, M; Schmidt, F; Song, K; Schmidt, S; Bassel-Duby, R; Olson, EN; Fielitz, J

G-protein and tyrosine kinase receptor cross-talk in rat aortic smooth muscle cells: thrombin- and angiotensin II-induced tyrosine phosphorylation of insulin receptor substrate-1 and insulin-like growth factor 1 receptor

Du, J; Sperling, LS; Marrero, MB; Phillips, L; Delafontaine, P

Tumor necrosis factor: a mechanistic link between angiotensin-II-induced cardiac inflammation and fibrosis

Duerrschmid, C; Trial, J; Wang, Y; Entman, ML; Haudek, SB

The renin-angiotensin system, bone marrow and progenitor cells

Durik, M; Sevá Pessôa, B; Roks, AJ

Estimation of angiotensin II concentration in human plasma by radioimmunoassay. Some applications to physiological and clinical states

Düsterdieck, G; McElwee, G

Mitogen-activated protein kinase-activated protein kinase 2 in angiotensin II-induced inflammation and hypertension: regulation of oxidative stress

Ebrahimian, T; Li, MW; Lemarié, CA; Simeone, SM; Pagano, PJ; Gaestel, M; Paradis, P; Wassmann, S; Schiffrin, EL

Activation of MAPKs by angiotensin II in vascular smooth muscle cells. Metalloprotease-dependent EGF receptor activation is required for activation of ERK and p38 MAPK but not for JNK

Eguchi, S; Dempsey, PJ; Frank, GD; Motley, ED; Inagami, T

Metalloprotease-dependent ErbB ligand shedding in mediating EGFR transactivation and vascular remodelling

Eguchi, S; Frank, GD; Mifune, M; Inagami, T

Intracellular signaling of angiotensin II-induced p70 S6 kinase phosphorylation at Ser(411) in vascular smooth muscle cells. Possible requirement of epidermal growth factor receptor, Ras, extracellular signal-regulated kinase, and Akt

Eguchi, S; Iwasaki, H; Ueno, H; Frank, GD; Motley, ED; Eguchi, K; Marumo, F; Hirata, Y; Inagami, T

Calcium-dependent epidermal growth factor receptor transactivation mediates the angiotensin II-induced mitogen-activated protein kinase activation in vascular smooth muscle cells

Eguchi, S; Numaguchi, K; Iwasaki, H; Matsumoto, T; Yamakawa, T; Utsunomiya, H; Motley, ED; Kawakatsu, H; Owada, KM; Hirata, Y; Marumo, F; Inagami, T

Oxidative stress is a critical mediator of the angiotensin II signal in human neutrophils: involvement of mitogen-activated protein kinase, calcineurin, and the transcription factor NF-kappaB

El Bekay, R; Alvarez, M; Monteseirín, J; Alba, G; Chacón, P; Vega, A; Martin-Nieto, J; Jiménez, J; Pintado, E; Bedoya, FJ; Sobrino, F

Aortic valvular heart disease: Is there a place for angiotensin-converting-enzyme inhibitors?

Elder, DH; McAlpine-Scott, V; Choy, AM; Struthers, AD; Lang, CC

An integrative genome-wide transcriptome reveals that candesartan is neuroprotective and a candidate therapeutic for Alzheimer’s disease

Elkahloun, AG; Hafko, R; Saavedra, JM

ADAM17 silencing by adenovirus encoding miRNA-embedded siRNA revealed essential signal transduction by angiotensin II in vascular smooth muscle cells

Elliott, KJ; Bourne, AM; Takayanagi, T; Takaguri, A; Kobayashi, T; Eguchi, K; Eguchi, S

Lack of specificity of commercial antibodies leads to misidentification of angiotensin type-1 receptor protein

Elliott, KJ; Kimura, K; Eguchi, S

Evidence for a functional intracellular angiotensin system in the proximal tubule of the kidney

Ellis, B; Li, XC; Miguel-Qin, E; Gu, V; Zhuo, JL

Oxidative stress and abdominal aortic aneurysm: potential treatment targets

Emeto, TI; Moxon, JV; Au, M; Golledge, J

Brain-derived neurotrophic factor modulates angiotensin signaling in the hypothalamus to increase blood pressure in rats

Erdos, B; Backes, I; McCowan, ML; Hayward, LF; Scheuer, DA

Immunosuppression-Independent Role of Regulatory T Cells against Hypertension-Driven Renal Dysfunctions

Fabbiano, S; Menacho-Márquez, M; Robles-Valero, J; Pericacho, M; Matesanz-Marín, A; García-Macías, C; Sevilla, MA; Montero, MJ; Alarcón, B; López-Novoa, JM; Martín, P; Bustelo, XR

Nonclassical resident macrophages are important determinants in the development of myocardial fibrosis

Falkenham, A; de Antueno, R; Rosin, N; Betsch, D; Lee, TD; Duncan, R; Légaré, JF

Early fibroblast progenitor cell migration to the AngII-exposed myocardium is not CXCL12 or CCL2 dependent as previously thought

Falkenham, A; Sopel, M; Rosin, N; Lee, TD; Issekutz, T; Légaré, JF

Differential role of TIMP2 and TIMP3 in cardiac hypertrophy, fibrosis, and diastolic dysfunction

Fan, D; Takawale, A; Basu, R; Patel, V; Lee, J; Kandalam, V; Wang, X; Oudit, GY; Kassiri, Z

Cardiac fibroblasts, fibrosis and extracellular matrix remodeling in heart disease

Fan, D; Takawale, A; Lee, J; Kassiri, Z

A Disintegrin and Metalloprotease-17 Regulates Pressure Overload-Induced Myocardial Hypertrophy and Dysfunction Through Proteolytic Processing of Integrin β1

Fan, D; Takawale, A; Shen, M; Samokhvalov, V; Basu, R; Patel, V; Wang, X; Fernandez-Patron, C; Seubert, JM; Oudit, GY; Kassiri, Z

Endothelial cell-specific reactive oxygen species production increases susceptibility to aortic dissection

Fan, LM; Douglas, G; Bendall, JK; McNeill, E; Crabtree, MJ; Hale, AB; Mai, A; Li, JM; McAteer, MA; Schneider, JE; Choudhury, RP; Channon, KM

The renin-angiotensin system and the gastrointestinal mucosa

Fändriks, L

Perivascular macrophages mediate the neurovascular and cognitive dysfunction associated with hypertension

Faraco, G; Sugiyama, Y; Lane, D; Garcia-Bonilla, L; Chang, H; Santisteban, MM; Racchumi, G; Murphy, M; Van Rooijen, N; Anrather, J; Iadecola, C

Cardiovascular effects of the angiotensin type 2 receptor

Faria-Costa, G; Leite-Moreira, A; Henriques-Coelho, T

Modulation of glucose metabolism by the renin-angiotensin-aldosterone system

Favre, GA; Esnault, VL; Van Obberghen, E

MicroRNA Regulation of Atherosclerosis

Feinberg, MW; Moore, KJ

Unconventional hom*ologous internalization of the angiotensin II type-1 receptor induced by G-protein-independent signals

Feng, YH; Ding, Y; Ren, S; Zhou, L; Xu, C; Karnik, SS

Mechanisms of remodelling: a question of life (stem cell production) and death (myocyte apoptosis)

Ferrari, R; Ceconi, C; Campo, G; Cangiano, E; Cavazza, C; Secchiero, P; Tavazzi, L

Cardiac remodelling and RAS inhibition

Ferrario, CM

New physiological concepts of the renin-angiotensin system from the investigation of precursors and products of angiotensin I metabolism

Ferrario, CM

Intracrine angiotensin II functions originate from noncanonical pathways in the human heart

Ferrario, CM; Ahmad, S; Varagic, J; Cheng, CP; Groban, L; Wang, H; Collawn, JF; Dell'Italia, LJ

Therapeutic implications of the vasoprotective axis of the renin-angiotensin system in cardiovascular diseases

Ferreira, AJ; Santos, RA; Bradford, CN; Mecca, AP; Sumners, C; Katovich, MJ; Raizada, MK

Requirement of protein kinase D1 for pathological cardiac remodeling

Fielitz, J; Kim, M-S; Shelton, JM; Qi, X; Hill, JA; Richardson, JA; Bassel-Duby, R; Olson, EN

Caloric restriction ameliorates angiotensin II-induced mitochondrial remodeling and cardiac hypertrophy

Finckenberg, P; Eriksson, O; Baumann, M; Merasto, S; Lalowski, MM; Levijoki, J; Haasio, K; Kytö, V; Muller, DN; Luft, FC; Oresic, M; Mervaala, E

Signaling by the angiotensin-converting enzyme

Fleming, I

Plasminogen Activator Inhibitor Type I Controls Cardiomyocyte Transforming Growth Factor-β and Cardiac Fibrosis

Flevaris, P; Khan, SS; Eren, M; Schuldt, AJT; Shah, SJ; Lee, DC; Gupta, S; Shapiro, AD; Burridge, PW; Ghosh, AK; Vaughan, DE

Angiotensin II inhibits insulin signaling in aortic smooth muscle cells at multiple levels. A potential role for serine phosphorylation in insulin/angiotensin II crosstalk

Folli, F; Kahn, CR; Hansen, H; Bouchie, JL; Feener, EP

CTGF knockout does not affect cardiac hypertrophy and fibrosis formation upon chronic pressure overload

Fontes, MS; Kessler, EL; van Stuijvenberg, L; Brans, MA; Falke, LL; Kok, B; Leask, A; van Rijen, HV; Vos, MA; Goldschmeding, R; van Veen, TA

A CD31-derived peptide prevents angiotensin II-induced atherosclerosis progression and aneurysm formation

Fornasa, G; Clement, M; Groyer, E; Gaston, AT; Khallou-Laschet, J; Morvan, M; Guedj, K; Kaveri, SV; Tedgui, A; Michel, JB; Nicoletti, A; Caligiuri, G

Caveolin-1 Deletion Prevents Hypertensive Vascular Remodeling Induced by Angiotensin II

Forrester, SJ; Elliott, KJ; Kawai, T; Obama, T; Boyer, MJ; Preston, KJ; Yan, Z; Eguchi, S; Rizzo, V

Epidermal Growth Factor Receptor Transactivation: Mechanisms, Pathophysiology, and Potential Therapies in the Cardiovascular System

Forrester, SJ; Kawai, T; O’Brien, S; Thomas, W; Harris, RC; Eguchi, S

The angiotensin-converting enzyme 2/angiotensin-(1-7)/Mas receptor axis: a potential target for treating thrombotic diseases

Fraga-Silva, RA; Da Silva, DG; Montecucco, F; Mach, F; Stergiopulos, N; da Silva, RF; Santos, RA

Pathophysiological role of the renin-angiotensin system on erectile dysfunction

Fraga-Silva, RA; Montecucco, F; Mach, F; Santos, RA; Stergiopulos, N

Inflamm-aging. An evolutionary perspective on immunosenescence

Franceschi, C; Bonafè, M; Valensin, S; Olivieri, F; De Luca, M; Ottaviani, E; De Benedictis, G

Challenges and Opportunities in Linking Long Noncoding RNAs to Cardiovascular, Lung, and Blood Diseases

Freedman, JE; Miano, JM

Requirement of nuclear factor-kappaB in angiotensin II- and isoproterenol-induced cardiac hypertrophy in vivo

Freund, C; Schmidt-Ullrich, R; Baurand, A; Dunger, S; Schneider, W; Loser, P; El-Jamali, A; Dietz, R; Scheidereit, C; Bergmann, MW

Immune cell and other noncardiomyocyte regulation of cardiac hypertrophy and remodeling

Frieler, RA; Mortensen, RM

Vascular Smooth Muscle Sirtuin-1 Protects Against Aortic Dissection During Angiotensin II-Induced Hypertension

Fry, JL; Shiraishi, Y; Turcotte, R; Yu, X; Gao, YZ; Akiki, R; Bachschmid, M; Zhang, Y; Morgan, KG; Cohen, RA; Seta, F

The anti-adipogenic effect of angiotensin II on human preadipose cells involves ERK1,2 activation and PPARG phosphorylation

Fuentes, P; Acuña, MJ; Cifuentes, M; Rojas, CV

Blockade of the renin-angiotensin system increases adiponectin concentrations in patients with essential hypertension

Furuhashi, M; Ura, N; Higashiura, K; Murakami, H; Tanaka, M; Moniwa, N; Yoshida, D; Shimamoto, K

Blockade of the renin-angiotensin system decreases adipocyte size with improvement in insulin sensitivity

Furuhashi, M; Ura, N; Takizawa, H; Yoshida, D; Moniwa, N; Murakami, H; Higashiura, K; Shimamoto, K

Beta-arrestin- and dynamin-dependent endocytosis of the AT1 angiotensin receptor

Gáborik, Z; Szaszák, M; Szidonya, L; Balla, B; Paku, S; Catt, KJ; Clark, AJ; Hunyady, L

Angiotensin II-dependent TGF-β signaling contributes to Loeys-Dietz syndrome vascular pathogenesis

Gallo, EM; Loch, DC; Habashi, JP; Calderon, JF; Chen, Y; Bedja, D; van Erp, C; Gerber, EE; Parker, SJ; Sauls, K; Judge, DP; Cooke, SK; Lindsay, ME; Rouf, R; Myers, L; ap Rhys, CM; Kent, KC; Norris, RA; Huso, DL; Dietz, HC

Comparative expression analysis of the renin-angiotensin system components between white and brown perivascular adipose tissue

Gálvez-Prieto, B; Bolbrinker, J; Stucchi, P; de Las Heras, AI; Merino, B; Arribas, S; Ruiz-Gayo, M; Huber, M; Wehland, M; Kreutz, R; Fernandez-Alfonso, MS

Angiotensin AT1 receptor antagonism ameliorates murine retinal proteome changes induced by diabetes

Gao, B-B; Phipps, JA; Bursell, D; Clermont, AC; Feener, EP

Label-free quantitative analysis of one-dimensional PAGE LC/MS/MS proteome: application on angiotensin II-stimulated smooth muscle cells secretome

Gao, BB; Stuart, L; Feener, EP

Rosiglitzone suppresses angiotensin II-induced production of KLF5 and cell proliferation in rat vascular smooth muscle cells

Gao, D; Hao, G; Meng, Z; Ning, N; Yang, G; Liu, Z; Dong, X; Niu, X

Overexpression of SIRT1 in vascular smooth muscle cells attenuates angiotensin II-induced vascular remodeling and hypertension in mice

Gao, P; Xu, TT; Lu, J; Li, L; Xu, J; Hao, DL; Chen, HZ; Liu, DP

A Novel Systems-Biology Algorithm for the Analysis of Coordinated Protein Responses Using Quantitative Proteomics

García-Marqués, F; Trevisan-Herraz, M; Martínez-Martínez, S; Camafeita, E; Jorge, I; Lopez, JA; Méndez-Barbero, N; Méndez-Ferrer, S; Del Pozo, MA; Ibáñez, B; Andrés, V; Sánchez-Madrid, F; Redondo, JM; Bonzon-Kulichenko, E; Vázquez, J

NADPH oxidases and angiotensin II receptor signaling

Garrido, AM; Griendling, KK

Angiotensin II-induced changes of calcium sparks and ionic currents in human atrial myocytes: potential role for early remodeling in atrial fibrillation

Gassanov, N; Brandt, MC; Michels, G; Lindner, M; Er, F; Hoppe, UC

Decreased blood pressure in NOX1-deficient mice

Gavazzi, G; Banfi, B; Deffert, C; Fiette, L; Schappi, M; Herrmann, F; Krause, KH

NOX1 deficiency protects from aortic dissection in response to angiotensin II

Gavazzi, G; Deffert, C; Trocme, C; Schäppi, M; Herrmann, FR; Krause, KH

Angiotensin II-dependent hypertension causes reversible changes in the platelet proteome

Gebhard, S; Steil, L; Peters, B; Gesell-Salazar, M; Hammer, E; Kuttler, B; Clemetson, KJ; Scharf, C; Peters, J; Völker, U; Rettig, R; Greinacher, A

A functional siRNA screen identifies genes modulating angiotensin II-mediated EGFR transactivation

George, AJ; Purdue, BW; Gould, CM; Thomas, DW; Handoko, Y; Qian, H; Quaife-Ryan, GA; Morgan, KA; Simpson, KJ; Thomas, WG; Hannan, RD

Molecular basis and functional significance of Angiotensin II-induced increase in Discoidin Domain Receptor 2 gene expression in cardiac fibroblasts

George, M; Vijayakumar, A; Dhanesh, SB; James, J; Shivakumar, K

Irbesartan administration therapeutically influences circulating endothelial progenitor cell and microparticle mobilization by involvement of pro-inflammatory cytokines

Georgescu, A; Alexandru, N; Nemecz, M; Titorencu, I; Popov, D

The intrarenal generation of angiotensin II is required for experimental hypertension

Giani, JF; Shah, KH; Khan, Z; Bernstein, EA; Shen, XZ; McDonough, AA; Gonzalez-Villalobos, RA; Bernstein, KE

Vascular smooth muscle cell hypertrophy vs. hyperplasia. Autocrine transforming growth factor-beta 1 expression determines growth response to angiotensin II

Gibbons, GH; Pratt, RE; Dzau, VJ

Dopamine and angiotensin type 2 receptors cooperatively inhibit sodium transport in human renal proximal tubule cells

Gildea, JJ; Wang, X; Shah, N; Tran, H; Spinosa, M; Van Sciver, R; Sasaki, M; Yatabe, J; Carey, RM; Jose, PA; Felder, RA

Endothelial Cell Dysfunction and the Pathobiology of Atherosclerosis

Gimbrone, MA; García-Cardeña, G

MEF2 is regulated by CaMKIIδ2 and a HDAC4-HDAC5 heterodimer in vascular smooth muscle cells

Ginnan, R; Sun, LY; Schwarz, JJ; Singer, HA

NMDA Receptor Plasticity in the Hypothalamic Paraventricular Nucleus Contributes to the Elevated Blood Pressure Produced by Angiotensin II

Glass, MJ; Wang, G; Coleman, CG; Chan, J; Ogorodnik, E; Van Kempen, TA; Milner, TA; Butler, SD; Young, CN; Davisson, RL; Iadecola, C; Pickel, VM

Angiotensin II receptor blockade reduces tachycardia-induced atrial adhesion molecule expression

Goette, A; Bukowska, A; Lendeckel, U; Erxleben, M; Hammwöhner, M; Strugala, D; Pfeiffenberger, J; Röhl, FW; Huth, C; Ebert, MP; Klein, HU; Röcken, C

Increased expression of extracellular signal-regulated kinase and angiotensin-converting enzyme in human atria during atrial fibrillation

Goette, A; Staack, T; Röcken, C; Arndt, M; Geller, JC; Huth, C; Ansorge, S; Klein, HU; Lendeckel, U

Thoracic aortic aneurysm and dissection

Goldfinger, JZ; Halperin, JL; Marin, ML; Stewart, AS; Eagle, KA; Fuster, V

Angiotensin II-induced endothelial dysfunction is temporally linked with increases in interleukin-6 and vascular macrophage accumulation

Gomolak, JR; Didion, SP

Role of extracellular superoxide dismutase in hypertension

Gongora, MC; Qin, Z; Laude, K; Kim, HW; McCann, L; Folz, JR; Dikalov, S; f*ckai, T; Harrison, DG

Distribution of angiotensin type 1a receptor-containing cells in the brains of bacterial artificial chromosome transgenic mice

Gonzalez, AD; Wang, G; Waters, EM; Gonzales, KL; Speth, RC; Van Kempen, TA; Marques-Lopes, J; Young, CN; Butler, SD; Davisson, RL; Iadecola, C; Pickel, VM; Pierce, JP; Milner, TA

The emerging role of autophagy in the pathophysiology of diabetes mellitus

Gonzalez, CD; Lee, MS; Marchetti, P; Pietropaolo, M; Towns, R; Vaccaro, MI; Watada, H; Wiley, JW

Deletion of interleukin-6 prevents cardiac inflammation, fibrosis and dysfunction without affecting blood pressure in angiotensin II-high salt-induced hypertension

González, GE; Rhaleb, NE; D’Ambrosio, MA; Nakagawa, P; Liu, Y; Leung, P; Dai, X; Yang, XP; Peterson, EL; Carretero, OA

Angiotensin-II type 1 receptor (AT1R) and alpha-1D adrenoceptor form a heterodimer during pregnancy-induced hypertension

González-Hernández, ML; Godínez-Hernández, D; Bobadilla-Lugo, RA; López-Sánchez, P

Heterozygous disruption of activin receptor-like kinase 1 is associated with increased arterial pressure in mice

González-Núñez, M; Riolobos, AS; Castellano, O; Fuentes-Calvo, I; de los Ángeles Sevilla, M; Oujo, B; Pericacho, M; Cruz-Gonzalez, I; Pérez-Barriocanal, F; ten Dijke, P; López-Novoa, JM

The absence of intrarenal ACE protects against hypertension

Gonzalez-Villalobos, RA; Janjoulia, T; Fletcher, NK; Giani, JF; Nguyen, MT; Riquier-Brison, AD; Seth, DM; Fuchs, S; Eladari, D; Picard, N; Bachmann, S; Delpire, E; Peti-Peterdi, J; Navar, LG; Bernstein, KE; McDonough, AA

Angiotensin-converting enzyme-derived angiotensin II formation during angiotensin II-induced hypertension

Gonzalez-Villalobos, RA; Satou, R; Seth, DM; Semprun-Prieto, LC; Katsurada, A; Kobori, H; Navar, LG

Angiotensin II type I and prostaglandin F2α receptors cooperatively modulate signaling in vascular smooth muscle cells

Goupil, E; Fillion, D; Clément, S; Luo, X; Devost, D; Sleno, R; Pétrin, D; Saragovi, HU; Thorin, É; Laporte, SA; Hébert, TE

Update on new aspects of the renin-angiotensin system in liver disease: clinical implications and new therapeutic options

Grace, JA; Herath, CB; Mak, KY; Burrell, LM; Angus, PW

Angiotensin II stimulates NADH and NADPH oxidase activity in cultured vascular smooth muscle cells

Griendling, KK; Minieri, CA; Ollerenshaw, JD; Alexander, RW

Angiotensin II signaling in vascular smooth muscle. New concepts

Griendling, KK; Ushio-f*ckai, M; Lassègue, B; Alexander, RW

Low glial angiotensinogen improves body habitus, diastolic function, and exercise tolerance in aging male rats

Groban, L; Wang, H; Machado, FS; Trask, AJ; Kritchevsky, SB; Ferrario, CM; Diz, DI

The brain Renin-angiotensin system controls divergent efferent mechanisms to regulate fluid and energy balance

Grobe, JL; Grobe, CL; Beltz, TG; Westphal, SG; Morgan, DA; Xu, D; de Lange, WJ; Li, H; Sakai, K; Thedens, DR; Cassis, LA; Rahmouni, K; Mark, AL; Johnson, AK; Sigmund, CD

An intracellular renin-angiotensin system in neurons: fact, hypothesis, or fantasy

Grobe, JL; Xu, D; Sigmund, CD

Angiotensin II increases CTGF expression via MAPKs/TGF-β1/TRAF6 pathway in atrial fibroblasts

Gu, J; Liu, X; Wang, QX; Tan, HW; Guo, M; Jiang, WF; Zhou, L

The Rho exchange factor Arhgef1 mediates the effects of angiotensin II on vascular tone and blood pressure

Guilluy, C; Brégeon, J; Toumaniantz, G; Rolli-Derkinderen, M; Retailleau, K; Loufrani, L; Henrion, D; Scalbert, E; Bril, A; Torres, RM; Offermanns, S; Pacaud, P; Loirand, G

Development of hypertension and kidney hypertrophy in transgenic mice overexpressing ARAP1 gene in the kidney

Guo, DF; Chenier, I; Lavoie, JL; Chan, JS; Hamet, P; Tremblay, J; Chen, XM; Wang, DH; Inagami, T

Type 1 angiotensin II receptor-associated protein ARAP1 binds and recycles the receptor to the plasma membrane

Guo, DF; Chenier, I; Tardif, V; Orlov, SN; Inagami, T

A novel angiotensin II type 1 receptor-associated protein induces cellular hypertrophy in rat vascular smooth muscle and renal proximal tubular cells

Guo, DF; Tardif, V; Ghelima, K; Chan, JS; Ingelfinger, JR; Chen, X; Chenier, I

Role of angiotensin II type 1 receptor in angiotensin II-induced cytokine production in macrophages

Guo, F; Chen, XL; Wang, F; Liang, X; Sun, YX; Wang, YJ

AT1A angiotensin receptors in the renal proximal tubule regulate blood pressure

Gurley, SB; Riquier-Brison, ADM; Schnermann, J; Sparks, MA; Allen, AM; Haase, VH; Snouwaert, JN; Le, TH; McDonough, AA; Koller, BH; Coffman, TM

Role of the T cell in the genesis of angiotensin II induced hypertension and vascular dysfunction

Guzik, TJ; Hoch, NE; Brown, KA; McCann, LA; Rahman, A; Dikalov, S; Goronzy, J; Weyand, C; Harrison, DG

Angiotensin II type 2 receptor signaling attenuates aortic aneurysm in mice through ERK antagonism

Habashi, JP; Doyle, JJ; Holm, TM; Aziz, H; Schoenhoff, F; Bedja, D; Chen, Y; Modiri, AN; Judge, DP; Dietz, HC

Mineralocorticoid receptor blockade improves diastolic function independent of blood pressure reduction in a transgenic model of RAAS overexpression

Habibi, J; DeMarco, VG; Ma, L; Pulakat, L; Rainey, WE; Whaley-Connell, AT; Sowers, JR

Commercially available angiotensin II At2 receptor antibodies are nonspecific

Hafko, R; Villapol, S; Nostramo, R; Symes, A; Sabban, EL; Inagami, T; Saavedra, JM

Reciprocal interaction between macrophages and T cells stimulates IFN-γ and MCP-1 production in Ang II-induced cardiac inflammation and fibrosis

Han, YL; Li, YL; Jia, LX; Cheng, JZ; Qi, YF; Zhang, HJ; Du, J

Inhibition of Notch1 signaling reduces abdominal aortic aneurysm in mice by attenuating macrophage-mediated inflammation

Hans, CP; Koenig, SN; Huang, N; Cheng, J; Beceiro, S; Guggilam, A; Kuivaniemi, H; Partida-Sánchez, S; Garg, V

Effect of angiotensin-converting-enzyme inhibition compared with conventional therapy on cardiovascular morbidity and mortality in hypertension: the Captopril Prevention Project (CAPPP) randomised trial

Hansson, L; Lindholm, LH; Niskanen, L; Lanke, J; Hedner, T; Niklason, A; Luomanmäki, K; Dahlöf, B; de Faire, U; Mörlin, C; Karlberg, BE; Wester, PO; Björck, JE

Pressure overload induces cardiac hypertrophy in angiotensin II type 1A receptor knockout mice

Harada, K; Komuro, I; Shiojima, I; Hayashi, D; Kudoh, S; Mizuno, T; Kijima, K; Matsubara, H; Sugaya, T; Murakami, K; Yazaki, Y

Acute pressure overload could induce hypertrophic responses in the heart of angiotensin II type 1a knockout mice

Harada, K; Komuro, I; Zou, Y; Kudoh, S; Kijima, K; Matsubara, H; Sugaya, T; Murakami, K; Yazaki, Y

Transient receptor potential canonical-3 channel-dependent fibroblast regulation in atrial fibrillation

Harada, M; Luo, X; Qi, XY; Tadevosyan, A; Maguy, A; Ordog, B; Ledoux, J; Kato, T; Naud, P; Voigt, N; Shi, Y; Kamiya, K; Murohara, T; Kodama, I; Tardif, J-C; Schotten, U; Van Wagoner, DR; Dobrev, D; Nattel, S

Free radical theory of aging: an update: increasing the functional life span

Harman, D

Rapamycin fed late in life extends lifespan in genetically heterogeneous mice

Harrison, DE; Strong, R; Sharp, ZD; Nelson, JF; Astle, CM; Flurkey, K; Nadon, NL; Wilkinson, JE; Frenkel, K; Carter, CS; Pahor, M; Javors, MA; Fernandez, E; Miller, RA

Vascular Fibrosis in Aging and Hypertension: Molecular Mechanisms and Clinical Implications

Harvey, A; Montezano, AC; Lopes, RA; Rios, F; Touyz, RM

Smooth Muscle Peroxisome Proliferator-Activated Receptor γ Plays a Critical Role in Formation and Rupture of Cerebral Aneurysms in Mice In Vivo

Hasan, DM; Starke, RM; Gu, H; Wilson, K; Chu, Y; Chalouhi, N; Heistad, DD; Faraci, FM; Sigmund, CD

Monocytic fibroblast precursors mediate fibrosis in angiotensin-II-induced cardiac hypertrophy

Haudek, SB; Cheng, J; Du, J; Wang, Y; Hermosillo-Rodriguez, J; Trial, J; Taffet, GE; Entman, ML

Angiotensin peptides and their pleiotropic actions

Haulica, I; Bild, W; Serban, DN

Local bone marrow renin-angiotensin system in primitive, definitive and neoplastic haematopoiesis

Haznedaroglu, IC; Beyazit, Y

Activation of Na+/H+ exchanger NHE3 by angiotensin II is mediated by inositol 1,4,5-triphosphate (IP3) receptor-binding protein released with IP3 (IRBIT) and Ca2+/calmodulin-dependent protein kinase II

He, P; Klein, J; Yun, CC

The NHERF1 PDZ1 domain and IRBIT interact and mediate the activation of Na+/H+ exchanger 3 by ANG II

He, P; Zhao, L; No, YR; Karvar, S; Yun, CC

Atrial fibrillation induces myocardial fibrosis through angiotensin II type 1 receptor-specific Arkadia-mediated downregulation of Smad7

He, X; Gao, X; Peng, L; Wang, S; Zhu, Y; Ma, H; Lin, J; Duan, DD

Cardiomyocyte-specific expression of CYP2J2 prevents development of cardiac remodelling induced by angiotensin II

He, Z; Zhang, X; Chen, C; Wen, Z; Hoopes, SL; Zeldin, DC; Wang, DW

Prevention of atrial fibrillation with angiotensin-converting enzyme inhibitors and angiotensin receptor blockers: a meta-analysis

Healey, JS; Baranchuk, A; Crystal, E; Morillo, CA; Garfinkle, M; Yusuf, S; Connolly, SJ

Angiotensin II induces transactivation of two different populations of the platelet-derived growth factor beta receptor. Key role for the p66 adaptor protein Shc

Heeneman, S; Haendeler, J; Saito, Y; Ishida, M; Berk, BC

Disruption of vascular Ca2+-activated chloride currents lowers blood pressure

Heinze, C; Seniuk, A; Sokolov, MV; Huebner, AK; Klementowicz, AE; Szijártó, IA; Schleifenbaum, J; Vitzthum, H; Gollasch, M; Ehmke, H; Schroeder, BC; Hübner, CA

Interventions to slow cardiovascular aging: Dietary restriction, drugs and novel molecules

Heiss, C; Spyridopoulos, I; Haendeler, J

The role of the renin-angiotensin system in the development of insulin resistance in skeletal muscle

Henriksen, EJ; Prasannarong, M

Angiotensin II-mediated oxidative DNA damage accelerates cellular senescence in cultured human vascular smooth muscle cells via telomere-dependent and independent pathways

Herbert, KE; Mistry, Y; Hastings, R; Poolman, T; Niklason, L; Williams, B

Murine pressure overload models: a 30-MHz look brings a whole new “sound” into data interpretation

Hermans, H; Swinnen, M; Pokreisz, P; Caluwé, E; Dymarkowski, S; Herregods, MC; Janssens, S; Herijgers, P

Local Renin-Angiotensin system in the reproductive system

Herr, D; Bekes, I; Wulff, C

Lack of specificity of commercial antibodies leads to misidentification of angiotensin type 1 receptor protein

Herrera, M; Sparks, MA; Alfonso-Pecchio, AR; Harrison-Bernard, LM; Coffman, TM

Oxidative stress and endothelial dysfunction: clinical evidence and therapeutic implications

Higashi, Y; Maruhashi, T; Noma, K; Kihara, Y

Angiotensin II signal transduction through the AT1 receptor: novel insights into mechanisms and pathophysiology

Higuchi, S; Ohtsu, H; Suzuki, H; Shirai, H; Frank, GD; Eguchi, S

Increased PDZ-RhoGEF/RhoA/Rho kinase signaling in small mesenteric arteries of angiotensin II-induced hypertensive rats

Hilgers, RH; Todd, J; Webb, RC

Angiotensin type 1a receptors in the subfornical organ are required for deoxycorticosterone acetate-salt hypertension

Hilzendeger, AM; Cassell, MD; Davis, DR; Stauss, HM; Mark, AL; Grobe, JL; Sigmund, CD

A brain leptin-renin angiotensin system interaction in the regulation of sympathetic nerve activity

Hilzendeger, AM; Morgan, DA; Brooks, L; Dellsperger, D; Liu, X; Grobe, JL; Rahmouni, K; Sigmund, CD; Mark, AL

Physiological roles for the subfornical organ: a dynamic transcriptome shaped by autonomic state

Hindmarch, CC; Ferguson, AV

p21-activated kinase 1 participates in vascular remodeling in vitro and in vivo

Hinoki, A; Kimura, K; Higuchi, S; Eguchi, K; Takaguri, A; Ishimaru, K; Frank, GD; Gerthoffer, WT; Sommerville, LJ; Autieri, MV; Eguchi, S

Serum angiotensin-converting enzyme 2 concentration and angiotensin-(1-7) concentration in patients with acute heart failure patients requiring emergency hospitalization

Hisatake, S; Kiuchi, S; Kabuki, T; Oka, T; Dobashi, S; Ikeda, T

Sodium sensing in the subfornical organ and body-fluid homeostasis

Hiyama, TY; Noda, M

Regulation of T-cell function by endogenously produced angiotensin II

Hoch, NE; Guzik, TJ; Chen, W; Deans, T; Maalouf, SA; Gratze, P; Weyand, C; Harrison, DG

G Protein-coupled Receptor Biased Agonism

Hodavance, SY; Gareri, C; Torok, RD; Rockman, HA

Endothelial Bmx tyrosine kinase activity is essential for myocardial hypertrophy and remodeling

Holopainen, T; Räsänen, M; Anisimov, A; Tuomainen, T; Zheng, W; Tvorogov, D; Hulmi, JJ; Andersson, LC; Cenni, B; Tavi, P; Mervaala, E; Kivelä, R; Alitalo, K

Angiotensin II Type 1 Receptor Mechanoactivation Involves RGS5 (Regulator of G Protein Signaling 5) in Skeletal Muscle Arteries: Impaired Trafficking of RGS5 in Hypertension

Hong, K; Li, M; Nourian, Z; Meininger, GA; Hill, MA

The WNK kinase network regulating sodium, potassium, and blood pressure

Hoorn, EJ; Nelson, JH; McCormick, JA; Ellison, DH

Role of angiotensin II receptor subtype activation in cognitive function and ischaemic brain damage

Horiuchi, M; Mogi, M

Obesity-induced hepatic steatosis is mediated by endoplasmic reticulum stress in the subfornical organ of the brain

Horwath, JA; Hurr, C; Butler, SD; Guruju, M; Cassell, MD; Mark, AL; Davisson, RL; Young, CN

Inflammation and metabolic disorders

Hotamisligil, GS

Leukocyte Calpain Deficiency Reduces Angiotensin II-Induced Inflammation and Atherosclerosis But Not Abdominal Aortic Aneurysms in Mice

Howatt, DA; Balakrishnan, A; Moorleghen, JJ; Muniappan, L; Rateri, DL; Uchida, HA; Takano, J; Saido, TC; Chishti, AH; Baud, L; Subramanian, V

A complex microworld in the gut: gut microbiota and cardiovascular disease connectivity

Howitt, MR; Garrett, WS

Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespan

Howitz, KT; Bitterman, KJ; Cohen, HY; Lamming, DW; Lavu, S; Wood, JG; Zipkin, RE; Chung, P; Kisielewski, A; Zhang, LL; Scherer, B; Sinclair, DA

Retinol-binding protein 7 is an endothelium-specific PPARγ cofactor mediating an antioxidant response through adiponectin

Hu, C; Keen, HL; Lu, KT; Liu, X; Wu, J; Davis, DR; Ibeawuchi, SC; Vogel, S; Quelle, FW; Sigmund, CD

Interference with PPARγ in endothelium accelerates angiotensin II-induced endothelial dysfunction

Hu, C; Lu, KT; Mukohda, M; Davis, DR; Faraci, FM; Sigmund, CD

ANG II promotes IGF-IIR expression and cardiomyocyte apoptosis by inhibiting HSF1 via JNK activation and SIRT1 degradation

Huang, CY; Kuo, WW; Yeh, YL; Ho, TJ; Lin, JY; Lin, DY; Chu, CH; Tsai, FJ; Tsai, CH; Huang, CY

miR-34a modulates angiotensin II-induced myocardial hypertrophy by direct inhibition of ATG9A expression and autophagic activity

Huang, J; Sun, W; Huang, H; Ye, J; Pan, W; Zhong, Y; Cheng, C; You, X; Liu, B; Xiong, L; Liu, S

Angiotensin-converting enzyme-induced activation of local angiotensin signaling is required for ascending aortic aneurysms in fibulin-4-deficient mice

Huang, J; Yamashiro, Y; Papke, CL; Ikeda, Y; Lin, Y; Patel, M; Inagami, T; Le, VP; Wagenseil, JE; Yanagisawa, H

Smad3 mediates cardiac inflammation and fibrosis in angiotensin II-induced hypertensive cardiac remodeling

Huang, XR; Chung, AC; Yang, F; Yue, W; Deng, C; Lau, CP; Tse, HF; Lan, HY

Hypoxia-inducible factor-1α in vascular smooth muscle regulates blood pressure homeostasis through a peroxisome proliferator-activated receptor-γ-angiotensin II receptor type 1 axis

Huang, Y; Di Lorenzo, A; Jiang, W; Cantalupo, A; Sessa, WC; Giordano, FJ

Cardiac-specific Traf2 overexpression enhances cardiac hypertrophy through activating AKT/GSK3β signaling

Huang, Y; Wu, D; Zhang, X; Jiang, M; Hu, C; Lin, J; Tang, J; Wu, L

Activation of the (pro)renin receptor in the paraventricular nucleus increases sympathetic outflow in anesthetized rats

Huber, MJ; Basu, R; Cecchettini, C; Cuadra, AE; Chen, QH; Shan, Z

A novel small molecule TLR4 antagonist (IAXO-102) negatively regulates non-hematopoietic toll like receptor 4 signalling and inhibits aortic aneurysms development

Huggins, C; Pearce, S; Peri, F; Neumann, F; co*ckerill, G; Pirianov, G

Diabetic cardiomyopathy: mechanisms and new treatment strategies targeting antioxidant signaling pathways

Huynh, K; Bernardo, BC; McMullen, JR; Ritchie, RH

Hypertension-causing Mutations in Cullin3 Protein Impair RhoA Protein Ubiquitination and Augment the Association with Substrate Adaptors

Ibeawuchi, SR; Agbor, LN; Quelle, FW; Sigmund, CD

Angiotensin II type 2 receptor is essential for left ventricular hypertrophy and cardiac fibrosis in chronic angiotensin II-induced hypertension

Ichihara, S; Senbonmatsu, T; Price, E; Ichiki, T; Gaffney, FA; Inagami, T

Regulation of angiotensin II receptor expression

Ichiki, T

Deletion of NF-κB/RelA in Angiotensin II-Sensitive Mesenchymal Cells Blocks Aortic Vascular Inflammation and Abdominal Aortic Aneurysm Formation

Ijaz, T; Sun, H; Pinchuk, IV; Milewicz, DM; Tilton, RG; Brasier, AR

Biased Agonism of the Angiotensin II Type I Receptor

Ikeda, Y; Kumagai, H; Motozawa, Y; Suzuki, J; Komuro, I

Smooth muscle cell-specific Hif-1α deficiency suppresses angiotensin II-induced vascular remodelling in mice

Imanishi, M; Tomita, S; Ishizawa, K; Kihira, Y; Ueno, M; Izawa-Ishizawa, Y; Ikeda, Y; Yamano, N; Tsuchiya, K; Tamaki, T

Continuous activation of renin-angiotensin system impairs cognitive function in renin/angiotensinogen transgenic mice

Inaba, S; Iwai, M; Furuno, M; Tomono, Y; Kanno, H; Senba, I; Okayama, H; Mogi, M; Higaki, J; Horiuchi, M

Attenuation of ligand-induced activation of angiotensin II type 1 receptor signaling by the type 2 receptor via protein kinase C

Inuzuka, T; Fujioka, Y; Tsuda, M; Fujioka, M; Satoh, AO; Horiuchi, K; Nishide, S; Nanbo, A; Tanaka, S; Ohba, Y

Angiotensin II type 1 receptor expression in astrocytes is upregulated leading to increased mortality in mice with myocardial infarction-induced heart failure

Isegawa, K; Hirooka, Y; Katsuki, M; Kishi, T; Sunagawa, K

Critical role of monocyte chemoattractant protein-1 receptor CCR2 on monocytes in hypertension-induced vascular inflammation and remodeling

Ishibashi, M; Hiasa, K; Zhao, Q; Inoue, S; Ohtani, K; Kitamoto, S; Tsuchihashi, M; Sugaya, T; Charo, IF; Kura, S; Tsuzuki, T; Ishibashi, T; Takesh*ta, A; Egashira, K

Angiotensin II type 1 receptor: relationship with caveolae and caveolin after initial agonist stimulation

Ishizaka, N; Griendling, KK; Lassègue, B; Alexander, RW

Thoracic and abdominal aortic aneurysms

Isselbacher, EM

Mitochondrial Cyclophilin D in Vascular Oxidative Stress and Hypertension

Itani, HA; Dikalova, AE; McMaster, WG; Nazarewicz, RR; Bikineyeva, AT; Harrison, DG; Dikalov, SI

Activation of Human T Cells in Hypertension: Studies of Humanized Mice and Hypertensive Humans

Itani, HA; McMaster, WG; Saleh, MA; Nazarewicz, RR; Mikolajczyk, TP; Kaszuba, AM; Konior, A; Prejbisz, A; Januszewicz, A; Norlander, AE; Chen, W; Bonami, RH; Marshall, AF; Poffenberger, G; Weyand, CM; Madhur, MS; Moore, DJ; Harrison, DG; Guzik, TJ

CD70 Exacerbates Blood Pressure Elevation and Renal Damage in Response to Repeated Hypertensive Stimuli

Itani, HA; Xiao, L; Saleh, MA; Wu, J; Pilkinton, MA; Dale, BL; Barbaro, NR; Foss, JD; Kirabo, A; Montaniel, KR; Norlander, AE; Chen, W; Sato, R; Navar, LG; Mallal, SA; Madhur, MS; Bernstein, KE; Harrison, DG

Identification of the Mtus1 Splice Variant as a Novel Inhibitory Factor Against Cardiac Hypertrophy

Ito, S; Asakura, M; Liao, Y; Min, KD; Takahashi, A; Shindo, K; Yamazaki, S; Tsukamoto, O; Asanuma, H; Mogi, M; Horiuchi, M; Asano, Y; Sanada, S; Minamino, T; Takashima, S; Mochizuki, N; Kitakaze, M

Atrial fibrillation pathophysiology: implications for management

Iwasaki, YK; Nishida, K; Kato, T; Nattel, S

Transgenic Mice Overexpressing Human Angiotensin I Receptor Gene Are Susceptible to Stroke Injury

Jain, S; Tulsulkar, J; Rana, A; Kumar, A; Shah, ZA

Stimulation of angiotensin type 1A receptors on catecholaminergic cells contributes to angiotensin-dependent hypertension

Jancovski, N; Bassi, JK; Carter, DA; Choong, YT; Connelly, A; Nguyen, TP; Chen, D; Lukoshkova, EV; Menuet, C; Head, GA; Allen, AM

Mass-spectrometric identification of a novel angiotensin peptide in human plasma

Jankowski, V; Vanholder, R; van der Giet, M; Tölle, M; Karadogan, S; Gobom, J; Furkert, J; Oksche, A; Krause, E; Tran, TN; Tepel, M; Schuchardt, M; Schlüter, H; Wiedon, A; Beyermann, M; Bader, M; Todiras, M; Zidek, W; Jankowski, J

Mice lacking angiotensin-converting enzyme have increased energy expenditure, with reduced fat mass and improved glucose clearance

Jayasooriya, AP; Mathai, ML; Walker, LL; Begg, DP; Denton, DA; Cameron-Smith, D; Egan, GF; McKinley, MJ; Rodger, PD; Sinclair, AJ; Wark, JD; Weisinger, HS; Jois, M; Weisinger, RS

Cytochrome P450 1B1 contributes to angiotensin II-induced hypertension and associated pathophysiology

Jennings, BL; Sahan-Firat, S; Estes, AM; Das, K; Farjana, N; Fang, XR; Gonzalez, FJ; Malik, KU

Loss of Resistance to Angiotensin II-Induced Hypertension in the Jackson Laboratory Recombination-Activating Gene Null Mouse on the C57BL/6J Background

Ji, H; Pai, AV; West, CA; Wu, X; Speth, RC; Sandberg, K

Sex-specific T-cell regulation of angiotensin II-dependent hypertension

Ji, H; Zheng, W; Li, X; Liu, J; Wu, X; Zhang, MA; Umans, JG; Hay, M; Speth, RC; Dunn, SE; Sandberg, K

The ubiquitin E3 ligase TRAF6 exacerbates pathological cardiac hypertrophy via TAK1-dependent signalling

Ji, YX; Zhang, P; Zhang, XJ; Zhao, YC; Deng, KQ; Jiang, X; Wang, PX; Huang, Z; Li, H

Role of interferon regulatory factor 4 in the regulation of pathological cardiac hypertrophy

Jiang, DS; Bian, ZY; Zhang, Y; Zhang, SM; Liu, Y; Zhang, R; Chen, Y; Yang, Q; Zhang, XD; Fan, GC; Li, H

Interferon regulatory factor 7 functions as a novel negative regulator of pathological cardiac hypertrophy

Jiang, DS; Liu, Y; Zhou, H; Zhang, Y; Zhang, XD; Zhang, XF; Chen, K; Gao, L; Peng, J; Gong, H; Chen, Y; Yang, Q; Liu, PP; Fan, GC; Zou, Y; Li, H

Signal regulatory protein-α protects against cardiac hypertrophy via the disruption of toll-like receptor 4 signaling

Jiang, DS; Zhang, XF; Gao, L; Zong, J; Zhou, H; Liu, Y; Zhang, Y; Bian, ZY; Zhu, LH; Fan, GC; Zhang, XD; Li, H

Identification of Amino Acid Residues in Angiotensin II Type 1 Receptor Sensing Mechanical Stretch and Function in Cardiomyocyte Hypertrophy

Jiang, G; Gong, H; Niu, Y; Yang, C; Wang, S; Chen, Z; Ye, Y; Zhou, N; Zhang, G; Ge, J; Zou, Y

Increased aortic calpain-1 activity mediates age-associated angiotensin II signaling of vascular smooth muscle cells

Jiang, L; Wang, M; Zhang, J; Monticone, RE; Telljohann, R; Spinetti, G; Pintus, G; Lakatta, EG

Calmodulin-dependent protein kinase II/cAMP response element-binding protein/Wnt/β-catenin signaling cascade regulates angiotensin II-induced podocyte injury and albuminuria

Jiang, L; Xu, L; Song, Y; Li, J; Mao, J; Zhao, AZ; He, W; Yang, J; Dai, C

Losartan reverses the down-expression of long noncoding RNA-NR024118 and Cdkn1c induced by angiotensin II in adult rat cardiac fibroblasts

Jiang, X; Zhang, F; Ning, Q

Expression profiling of long noncoding RNAs and the dynamic changes of lncRNA-NR024118 and Cdkn1c in angiotensin II-treated cardiac fibroblasts

Jiang, XY; Ning, QL

Small RNA sequencing reveals microRNAs that modulate angiotensin II effects in vascular smooth muscle cells

Jin, W; Reddy, MA; Chen, Z; Putta, S; Lanting, L; Kato, M; Park, JT; Chandra, M; Wang, C; Tangirala, RK; Natarajan, R

Effect of angiotensin II type 2 receptor-interacting protein on adipose tissue function via modulation of macrophage polarization

Jing, F; Mogi, M; Min, L-J; Ohshima, K; Nakaoka, H; Tsukuda, K; Wang, X; Iwanami, J; Horiuchi, M

Brain endoplasmic reticulum stress mechanistically distinguishes the saline-intake and hypertensive response to deoxycorticosterone acetate-salt

Jo, F; Jo, H; Hilzendeger, AM; Thompson, AP; Cassell, MD; Rutkowski, DT; Davisson, RL; Grobe, JL; Sigmund, CD

Aldosterone mediates angiotensin II-induced interstitial cardiac fibrosis via a Nox2-containing NADPH oxidase

Johar, S; Cave, AC; Narayanapanicker, A; Grieve, DJ; Shah, AM

Angiotensin II increases lipogenesis in 3T3-L1 and human adipose cells

Jones, BH; Standridge, MK; Moustaid, N

Interleukin-6-signal transducer and activator of transcription-3 signaling mediates aortic dissections induced by angiotensin II via the T-helper lymphocyte 17-interleukin 17 axis in C57BL/6 mice

Ju, X; Ijaz, T; Sun, H; Ray, S; Lejeune, W; Lee, C; Recinos, A; Guo, DC; Milewicz, DM; Tilton, RG; Brasier, AR

Human T and natural killer cells possess a functional renin-angiotensin system: further mechanisms of angiotensin II-induced inflammation

Jurewicz, M; McDermott, DH; Sechler, JM; Tinckam, K; Takakura, A; Carpenter, CB; Milford, E; Abdi, R

The SIR2/3/4 complex and SIR2 alone promote longevity in Saccharomyces cerevisiae by two different mechanisms

Kaeberlein, M; McVey, M; Guarente, L

Overproduction of angiotensinogen from adipose tissue induces adipose inflammation, glucose intolerance, and insulin resistance

Kalupahana, NS; Massiera, F; Quignard-Boulange, A; Ailhaud, G; Voy, BH; Wasserman, DH; Moustaid-Moussa, N

Renal transporter activation during angiotensin II hypertension is blunted in IFN-γ(−/−) and IL-17A (−/−) mice

Kamat, NV; Thabet, SR; Xiao, L; Saleh, MA; Kirabo, A; Madhur, MS; Delpire, E; Harrison, DG; McDonough, AA

Molecular cloning of a novel angiotensin II receptor isoform involved in phosphotyrosine phosphatase inhibition

Kambayashi, Y; Bardhan, S; Takahashi, K; Tsuzuki, S; Inui, H; Hamakubo, T; Inagami, T

Critical roles of macrophages in the formation of intracranial aneurysm

Kanematsu, Y; Kanematsu, M; Kurihara, C; Tada, Y; Tsou, TL; van Rooijen, N; Lawton, MT; Young, WL; Liang, EI; Nuki, Y; Hashimoto, T

Slowly progressive, angiotensin II-independent glomerulosclerosis in human (pro)renin receptor-transgenic rats

Kaneshiro, Y; Ichihara, A; Sakoda, M; Takemitsu, T; Nabi, AH; Uddin, MN; Nakagawa, T; Nishiyama, A; Suzuki, F; Inagami, T; Itoh, H

Effects of telmisartan on lipid metabolisms and proinflammatory factors secretion of differentiated 3T3-L1 adipocytes

Kang, C; Yijun, L; Jingtao, D; Changyu, P; Wenhua, Y; Baoan, W; Fangling, M; Xianling, W; Guoqing, Y; Yiming, M; Juming, L

Genetic lineage tracing defines myofibroblast origin and function in the injured heart

Kanisicak, O; Khalil, H; Ivey, MJ; Karch, J; Maliken, BD; Correll, RN; Brody, MJ; J Lin, SC; Aronow, BJ; Tallquist, MD; Molkentin, JD

Heart failure and angiotensin II modulate atrial Pitx2c promotor methylation

Kao, YH; Chen, YC; Chung, CC; Lien, GS; Chen, SA; Kuo, CC; Chen, YJ

Regulation of lifespan in Drosophila by modulation of genes in the TOR signaling pathway

Kapahi, P; Zid, BM; Harper, T; Koslover, D; Sapin, V; Benzer, S

Gut Microbiota Promote Angiotensin II-Induced Arterial Hypertension and Vascular Dysfunction

Karbach, SH; Schönfelder, T; Brandão, I; Wilms, E; Hörmann, N; Jäckel, S; Schüler, R; Finger, S; Knorr, M; Lagrange, J; Brandt, M; Waisman, A; Kossmann, S; Schäfer, K; Münzel, T; Reinhardt, C; Wenzel, P

Mitochondria-targeted esculetin alleviates mitochondrial dysfunction by AMPK-mediated nitric oxide and SIRT3 regulation in endothelial cells: potential implications in atherosclerosis

Karnewar, S; Vasamsetti, SB; Gopoju, R; Kanugula, AK; Ganji, SK; Prabhakar, S; Rangaraj, N; Tupperwar, N; Kumar, JM; Kotamraju, S

Significance of angiotensin 1-7 coupling with MAS1 receptor and other GPCRs to the renin-angiotensin system: IUPHAR Review 22

Karnik, SS; Singh, KD; Tirupula, K; Unal, H

International Union of Basic and Clinical Pharmacology. XCIX. Angiotensin Receptors: Interpreters of Pathophysiological Angiotensinergic Stimuli

Karnik, SS; Unal, H; Kemp, JR; Tirupula, KC; Eguchi, S; Vanderheyden, PM; Thomas, WG

AT2 receptors targeting cardiac protection post-myocardial infarction

Kaschina, E; Lauer, D; Schmerler, P; Unger, T; Steckelings, UM

Essential Role of Smooth Muscle STIM1 in Hypertension and Cardiovascular Dysfunction

Kassan, M; Ait-Aissa, K; Radwan, E; Mali, V; Haddox, S; Gabani, M; Zhang, W; Belmadani, S; Irani, K; Trebak, M; Matrougui, K

Endoplasmic reticulum stress is involved in cardiac damage and vascular endothelial dysfunction in hypertensive mice

Kassan, M; Galán, M; Partyka, M; Saifudeen, Z; Henrion, D; Trebak, M; Matrougui, K

Loss of angiotensin-converting enzyme 2 accelerates maladaptive left ventricular remodeling in response to myocardial infarction

Kassiri, Z; Zhong, J; Guo, D; Basu, R; Wang, X; Liu, PP; Scholey, JW; Penninger, JM; Oudit, GY

Targeted Ablation of Periostin-Expressing Activated Fibroblasts Prevents Adverse Cardiac Remodeling in Mice

Kaur, H; Takefuji, M; Ngai, CY; Carvalho, J; Bayer, J; Wietelmann, A; Poetsch, A; Hoelper, S; Conway, SJ; Möllmann, H; Looso, M; Troidl, C; Offermanns, S; Wettschureck, N

Autophagy at the crossroads of catabolism and anabolism

Kaur, J; Debnath, J

Intratracheal administration of a nanoparticle-based therapy with the angiotensin II type 2 receptor gene attenuates lung cancer growth

Kawabata, A; Baoum, A; Ohta, N; Jacquez, S; Seo, GM; Berkland, C; Tamura, M

AT1 receptor signaling pathways in the cardiovascular system

Kawai, T; Forrester, SJ; O’Brien, S; Baggett, A; Rizzo, V; Eguchi, S

Vascular ADAM17 (a Disintegrin and Metalloproteinase Domain 17) Is Required for Angiotensin II/β-Aminopropionitrile-Induced Abdominal Aortic Aneurysm

Kawai, T; Takayanagi, T; Forrester, SJ; Preston, KJ; Obama, T; Tsuji, T; Kobayashi, T; Boyer, MJ; Cooper, HA; Kwok, HF; Hashimoto, T; Scalia, R; Rizzo, V; Eguchi, S

Angiotensin II enhances integrin and alpha-actinin expression in adult rat cardiac fibroblasts

Kawano, H; Cody, RJ; Graf, K; Goetze, S; Kawano, Y; Schnee, J; Law, RE; Hsueh, WA

Blockade of NF-kappaB ameliorates myocardial hypertrophy in response to chronic infusion of angiotensin II

Kawano, S; Kubota, T; Monden, Y; Kawamura, N; Tsutsui, H; Takesh*ta, A; Sunagawa, K

Angiotensin II- and salt-induced kidney injury through Rac1-mediated mineralocorticoid receptor activation

Kawarazaki, W; Nagase, M; Yoshida, S; Takeuchi, M; Ishizawa, K; Ayuzawa, N; Ueda, K; Fujita, T

The Ca(2+)-activated cation channel TRPM4 is a negative regulator of angiotensin II-induced cardiac hypertrophy

Kecskés, M; Jacobs, G; Kerselaers, S; Syam, N; Menigoz, A; Vangheluwe, P; Freichel, M; Flockerzi, V; Voets, T; Vennekens, R

Activation of histone deacetylase 2 by inducible heat shock protein 70 in cardiac hypertrophy

Kee, HJ; Eom, GH; Joung, H; Shin, S; Kim, JR; Cho, YK; Choe, N; Sim, BW; Jo, D; Jeong, MH; Kim, KK; Seo, JS; Kook, H

Inhibition of histone deacetylation blocks cardiac hypertrophy induced by angiotensin II infusion and aortic banding

Kee, HJ; Sohn, IS; Nam, KI; Park, JE; Qian, YR; Yin, Z; Ahn, Y; Jeong, MH; Bang, YJ; Kim, N; Kim, JK; Kim, KK; Epstein, JA; Kook, H

Extracellular signal-regulated kinases 1 and 2 regulate the balance between eccentric and concentric cardiac growth

Kehat, I; Davis, J; Tiburcy, M; Accornero, F; Saba-El-Leil, MK; Maillet, M; York, AJ; Lorenz, JN; Zimmermann, WH; Meloche, S; Molkentin, JD

AT2 receptor activation induces natriuresis and lowers blood pressure

Kemp, BA; Howell, NL; Gildea, JJ; Keller, SR; Padia, SH; Carey, RM

AT2 Receptor Activation Prevents Sodium Retention and Reduces Blood Pressure in Angiotensin II-Dependent Hypertension

Kemp, BA; Howell, NL; Keller, SR; Gildea, JJ; Padia, SH; Carey, RM

Angiotensin II-regulated microRNA 483-3p directly targets multiple components of the renin-angiotensin system

Kemp, JR; Unal, H; Desnoyer, R; Yue, H; Bhatnagar, A; Karnik, SS

Arrestin-dependent angiotensin AT1 receptor signaling regulates Akt and mTor-mediated protein synthesis

Kendall, RT; Lee, MH; Pleasant, DL; Robinson, K; Kuppuswamy, D; McDermott, PJ; Luttrell, LM

The beta-arrestin pathway-selective type 1A angiotensin receptor (AT1A) agonist [Sar1,Ile4,Ile8]angiotensin II regulates a robust G protein-independent signaling network

Kendall, RT; Strungs, EG; Rachidi, SM; Lee, MH; El-Shewy, HM; Luttrell, DK; Janech, MG; Luttrell, LM

Adaptive Response of T and B Cells in Atherosclerosis

Ketelhuth, DF; Hansson, GK

PPARγ regulates resistance vessel tone through a mechanism involving RGS5-mediated control of protein kinase C and BKCa channel activity

Ketsawatsomkron, P; Lorca, RA; Keen, HL; Weatherford, ET; Liu, X; Pelham, CJ; Grobe, JL; Faraci, FM; England, SK; Sigmund, CD

Cytosolic phospholipase A2α is critical for angiotensin II-induced hypertension and associated cardiovascular pathophysiology

Khan, NS; Song, CY; Jennings, BL; Estes, AM; Fang, XR; Bonventre, JV; Malik, KU

Fibulin-2 is essential for angiotensin II-induced myocardial fibrosis mediated by transforming growth factor (TGF)-β

Khan, SA; Dong, H; Joyce, J; Sasaki, T; Chu, ML; Tsuda, T

Angiotensin-converting enzyme enhances the oxidative response and bactericidal activity of neutrophils

Khan, Z; Shen, XZ; Bernstein, EA; Giani, JF; Eriguchi, M; Zhao, TV; Gonzalez-Villalobos, RA; Fuchs, S; Liu, GY; Bernstein, KE

The β3 subunit contributes to vascular calcium channel upregulation and hypertension in angiotensin II-infused C57BL/6 mice

Kharade, SV; Sonkusare, SK; Srivastava, AK; Thakali, KM; Fletcher, TW; Rhee, SW; Rusch, NJ

NADPH oxidase deficiency exacerbates angiotensin II-induced abdominal aortic aneurysms in mice

Kigawa, Y; Miyazaki, T; Lei, XF; Nakamachi, T; Oguchi, T; Kim-Kaneyama, JR; Taniyama, M; Tsunawaki, S; Shioda, S; Miyazaki, A

Prevention of abdominal aortic aneurysm by anti-microRNA-712 or anti-microRNA-205 in angiotensin II-infused mice

Kim, CW; Kumar, S; Son, DJ; Jang, IH; Griendling, KK; Jo, H

Histone deacetylase and GATA-binding factor 6 regulate arterial remodeling in angiotensin II-induced hypertension

Kim, GR; Cho, SN; Kim, HS; Yu, SY; Choi, SY; Ryu, Y; Lin, MQ; Jin, L; Kee, HJ; Jeong, MH

Activation of mTOR/p70S6 kinase by ANG II inhibits insulin-stimulated endothelial nitric oxide synthase and vasodilation

Kim, JA; Jang, HJ; Martinez-Lemus, LA; Sowers, JR

Molecular and cellular mechanisms of angiotensin II-mediated cardiovascular and renal diseases

Kim, S; Iwao, H

Angiotensin II Regulation of Proliferation, Differentiation, and Engraftment of Hematopoietic Stem Cells

Kim, S; Zingler, M; Harrison, JK; Scott, EW; Cogle, CR; Luo, D; Raizada, MK

Role of NAD(P)H oxidase- and mitochondria-derived reactive oxygen species in cardioprotection of ischemic reperfusion injury by angiotensin II

Kimura, S; Zhang, GX; Nishiyama, A; Shokoji, T; Yao, L; Fan, YY; Rahman, M; Suzuki, T; Maeta, H; Abe, Y

Interferon-gamma and the interferon-inducible chemokine CXCL10 protect against aneurysm formation and rupture

King, VL; Lin, AY; Kristo, F; Anderson, TJ; Ahluwalia, N; Hardy, GJ; Owens, AP; Howatt, DA; Shen, D; Tager, AM; Luster, AD; Daugherty, A; Gerszten, RE

DC isoketal-modified proteins activate T cells and promote hypertension

Kirabo, A; Fontana, V; de Faria, AP; Loperena, R; Galindo, CL; Wu, J; Bikineyeva, AT; Dikalov, S; Xiao, L; Chen, W; Saleh, MA; Trott, DW; Itani, HA; Vinh, A; Amarnath, V; Amarnath, K; Guzik, TJ; Bernstein, KE; Shen, XZ; Shyr, Y; Chen, SC; Mernaugh, RL; Laffer, CL; Elijovich, F; Davies, SS; Moreno, H; Madhur, MS; Roberts, J; Harrison, DG

Vascular smooth muscle Jak2 mediates angiotensin II-induced hypertension via increased levels of reactive oxygen species

Kirabo, A; Kearns, PN; Jarajapu, YP; Sasser, JM; Oh, SP; Grant, MB; Kasahara, H; Cardounel, AJ; Baylis, C; Wagner, K-U; Sayeski, PP

Interleukin-10 inhibits chronic angiotensin II-induced pathological autophagy

Kishore, R; Krishnamurthy, P; Garikipati, VN; Benedict, C; Nickoloff, E; Khan, M; Johnson, J; Gumpert, AM; Koch, WJ; Verma, SK

Urea transporter UT-A1 and aquaporin-2 proteins decrease in response to angiotensin II or norepinephrine-induced acute hypertension

Klein, JD; Murrell, BP; Tucker, S; Kim, YH; Sands, JM

The intrarenal renin-angiotensin system: from physiology to the pathobiology of hypertension and kidney disease

Kobori, H; Nangaku, M; Navar, LG; Nishiyama, A

Essential role of angiotensin II type 1a receptors in the host vascular wall, but not the bone marrow, in the pathogenesis of angiotensin II-induced atherosclerosis

Koga, J; Egashira, K; Matoba, T; Kubo, M; Ihara, Y; Iwai, M; Horiuchi, M; Sunagawa, K

Angiotensin-converting enzyme (ACE) inhibitors modulate cellular retinol-binding protein 1 and adiponectin expression in adipocytes via the ACE-dependent signaling cascade

Kohlstedt, K; Gershome, C; Trouvain, C; Hofmann, WK; Fichtlscherer, S; Fleming, I

Adipocyte-derived lipids increase angiotensin-converting enzyme (ACE) expression and modulate macrophage phenotype

Kohlstedt, K; Trouvain, C; Namgaladze, D; Fleming, I

Cardiac-specific deletion of acetyl CoA carboxylase 2 prevents metabolic remodeling during pressure-overload hypertrophy

Kolwicz, SC; Olson, DP; Marney, LC; Garcia-Menendez, L; Synovec, RE; Tian, R

Neurovascular protection by telmisartan via reducing neuroinflammation in stroke-resistant spontaneously hypertensive rat brain after ischemic stroke

Kono, S; Kurata, T; Sato, K; Omote, Y; Hishikawa, N; Yamash*ta, T; Deguchi, K; Abe, K

Determination of an angiotensin II-regulated proteome in primary human kidney cells by stable isotope labeling of amino acids in cell culture (SILAC)

Konvalinka, A; Zhou, J; Dimitromanolakis, A; Drabovich, AP; Fang, F; Gurley, S; Coffman, T; John, R; Zhang, SL; Diamandis, EP; Scholey, JW

Endothelial metabolism of angiotensin II to angiotensin III, not angiotensin (1-7), augments the vasorelaxation response in adrenal cortical arteries

Kopf, PG; Campbell, WB

Inflammatory monocytes determine endothelial nitric-oxide synthase uncoupling and nitro-oxidative stress induced by angiotensin II

Kossmann, S; Hu, H; Steven, S; Schönfelder, T; Fraccarollo, D; Mikhed, Y; Brähler, M; Knorr, M; Brandt, M; Karbach, SH; Becker, C; Oelze, M; Bauersachs, J; Widder, J; Münzel, T; Daiber, A; Wenzel, P

Angiotensin II-induced vascular dysfunction depends on interferon-γ-driven immune cell recruitment and mutual activation of monocytes and NK-cells

Kossmann, S; Schwenk, M; Hausding, M; Karbach, SH; Schmidgen, MI; Brandt, M; Knorr, M; Hu, H; Kröller-Schön, S; Schönfelder, T; Grabbe, S; Oelze, M; Daiber, A; Münzel, T; Becker, C; Wenzel, P

G-protein-coupled receptor Mas is a physiological antagonist of the angiotensin II type 1 receptor

Kostenis, E; Milligan, G; Christopoulos, A; Sanchez-Ferrer, CF; Heringer-Walther, S; Sexton, PM; Gembardt, F; Kellett, E; Martini, L; Vanderheyden, P; Schultheiss, HP; Walther, T

AT2R agonist, compound 21, is reno-protective against type 1 diabetic nephropathy

Koulis, C; Chow, BS; McKelvey, M; Steckelings, UM; Unger, T; Thallas-Bonke, V; Thomas, MC; Cooper, ME; Jandeleit-Dahm, KA; Allen, TJ

Exosomes: vehicles of intercellular signaling, biomarkers, and vectors of cell therapy

Kourembanas, S

Deficiency of the interleukin 17/23 axis accelerates renal injury in mice with deoxycorticosterone acetate+angiotensin ii-induced hypertension

Krebs, CF; Lange, S; Niemann, G; Rosendahl, A; Lehners, A; Meyer-Schwesinger, C; Stahl, RA; Benndorf, RA; Velden, J; Paust, HJ; Panzer, U; Ehmke, H; Wenzel, UO

Wnt Signaling Pathway Inhibitor Sclerostin Inhibits Angiotensin II-Induced Aortic Aneurysm and Atherosclerosis

Krishna, SM; Seto, SW; Jose, RJ; Li, J; Morton, SK; Biros, E; Wang, Y; Nsengiyumva, V; Lindeman, JH; Loots, GG; Rush, CM; Craig, JM; Golledge, J

Peroxisome proliferator-activated receptor γ, coactivator 1α deletion induces angiotensin II-associated vascular dysfunction by increasing mitochondrial oxidative stress and vascular inflammation

Kröller-Schön, S; Jansen, T; Schüler, A; Oelze, M; Wenzel, P; Hausding, M; Kerahrodi, JG; Beisele, M; Lackner, KJ; Daiber, A; Münzel, T; Schulz, E

PPAR gamma mediates high-fat diet-induced adipocyte hypertrophy and insulin resistance

Kubota, N; Terauchi, Y; Miki, H; Tamemoto, H; Yamauchi, T; Komeda, K; Satoh, S; Nakano, R; Ishii, C; Sugiyama, T; Eto, K; Tsubamoto, Y; Okuno, A; Murakami, K; Sekihara, H; Hasegawa, G; Naito, M; Toyoshima, Y; Tanaka, S; Shiota, K; Kitamura, T; Fujita, T; Ezaki, O; Aizawa, S; Kadowaki, T

Effects of angiotensin II type 1 receptor antagonist on electrical and structural remodeling in atrial fibrillation

Kumagai, K; Nakashima, H; Urata, H; Gondo, N; Arakawa, K; Saku, K

The intracrine renin-angiotensin system

Kumar, R; Thomas, CM; Yong, QC; Chen, W; Baker, KM

Intracardiac intracellular angiotensin system in diabetes

Kumar, R; Yong, QC; Thomas, CM; Baker, KM

Angiotensin II induces premature senescence of vascular smooth muscle cells and accelerates the development of atherosclerosis via a p21-dependent pathway

Kunieda, T; Minamino, T; Nishi, J; Tateno, K; Oyama, T; Katsuno, T; Miyauchi, H; Orimo, M; Okada, S; Takamura, M; Nagai, T; Kaneko, S; Komuro, I

New take on the role of angiotensin II in cardiac hypertrophy and fibrosis

Kurdi, M; Booz, GW

Three 4-letter words of hypertension-related cardiac hypertrophy: TRPC, mTOR, and HDAC

Kurdi, M; Booz, GW

Neutrophil-derived matrix metalloproteinase 9 triggers acute aortic dissection

Kurihara, T; Shimizu-Hirota, R; Shimoda, M; Adachi, T; Shimizu, H; Weiss, SJ; Itoh, H; Hori, S; Aikawa, N; Okada, Y

Cardiac angiotensin II type 2 receptor activates the kinin/NO system and inhibits fibrosis

Kurisu, S; Ozono, R; Oshima, T; Kambe, M; Ishida, T; Sugino, H; Matsuura, H; Chayama, K; Teranishi, Y; Iba, O; Amano, K; Matsubara, H

Suppression of aging in mice by the hormone Klotho

Kurosu, H; Yamamoto, M; Clark, JD; Pastor, JV; Nandi, A; Gurnani, P; McGuinness, OP; Chikuda, H; Yamaguchi, M; Kawaguchi, H; Shimomura, I; Takayama, Y; Herz, J; Kahn, CR; Rosenblatt, KP; Kuro-o, M

Interleukin-10 deficiency aggravates angiotensin II-induced cardiac remodeling in mice

Kwon, WY; Cha, HN; Heo, JY; Choi, JH; Jang, BI; Lee, IK; Park, SY

Vascular Tissue-Type Plasminogen Activator Promotes Intracranial Aneurysm Formation

Labeyrie, PE; Goulay, R; Martinez de Lizarrondo, S; Hébert, M; Gauberti, M; Maubert, E; Delaunay, B; Gory, B; Signorelli, F; Turjman, F; Touzé, E; Courthéoux, P; Vivien, D; Orset, C

Effect of eprosartan on cytoplasmic free calcium mobilization, platelet activation, and microparticle formation in hypertension

Labiós, M; Martínez, M; Gabriel, F; Guiral, V; Munoz, A; Aznar, J

Protein O-GlcNAcylation: a new signaling paradigm for the cardiovascular system

Laczy, B; Hill, BG; Wang, K; Paterson, AJ; White, CR; Xing, D; Chen, YF; Darley-Usmar, V; Oparil, S; Chatham, JC

p47(phox) is required for afferent arteriolar contractile responses to angiotensin II and perfusion pressure in mice

Lai, EY; Solis, G; Luo, Z; Carlstrom, M; Sandberg, K; Holland, S; Wellstein, A; Welch, WJ; Wilcox, CS

Rap1b in smooth muscle and endothelium is required for maintenance of vascular tone and normal blood pressure

Lakshmikanthan, S; Zieba, BJ; Ge, ZD; Momotani, K; Zheng, X; Lund, H; Artamonov, MV; Maas, JE; Szabo, A; Zhang, DX; Auchampach, JA; Mattson, DL; Somlyo, AV; Chrzanowska-Wodnicka, M

Tumor necrosis factor-alpha convertase (ADAM17) mediates regulated ectodomain shedding of the severe-acute respiratory syndrome-coronavirus (SARS-CoV) receptor, angiotensin-converting enzyme-2 (ACE2)

Lambert, DW; Yarski, M; Warner, FJ; Thornhill, P; Parkin, ET; Smith, AI; Hooper, NM; Turner, AJ

Role of p47(phox) in vascular oxidative stress and hypertension caused by angiotensin II

Landmesser, U; Cai, H; Dikalov, S; McCann, L; Hwang, J; Jo, H; Holland, SM; Harrison, DG

mTOR signaling in growth control and disease

Laplante, M; Sabatini, DM

Biochemistry, physiology, and pathophysiology of NADPH oxidases in the cardiovascular system

Lassègue, B; San Martín, A; Griendling, KK

Salt, aldosterone, and insulin resistance: impact on the cardiovascular system

Lastra, G; Dhuper, S; Johnson, MS; Sowers, JR

Obesity and cardiovascular disease: role of adipose tissue, inflammation, and the renin-angiotensin-aldosterone system

Lastra, G; Sowers, JR

Angiotensin type 2 receptor stimulation ameliorates left ventricular fibrosis and dysfunction via regulation of tissue inhibitor of matrix metalloproteinase 1/matrix metalloproteinase 9 axis and transforming growth factor β1 in the rat heart

Lauer, D; Slavic, S; Sommerfeld, M; Thöne-Reineke, C; Sharkovska, Y; Hallberg, A; Dahlöf, B; Kintscher, U; Unger, T; Steckelings, UM; Kaschina, E

Nox NADPH oxidases and the endoplasmic reticulum

Laurindo, FR; Araujo, TL; Abrahão, TB

Discovery and characterization of alamandine: a novel component of the renin-angiotensin system

Lautner, RQ; Villela, DC; Fraga-Silva, RA; Silva, N; Verano-Braga, T; Costa-Fraga, F; Jankowski, J; Jankowski, V; Sousa, F; Alzamora, A; Soares, E; Barbosa, C; Kjeldsen, F; Oliveira, A; Braga, J; Savergnini, S; Maia, G; Peluso, AB; Passos-Silva, D; Ferreira, A; Alves, F; Martins, A; Raizada, M; Paula, R; Motta-Santos, D; Klempin, F; Pimenta, A; Alenina, N; Sinisterra, R; Bader, M; Campagnole-Santos, MJ; Santos, RA

Autophagy in cardiovascular biology

Lavandero, S; Chiong, M; Rothermel, BA; Hill, JA

Adjacent expression of renin and angiotensinogen in the rostral ventrolateral medulla using a dual-reporter transgenic model

Lavoie, JL; Cassell, MD; Gross, KW; Sigmund, CD

Localization of renin expressing cells in the brain, by use of a REN-eGFP transgenic model

Lavoie, JL; Cassell, MD; Gross, KW; Sigmund, CD

Evidence supporting a functional role for intracellular renin in the brain

Lavoie, JL; Liu, X; Bianco, RA; Beltz, TG; Johnson, AK; Sigmund, CD

Minireview: overview of the renin-angiotensin system–an endocrine and paracrine system

Lavoie, JL; Sigmund, CD

Angiotensin II contributes to renal fibrosis independently of Notch pathway activation

Lavoz, C; Rodrigues-Diez, R; Benito-Martin, A; Rayego-Mateos, S; Rodrigues-Diez, RR; Alique, M; Ortiz, A; Mezzano, S; Egido, J; Ruiz-Ortega, M

Getting to the heart of the matter: new insights into cardiac fibrosis

Leask, A

A polyaromatic caveolin-binding-like motif in the cytoplasmic tail of the type 1 receptor for angiotensin II plays an important role in receptor trafficking and signaling

Leclerc, PC; Auger-Messier, M; Lanctot, PM; Escher, E; Leduc, R; Guillemette, G

S-nitrosylation of cysteine 289 of the AT1 receptor decreases its binding affinity for angiotensin II

Leclerc, PC; Lanctot, PM; Auger-Messier, M; Escher, E; Leduc, R; Guillemette, G

Nox4 NADPH oxidase mediates peroxynitrite-dependent uncoupling of endothelial nitric-oxide synthase and fibronectin expression in response to angiotensin II: role of mitochondrial reactive oxygen species

Lee, DY; Wauquier, F; Eid, AA; Roman, LJ; Ghosh-Choudhury, G; Khazim, K; Block, K; Gorin, Y

Deficiency of endothelium-specific transcription factor Sox17 induces intracranial aneurysm

Lee, S; Kim, IK; Ahn, JS; Woo, DC; Kim, ST; Song, S; Koh, GY; Kim, HS; Jeon, BH; Kim, I

Increased AQP2 targeting in primary cultured IMCD cells in response to angiotensin II through AT1 receptor

Lee, YJ; Song, IK; Jang, KJ; Nielsen, J; Frøkiaer, J; Nielsen, S; Kwon, TH

Distinct renin isoforms generated by tissue-specific transcription initiation and alternative splicing

Lee-Kirsch, MA; Gaudet, F; Cardoso, MC; Lindpaintner, K

Identification of Hic-5 as a novel scaffold for the MKK4/p54 JNK pathway in the development of abdominal aortic aneurysms

Lei, XF; Kim-Kaneyama, JR; Arita-Okubo, S; Offermanns, S; Itabe, H; Miyazaki, T; Miyazaki, A

Targeting the calpain/calpastatin system as a new strategy to prevent cardiovascular remodeling in angiotensin II-induced hypertension

Letavernier, E; Perez, J; Bellocq, A; Mesnard, L; de Castro Keller, A; Haymann, JP; Baud, L

Noncoding RNAs in vascular disease

Leung, A; Natarajan, R

Novel long noncoding RNAs are regulated by angiotensin II in vascular smooth muscle cells

Leung, A; Trac, C; Jin, W; Lanting, L; Akbany, A; Sætrom, P; Schones, DE; Natarajan, R

Molecular mechanisms of angiotensin II stimulation on aquaporin-2 expression and trafficking

Li, C; Wang, W; Rivard, CJ; Lanaspa, MA; Summer, S; Schrier, RW

Partial inhibition of activin receptor-like kinase 4 attenuates pressure overload-induced cardiac fibrosis and improves cardiac function

Li, CY; Chen, YH; Wang, Q; Hou, JW; Wang, H; Wang, YP; Li, YG

Dual-specificity phosphatase 14 protects the heart from aortic banding-induced cardiac hypertrophy and dysfunction through inactivation of TAK1-P38MAPK/-JNK1/2 signaling pathway

Li, CY; Zhou, Q; Yang, LC; Chen, YH; Hou, JW; Guo, K; Wang, YP; Li, YG

α7 Nicotinic Acetylcholine Receptor Relieves Angiotensin II-Induced Senescence in Vascular Smooth Muscle Cells by Raising Nicotinamide Adenine Dinucleotide-Dependent SIRT1 Activity

Li, DJ; Huang, F; Ni, M; Fu, H; Zhang, LS; Shen, FM

Regulator of G protein signaling 5 protects against cardiac hypertrophy and fibrosis during biomechanical stress of pressure overload

Li, H; He, C; Feng, J; Zhang, Y; Tang, Q; Bian, Z; Bai, X; Zhou, H; Jiang, H; Heximer, SP; Qin, M; Huang, H; Liu, PP; Huang, C

Calmodulin kinase II is required for angiotensin II-mediated vascular smooth muscle hypertrophy

Li, H; Li, W; Gupta, AK; Mohler, PJ; Anderson, ME; Grumbach, IM

Renal proximal tubule angiotensin AT1A receptors regulate blood pressure

Li, H; Weatherford, ET; Davis, DR; Keen, HL; Grobe, JL; Daugherty, A; Cassis, LA; Allen, AM; Sigmund, CD

Activation of NADPH oxidase during progression of cardiac hypertrophy to failure

Li, JM; Gall, NP; Grieve, DJ; Chen, M; Shah, AM

Angiotensin II increases periostin expression via Ras/p38 MAPK/CREB and ERK1/2/TGF-β1 pathways in cardiac fibroblasts

Li, L; Fan, D; Wang, C; Wang, JY; Cui, XB; Wu, D; Zhou, Y; Wu, LL

Remodeling of Afferent Arterioles From Mice With Oxidative Stress Does Not Account for Increased Contractility but Does Limit Excessive Wall Stress

Li, L; Feng, D; Luo, Z; Welch, WJ; Wilcox, CS; Lai, EY

Losartan Inhibits Vascular Calcification by Suppressing the BMP2 and Runx2 Expression in Rats In Vivo

Li, M; Wu, P; Shao, J; Ke, Z; Li, D; Wu, J

Activation of the cardiac proteasome promotes angiotension II-induced hypertrophy by down-regulation of ATRAP

Li, N; Wang, HX; Han, QY; Li, WJ; Zhang, YL; Du, J; Xia, YL; Li, HH

NFATc4 is negatively regulated in miR-133a-mediated cardiomyocyte hypertrophic repression

Li, Q; Lin, X; Yang, X; Chang, J

TIEG1 Inhibits Angiotensin II-induced Cardiomyocyte Hypertrophy by Inhibiting Transcription Factor GATA4

Li, Q; Shen, P; Zeng, S; Liu, P

Overexpression of microRNA-99a Attenuates Cardiac Hypertrophy

Li, Q; Xie, J; Wang, B; Li, R; Bai, J; Ding, L; Gu, R; Wang, L; Xu, B

Tgfbr2 disruption in postnatal smooth muscle impairs aortic wall homeostasis

Li, W; Li, Q; Jiao, Y; Qin, L; Ali, R; Zhou, J; Ferruzzi, J; Kim, RW; Geirsson, A; Dietz, HC; Offermanns, S; Humphrey, JD; Tellides, G

Angiotensin II regulates brain (pro)renin receptor expression through activation of cAMP response element-binding protein

Li, W; Liu, J; Hammond, SL; Tjalkens, RB; Saifudeen, Z; Feng, Y

Role of caveolin 1 in AT1a receptor-mediated uptake of angiotensin II in the proximal tubule of the kidney

Li, XC; Gu, V; Miguel-Qin, E; Zhuo, JL

AT1a receptor knockout in mice impairs urine concentration by reducing basal vasopressin levels and its receptor signaling proteins in the inner medulla

Li, XC; Shao, Y; Zhuo, JL

Role of the Na+/H+ exchanger 3 in angiotensin II-induced hypertension in NHE3-deficient mice with transgenic rescue of NHE3 in small intestines

Li, XC; Shull, GE; Miguel-Qin, E; Chen, F; Zhuo, JL

Role of the Na+/H+ exchanger 3 in angiotensin II-induced hypertension

Li, XC; Shull, GE; Miguel-Qin, E; Zhuo, JL

Phosphoproteomic analysis of AT1 receptor-mediated signaling responses in proximal tubules of angiotensin II-induced hypertensive rats

Li, XC; Zhuo, JL

Adiponectin Upregulates MiR-133a in Cardiac Hypertrophy through AMPK Activation and Reduced ERK1/2 Phosphorylation

Li, Y; Cai, X; Guan, Y; Wang, L; Wang, S; Li, Y; Fu, Y; Gao, X; Su, G

Cellular Repressor of E1A-Stimulated Genes Is a Critical Determinant of Vascular Remodeling in Response to Angiotensin II

Li, Y; Liu, Y; Tian, X; Zhang, Y; Song, H; Liu, M; Zhang, X; Liu, H; Zhang, J; Zhang, Q; Liu, D; Peng, C; Yan, C; Han, Y

γδT Cell-derived interleukin-17A via an interleukin-1β-dependent mechanism mediates cardiac injury and fibrosis in hypertension

Li, Y; Wu, Y; Zhang, C; Li, P; Cui, W; Hao, J; Ma, X; Yin, Z; Du, J

Interleukin-12p35 deletion promotes CD4 T-cell-dependent macrophage differentiation and enhances angiotensin II-Induced cardiac fibrosis

Li, Y; Zhang, C; Wu, Y; Han, Y; Cui, W; Jia, L; Cai, L; Cheng, J; Li, H; Du, J

Surgery-Induced Hippocampal Angiotensin II Elevation Causes Blood-Brain Barrier Disruption via MMP/TIMP in Aged Rats

Li, Z; Mo, N; Li, L; Cao, Y; Wang, W; Liang, Y; Deng, H; Xing, R; Yang, L; Ni, C; Chui, D; Guo, X

Aberrant endoplasmic reticulum stress in vascular smooth muscle increases vascular contractility and blood pressure in mice deficient of AMP-activated protein kinase-α2 in vivo

Liang, B; Wang, S; Wang, Q; Zhang, W; Viollet, B; Zhu, Y; Zou, MH

Suppression of experimental abdominal aortic aneurysms in the rat by treatment with angiotensin-converting enzyme inhibitors

Liao, S; Miralles, M; Kelley, BJ; Curci, JA; Borhani, M; Thompson, RW

Role of inflammation in the development of renal damage and dysfunction in angiotensin II-induced hypertension

Liao, TD; Yang, XP; Liu, YH; Shesely, EG; Cavasin, MA; Kuziel, WA; Pagano, PJ; Carretero, OA

Regulation of mitochondrial morphology by positive feedback interaction between PKCδ and Drp1 in vascular smooth muscle cell

Lim, S; Lee, SY; Seo, HH; Ham, O; Lee, C; Park, JH; Lee, J; Seung, M; Yun, I; Han, SM; Lee, S; Choi, E; Hwang, KC

Prevention of aortic fibrosis by N-acetyl-seryl-aspartyl-lysyl-proline in angiotensin II-induced hypertension

Lin, CX; Rhaleb, NE; Yang, XP; Liao, TD; D’Ambrosio, MA; Carretero, OA

Mas receptor mediates cardioprotection of angiotensin-(1-7) against Angiotensin II-induced cardiomyocyte autophagy and cardiac remodelling through inhibition of oxidative stress

Lin, L; Liu, X; Xu, J; Weng, L; Ren, J; Ge, J; Zou, Y

IP3 receptors regulate vascular smooth muscle contractility and hypertension

Lin, Q; Zhao, G; Fang, X; Peng, X; Tang, H; Wang, H; Jing, R; Liu, J; Lederer, WJ; Chen, J; Ouyang, K

Methyl-beta-cyclodextrin prevents angiotensin II-induced tachyphylactic contractile responses in rat aorta

Linder, AE; Thakali, KM; Thompson, JM; Watts, SW; Webb, RC; Leite, R

Suppression of Resting Metabolism by the Angiotensin AT2 Receptor

Littlejohn, NK; Keen, HL; Weidemann, BJ; Claflin, KE; Tobin, KV; Markan, KR; Park, S; Naber, MC; Gourronc, FA; Pearson, NA; Liu, X; Morgan, DA; Klingelhutz, AJ; Potthoff, MJ; Rahmouni, K; Sigmund, CD; Grobe, JL

Elevated Transglutaminase Activity Triggers Angiotensin Receptor Activating Autoantibody Production and Pathophysiology of Preeclampsia

Liu, C; Luo, R; Elliott, SE; Wang, W; Parchim, NF; Iriyama, T; Daugherty, PS; Blackwell, SC; Sibai, BM; Kellems, RE; Xia, Y

Tissue transglutaminase contributes to the pathogenesis of preeclampsia and stabilizes placental angiotensin receptor type 1 by ubiquitination-preventing isopeptide modification

Liu, C; Wang, W; Parchim, N; Irani, RA; Blackwell, SC; Sibai, B; Jin, J; Kellems, RE; Xia, Y

Angiotensin II and Abdominal Aortic Aneurysms: An Update

Liu, J; Daugherty, A; Lu, H

Angiotensin type 1a receptor deficiency decreases amyloid β-protein generation and ameliorates brain amyloid pathology

Liu, J; Liu, S; Matsumoto, Y; Murakami, S; Sugakawa, Y; Kami, A; Tanabe, C; Maeda, T; Michikawa, M; Komano, H; Zou, K

Adrenomedullin inhibits angiotensin II-induced oxidative stress via Csk-mediated inhibition of Src activity

Liu, J; Shimosawa, T; Matsui, H; Meng, F; Supowit, SC; DiPette, DJ; Ando, K; Fujita, T

ARHGAP18 Protects Against Thoracic Aortic Aneurysm Formation by Mitigating the Synthetic and Proinflammatory Smooth Muscle Cell Phenotype

Liu, R; Lo, L; Lay, AJ; Zhao, Y; Ting, KK; Robertson, EN; Sherrah, AG; Jarrah, S; Li, H; Zhou, Z; Hambly, BD; Richmond, DR; Jeremy, RW; Bannon, PG; Vadas, MA; Gamble, JR

Pak1 as a novel therapeutic target for antihypertrophic treatment in the heart

Liu, W; Zi, M; Naumann, R; Ulm, S; Jin, J; Taglieri, DM; Prehar, S; Gui, J; Tsui, H; Xiao, R-P; Neyses, L; Solaro, RJ; Ke, Y; Cartwright, EJ; Lei, M; Wang, X

Regulator of G protein signaling 3 protects against cardiac hypertrophy in mice

Liu, Y; Huang, H; Zhang, Y; Zhu, XY; Zhang, R; Guan, LH; Tang, Q; Jiang, H; Huang, C

Calorie restriction protects against experimental abdominal aortic aneurysms in mice

Liu, Y; Wang, TT; Zhang, R; Fu, WY; Wang, X; Wang, F; Gao, P; Ding, YN; Xie, Y; Hao, DL; Chen, HZ; Liu, DP

MicroRNA-26a protects against cardiac hypertrophy via inhibiting GATA4 in rat model and cultured cardiomyocytes

Liu, Y; Wang, Z; Xiao, W

Role of the NADPH oxidases in the subfornical organ in angiotensin II-induced hypertension

Lob, HE; Schultz, D; Marvar, PJ; Davisson, RL; Harrison, DG

Role of vascular extracellular superoxide dismutase in hypertension

Lob, HE; Vinh, A; Li, L; Blinder, Y; Offermanns, S; Harrison, DG

Moderate caveolin-1 downregulation prevents NADPH oxidase-dependent endothelial nitric oxide synthase uncoupling by angiotensin II in endothelial cells

Lobysheva, I; Rath, G; Sekkali, B; Bouzin, C; Feron, O; Gallez, B; Dessy, C; Balligand, JL

Angiotensin II impairs endothelial function via tyrosine phosphorylation of the endothelial nitric oxide synthase

Loot, AE; Schreiber, JG; Fisslthaler, B; Fleming, I

The angiotensin II type I receptor-associated protein, ATRAP, is a transmembrane protein and a modulator of angiotensin II signaling

Lopez-Ilasaca, M; Liu, X; Tamura, K; Dzau, VJ

Osteopontin is indispensible for AP1-mediated angiotensin II-related miR-21 transcription during cardiac fibrosis

Lorenzen, JM; Schauerte, C; Hübner, A; Kölling, M; Martino, F; Scherf, K; Batkai, S; Zimmer, K; Foinquinos, A; Kaucsar, T; Fiedler, J; Kumarswamy, R; Bang, C; Hartmann, D; Gupta, SK; Kielstein, J; Jungmann, A; Katus, HA; Weidemann, F; Müller, OJ; Haller, H; Thum, T

Atherosclerosis

Lu, H; Daugherty, A

Involvement of the renin-angiotensin system in abdominal and thoracic aortic aneurysms

Lu, H; Rateri, DL; Bruemmer, D; Cassis, LA; Daugherty, A

Regulation of coronary arterial BK channels by caveolae-mediated angiotensin II signaling in diabetes mellitus

Lu, T; Zhang, DM; Wang, XL; He, T; Wang, RX; Chai, Q; Katusic, ZS; Lee, HC

Elevated Endothelial Hypoxia-Inducible Factor-1α Contributes to Glomerular Injury and Promotes Hypertensive Chronic Kidney Disease

Luo, R; Zhang, W; Zhao, C; Zhang, Y; Wu, H; Jin, J; Zhang, W; Grenz, A; Eltzschig, HK; Tao, L; Kellems, RE; Xia, Y

SIRT4 accelerates Ang II-induced pathological cardiac hypertrophy by inhibiting manganese superoxide dismutase activity

Luo, YX; Tang, X; An, XZ; Xie, XM; Chen, XF; Zhao, X; Hao, DL; Chen, HZ; Liu, DP

The renin-angiotensin-aldosterone system and glucose homeostasis

Luther, JM; Brown, NJ

Phosphorylation of smooth muscle 22α facilitates angiotensin II-induced ROS production via activation of the PKCδ-P47phox axis through release of PKCδ and actin dynamics and is associated with hypertrophy and hyperplasia of vascular smooth muscle cells in vitro and in vivo

Lv, P; Miao, SB; Shu, YN; Dong, LH; Liu, G; Xie, XL; Gao, M; Wang, YC; Yin, YJ; Wang, XJ; Han, M

Arrestins in the cardiovascular system

Lymperopoulos, A; Bathgate, A

Different potencies of angiotensin receptor blockers at suppressing adrenal β-Arrestin1-dependent post-myocardial infarction hyperaldosteronism

Lymperopoulos, A; Sturchler, E; Bathgate-Siryk, A; Dabul, S; Garcia, D; Walklett, K; Rengo, G; McDonald, P; Koch, WJ

A critical role of cardiac fibroblast-derived exosomes in activating renin angiotensin system in cardiomyocytes

Lyu, L; Wang, H; Li, B; Qin, Q; Qi, L; Nagarkatti, M; Nagarkatti, P; Janicki, JS; Wang, XL; Cui, T

Neuroprotective effect of angiotensin II type 2 receptor during cerebral ischemia/reperfusion

Ma, CY; Yin, L

Inhibition of KLF5-Myo9b-RhoA Pathway-Mediated Podosome Formation in Macrophages Ameliorates Abdominal Aortic Aneurysm

Ma, D; Zheng, B; Suzuki, T; Zhang, R; Jiang, C; Bai, D; Yin, W; Yang, Z; Zhang, X; Hou, L; Zhan, H; Wen, JK

The requirement of CD8+ T cells to initiate and augment acute cardiac inflammatory response to high blood pressure

Ma, F; Feng, J; Zhang, C; Li, Y; Qi, G; Li, H; Wu, Y; Fu, Y; Zhao, Y; Chen, H; Du, J; Tang, H

Macrophage-stimulated cardiac fibroblast production of IL-6 is essential for TGF β/Smad activation and cardiac fibrosis induced by angiotensin II

Ma, F; Li, Y; Jia, L; Han, Y; Cheng, J; Li, H; Qi, Y; Du, J

Sirtuin3 Dysfunction Is the Key Determinant of Skeletal Muscle Insulin Resistance by Angiotensin II

Macconi, D; Perico, L; Longaretti, L; Morigi, M; Cassis, P; Buelli, S; Perico, N; Remuzzi, G; Benigni, A

Wnt/beta-catenin signaling: components, mechanisms, and diseases

MacDonald, BT; Tamai, K; He, X

Redox signaling in cardiovascular health and disease

Madamanchi, NR; Runge, MS

Role of interleukin 17 in inflammation, atherosclerosis, and vascular function in apolipoprotein e-deficient mice

Madhur, MS; Funt, SA; Li, L; Vinh, A; Chen, W; Lob, HE; Iwakura, Y; Blinder, Y; Rahman, A; Quyyumi, AA; Harrison, DG

Interleukin 17 promotes angiotensin II-induced hypertension and vascular dysfunction

Madhur, MS; Lob, HE; McCann, LA; Iwakura, Y; Blinder, Y; Guzik, TJ; Harrison, DG

MicroRNA-21 blocks abdominal aortic aneurysm development and nicotine-augmented expansion

Maegdefessel, L; Azuma, J; Toh, R; Deng, A; Merk, DR; Raiesdana, A; Leeper, NJ; Raaz, U; Schoelmerich, AM; McConnell, MV; Dalman, RL; Spin, JM; Tsao, PS

Inhibition of microRNA-29b reduces murine abdominal aortic aneurysm development

Maegdefessel, L; Azuma, J; Toh, R; Merk, DR; Deng, A; Chin, JT; Raaz, U; Schoelmerich, AM; Raiesdana, A; Leeper, NJ; McConnell, MV; Dalman, RL; Spin, JM; Tsao, PS

Arterial stiffness and the renin-angiotensin-aldosterone system

Mahmud, A; Feely, J

The role of the adventitia in vascular inflammation

Maiellaro, K; Taylor, WR

Catalase overexpression in aortic smooth muscle prevents pathological mechanical changes underlying abdominal aortic aneurysm formation

Maiellaro-Rafferty, K; Weiss, D; Joseph, G; Wan, W; Gleason, RL; Taylor, WR

Interleukin-2/Anti-Interleukin-2 Immune Complex Expands Regulatory T Cells and Reduces Angiotensin II-Induced Aortic Stiffening

Majeed, B; Tawinwung, S; Eberson, LS; Secomb, TW; Larmonier, N; Larson, DF

Gene expression profiles linked to AT1 angiotensin receptors in the kidney

Makhanova, NA; Crowley, SD; Griffiths, RC; Coffman, TM

Pharmacological stabilization of intracranial aneurysms in mice: a feasibility study

Makino, H; Tada, Y; Wada, K; Liang, EI; Chang, M; Mobashery, S; Kanematsu, Y; Kurihara, C; Palova, E; Kanematsu, M; Kitazato, K; Hashimoto, T

Role of the renin-angiotensin system on abdominal aortic aneurysms

Malekzadeh, S; Fraga-Silva, RA; Trachet, B; Montecucco, F; Mach, F; Stergiopulos, N

AT1 receptor antagonism to reduce aortic expansion in Marfan syndrome: lost in translation or in need of different interpretation?

Mallat, Z; Daugherty, A

The anti-ageing hormone klotho induces Nrf2-mediated antioxidant defences in human aortic smooth muscle cells

Maltese, G; Psefteli, PM; Rizzo, B; Srivastava, S; Gnudi, L; Mann, GE; Siow, RC

Angiotensin II increases activity of the epithelial Na+ channel (ENaC) in distal nephron additively to aldosterone

Mamenko, M; Zaika, O; Ilatovskaya, DV; Staruschenko, A; Pochynyuk, O

Chronic angiotensin II infusion drives extensive aldosterone-independent epithelial Na+ channel activation

Mamenko, M; Zaika, O; Prieto, MC; Jensen, VB; Doris, PA; Navar, LG; Pochynyuk, O

AP-1-dependent transcriptional regulation of NADPH oxidase in human aortic smooth muscle cells: role of p22phox subunit

Manea, A; Manea, SA; Gafencu, AV; Raicu, M; Simionescu, M

The role of IL-6 in the physiologic versus hypertensive blood pressure actions of angiotensin II

Manhiani, MM; Seth, DM; Banes-Berceli, AK; Satou, R; Navar, LG; Brands, MW

Hypertension and atrial fibrillation: diagnostic approach, prevention and treatment. Position paper of the Working Group ‘Hypertension Arrhythmias and Thrombosis’ of the European Society of Hypertension

Manolis, AJ; Rosei, EA; Coca, A; Cifkova, R; Erdine, SE; Kjeldsen, S; Lip, GY; Narkiewicz, K; Parati, G; Redon, J; Schmieder, R; Tsioufis, C; Mancia, G

New insights into insulin action and resistance in the vasculature

Manrique, C; Lastra, G; Sowers, JR

Role of the renin-angiotensin system in vascular inflammation

Marchesi, C; Paradis, P; Schiffrin, EL

Protective role of vascular smooth muscle cell PPARγ in angiotensin II-induced vascular disease

Marchesi, C; Rehman, A; Rautureau, Y; Kasal, DA; Briet, M; Leibowitz, A; Simeone, SM; Ebrahimian, T; Neves, MF; Offermanns, S; Gonzalez, FJ; Paradis, P; Schiffrin, EL

Adipose tissue renin-angiotensin-aldosterone system (RAAS) and progression of insulin resistance

Marcus, Y; Shefer, G; Stern, N

Bcl10 mediates angiotensin II-induced cardiac damage and electrical remodeling

Markó, L; Henke, N; Park, JK; Spallek, B; Qadri, F; Balogh, A; Apel, IJ; Oravecz-Wilson, KI; Choi, M; Przybyl, L; Binger, KJ; Haase, N; Wilck, N; Heuser, A; Fokuhl, V; Ruland, J; Lucas, PC; McAllister-Lucas, LM; Luft, FC; Dechend, R; Müller, DN

Interferon-γ signaling inhibition ameliorates angiotensin II-induced cardiac damage

Markó, L; Kvakan, H; Park, JK; Qadri, F; Spallek, B; Binger, KJ; Bowman, EP; Kleinewietfeld, M; Fokuhl, V; Dechend, R; Müller, DN

Sonic hedgehog carried by microparticles corrects angiotensin II-induced hypertension and endothelial dysfunction in mice

Marrachelli, VG; Mastronardi, ML; Sarr, M; Soleti, R; Leonetti, D; Martínez, MC; Andriantsitohaina, R

Activation of the hexosamine biosynthesis pathway and protein O-GlcNAcylation modulate hypertrophic and cell signaling pathways in cardiomyocytes from diabetic mice

Marsh, SA; Dell’Italia, LJ; Chatham, JC

Deficiency of MMP17/MT4-MMP proteolytic activity predisposes to aortic aneurysm in mice

Martín-Alonso, M; García-Redondo, AB; Guo, D; Camafeita, E; Martínez, F; Alfranca, A; Méndez-Barbero, N; Pollán, Á; Sánchez-Camacho, C; Denhardt, DT; Seiki, M; Vázquez, J; Salaices, M; Redondo, JM; Milewicz, D; Arroyo, AG

Lysyl Oxidase Induces Vascular Oxidative Stress and Contributes to Arterial Stiffness and Abnormal Elastin Structure in Hypertension: Role of p38MAPK

Martínez-Revelles, S; García-Redondo, AB; Avendaño, MS; Varona, S; Palao, T; Orriols, M; Roque, FR; Fortuño, A; Touyz, RM; Martínez-González, J; Salaices, M; Rodríguez, C; Briones, AM

Late-life enalapril administration induces nitric oxide-dependent and independent metabolic adaptations in the rat skeletal muscle

Marzetti, E; Calvani, R; DuPree, J; Lees, HA; Giovannini, S; Seo, DO; Buford, TW; Sweet, K; Morgan, D; Strehler, KYE; Diz, D; Borst, SE; Moningka, N; Krotova, K; Carter, CS

Adipose angiotensinogen is involved in adipose tissue growth and blood pressure regulation

Massiéra, F; Bloch-Faure, M; Ceiler, D; Murakami, K; f*ckamizu, A; Gasc, JM; Quignard-Boulange, A; Negrel, R; Ailhaud, G; Seydoux, J; Meneton, P; Teboul, M

Angiotensinogen-deficient mice exhibit impairment of diet-induced weight gain with alteration in adipose tissue development and increased locomotor activity

Massiera, F; Seydoux, J; Geloen, A; Quignard-Boulange, A; Turban, S; Saint-Marc, P; f*ckamizu, A; Negrel, R; Ailhaud, G; Teboul, M

AT2 receptor activities and pathophysiological implications

Matavelli, LC; Siragy, HM

Angiotensin II type-2 receptor stimulation induces neuronal VEGF synthesis after cerebral ischemia

Mateos, L; Perez-Alvarez, MJ; Wandosell, F

Angiotensin II Activates MCP-1 and Induces Cardiac Hypertrophy and Dysfunction via Toll-like Receptor 4

Matsuda, S; Umemoto, S; Yoshimura, K; Itoh, S; Murata, T; f*ckai, T; Matsuzaki, M

Distinct neural mechanisms for the control of thirst and salt appetite in the subfornical organ

Matsuda, T; Hiyama, TY; Niimura, F; Matsusaka, T; f*ckamizu, A; Kobayashi, K; Kobayashi, K; Noda, M

Targeted deletion or pharmacological inhibition of MMP-2 prevents cardiac rupture after myocardial infarction in mice

Matsumura, S; Iwanaga, S; Mochizuki, S; Okamoto, H; Ogawa, S; Okada, Y

Nox1 is involved in angiotensin II-mediated hypertension: a study in Nox1-deficient mice

Matsuno, K; Yamada, H; Iwata, K; Jin, D; Katsuyama, M; Matsuki, M; Takai, S; Yamanishi, K; Miyazaki, M; Matsubara, H; Yabe-Nishimura, C

Targeted deletion of matrix metalloproteinase 2 ameliorates myocardial remodeling in mice with chronic pressure overload

Matsusaka, H; Ide, T; Matsushima, S; Ikeuchi, M; Kubota, T; Sunagawa, K; Kinugawa, S; Tsutsui, H

Podocyte injury enhances filtration of liver-derived angiotensinogen and renal angiotensin II generation

Matsusaka, T; Niimura, F; Pastan, I; Shintani, A; Nishiyama, A; Ichikawa, I

Liver angiotensinogen is the primary source of renal angiotensin II

Matsusaka, T; Niimura, F; Shimizu, A; Pastan, I; Saito, A; Kobori, H; Nishiyama, A; Ichikawa, I

Deletion of angiotensin II type 2 receptor accelerates adipogenesis in murine mesenchymal stem cells via Wnt10b/beta-catenin signaling

Matsush*ta, K; Wu, Y; Pratt, RE; Dzau, VJ

Inhibition of prolyl hydroxylase domain-containing protein downregulates vascular angiotensin II type 1 receptor

Matsuura, H; Ichiki, T; Ikeda, J; Takeda, K; Miyazaki, R; Hashimoto, T; Narabayashi, E; Kitamoto, S; Tokunou, T; Sunagawa, K

TNF/Ang-II synergy is obligate for fibroinflammatory pathology, but not for changes in cardiorenal function

Mayr, M; Duerrschmid, C; Medrano, G; Taffet, GE; Wang, Y; Entman, ML; Haudek, SB

The CARMA3-Bcl10-MALT1 signalosome promotes angiotensin II-dependent vascular inflammation and atherogenesis

McAllister-Lucas, LM; Jin, X; Gu, S; Siu, K; McDonnell, S; Ruland, J; Delekta, PC; Van Beek, M; Lucas, PC

CARMA3/Bcl10/MALT1-dependent NF-kappaB activation mediates angiotensin II-responsive inflammatory signaling in nonimmune cells

McAllister-Lucas, LM; Ruland, J; Siu, K; Jin, X; Gu, S; Kim, DS; Kuffa, P; Kohrt, D; Mak, TW; Nuñez, G; Lucas, PC

Update on the angiotensin AT(2) receptor

McCarthy, CA; Widdop, RE; Denton, KM; Jones, ES

Angiotensin-(1-7) attenuates angiotensin II-induced cardiac remodeling associated with upregulation of dual-specificity phosphatase 1

McCollum, LT; Gallagher, PE; Tallant, EA

Smooth muscle cell mineralocorticoid receptors: role in vascular function and contribution to cardiovascular disease

McCurley, A; McGraw, A; Pruthi, D; Jaffe, IZ

Direct regulation of blood pressure by smooth muscle cell mineralocorticoid receptors

McCurley, A; Pires, PW; Bender, SB; Aronovitz, M; Zhao, MJ; Metzger, D; Chambon, P; Hill, MA; Dorrance, AM; Mendelsohn, ME; Jaffe, IZ

Inflammation, immunity, and hypertensive end-organ damage

McMaster, WG; Kirabo, A; Madhur, MS; Harrison, DG

The angiotensin receptor-associated protein Atrap is a stimulator of the cardiac Ca2+-ATPase SERCA2a

Mederle, K; Gess, B; Pluteanu, F; Plackic, J; Tiefenbach, KJ; Grill, A; Kockskämper, J; Castrop, H

Gq-coupled receptors as mechanosensors mediating myogenic vasoconstriction

Mederos y Schnitzler, M; Storch, U; Meibers, S; Nurwakagari, P; Breit, A; Essin, K; Gollasch, M; Gudermann, T

Angiotensin II cell signaling: physiological and pathological effects in the cardiovascular system

Mehta, PK; Griendling, KK

Nox and Inflammation in the Vascular Adventitia

Meijles, DN; Pagano, PJ

Sphingosine-1-phosphate signalling-a key player in the pathogenesis of Angiotensin II-induced hypertension

Meissner, A; Miro, F; Jiménez-Altayó, F; Jurado, A; Vila, E; Planas, AM

Angiotensin II mobilizes spleen monocytes to promote the development of abdominal aortic aneurysm in Apoe-/- mice

Mellak, S; Ait-Oufella, H; Esposito, B; Loyer, X; Poirier, M; Tedder, TF; Tedgui, A; Mallat, Z; Potteaux, S

How Does Angiotensin Activate Hypothalamic Neurons Essential for Controlling Sympathetic Activity and Blood Pressure?

Mendelowitz, D

Effect of caveolin-1 scaffolding peptide and 17beta-estradiol on intracellular Ca2+ kinetics evoked by angiotensin II in human vascular smooth muscle cells

Méndez-Bolaina, E; Sánchez-González, J; Ramírez-Sánchez, I; Ocharán-Hernández, E; Núñez-Sánchez, M; Meaney-Mendiolea, E; Meaney, A; Asbun-Bojalil, J; Miliar-García, A; Olivares-Corichi, I; Ceballos-Reyes, G

Regulatory T cells prevent angiotensin II-induced abdominal aortic aneurysm in apolipoprotein E knockout mice

Meng, X; Yang, J; Zhang, K; An, G; Kong, J; Jiang, F; Zhang, Y; Zhang, C

Mechanisms of Hippo pathway regulation

Meng, Z; Moroishi, T; Guan, KL

Hypertension and kidneys: unraveling complex molecular mechanisms underlying hypertensive renal damage

Mennuni, S; Rubattu, S; Pierelli, G; Tocci, G; Fofi, C; Volpe, M

Predisposition to atherosclerosis and aortic aneurysms in mice deficient in kinin B1 receptor and apolipoprotein E

Merino, VF; Todiras, M; Mori, MA; Sales, VM; Fonseca, RG; Saul, V; Tenner, K; Bader, M; Pesquero, JB

Metabolomics in angiotensin II-induced cardiac hypertrophy

Mervaala, E; Biala, A; Merasto, S; Lempiäinen, J; Mattila, I; Martonen, E; Eriksson, O; Louhelainen, M; Finckenberg, P; Kaheinen, P; Muller, DN; Luft, FC; Lapatto, R; Oresic, M

Obligatory role for GPER in cardiovascular aging and disease

Meyer, MR; Fredette, NC; Daniel, C; Sharma, G; Amann, K; Arterburn, JB; Barton, M; Prossnitz, ER

Accumulation of Smooth Muscle 22α Protein Accelerates Senescence of Vascular Smooth Muscle Cells via Stabilization of p53 In Vitro and In Vivo

Miao, SB; Xie, XL; Yin, YJ; Zhao, LL; Zhang, F; Shu, YN; Chen, R; Chen, P; Dong, LH; Lin, YL; Lv, P; Zhang, DD; Nie, X; Xue, ZY; Han, M

Nifedipine attenuation of abdominal aortic aneurysm in hypertensive and non-hypertensive mice: mechanisms and implications

Miao, XN; Siu, KL; Cai, H

L-type calcium channel inhibitor diltiazem prevents aneurysm formation by blood pressure-independent anti-inflammatory effects

Mieth, A; Revermann, M; Babelova, A; Weigert, A; Schermuly, RT; Brandes, RP

G protein coupling and second messenger generation are indispensable for metalloprotease-dependent, heparin-binding epidermal growth factor shedding through angiotensin II type-1 receptor

Mifune, M; Ohtsu, H; Suzuki, H; Nakashima, H; Brailoiu, E; Dun, NJ; Frank, GD; Inagami, T; Higashiyama, S; Thomas, WG; Eckhart, AD; Dempsey, PJ; Eguchi, S

Role of chemokine RANTES in the regulation of perivascular inflammation, T-cell accumulation, and vascular dysfunction in hypertension

Mikolajczyk, TP; Nosalski, R; Szczepaniak, P; Budzyn, K; Osmenda, G; Skiba, D; Sagan, A; Wu, J; Vinh, A; Marvar, PJ; Guzik, B; Podolec, J; Drummond, G; Lob, HE; Harrison, DG; Guzik, TJ

Angiotensin II type 2 receptor-interacting protein prevents vascular senescence

Min, L-J; Mogi, M; Iwanami, J; Jing, F; Tsukuda, K; Ohshima, K; Horiuchi, M

Angiotensin II type 1 receptor-associated protein prevents vascular smooth muscle cell senescence via inactivation of calcineurin/nuclear factor of activated T cells pathway

Min, L-J; Mogi, M; Tamura, K; Iwanami, J; Sakata, A; Fujita, T; Tsukuda, K; Jing, F; Iwai, M; Horiuchi, M

Angiotensin II type 2 receptor deletion enhances vascular senescence by methyl methanesulfonate sensitive 2 inhibition

Min, LJ; Mogi, M; Iwanami, J; Li, JM; Sakata, A; Fujita, T; Tsukuda, K; Iwai, M; Horiuchi, M

Endoplasmic reticulum stress as a therapeutic target in cardiovascular disease

Minamino, T; Komuro, I; Kitakaze, M

TM2-TM7 interaction in coupling movement of transmembrane helices to activation of the angiotensin II type-1 receptor

Miura, S; Zhang, J; Boros, J; Karnik, SS

Activation of extracellular signal-activated kinase by angiotensin II-induced Gq-independent epidermal growth factor receptor transactivation

Miura, S; Zhang, J; Matsuo, Y; Saku, K; Karnik, SS

Effect of angiotensin II type 2 receptor on stroke, cognitive impairment and neurodegenerative diseases

Mogi, M; Horiuchi, M

Emerging concepts of regulation of angiotensin II receptors: new players and targets for traditional receptors

Mogi, M; Iwai, M; Horiuchi, M

The β-arrestin-biased ligand TRV120023 inhibits angiotensin II-induced cardiac hypertrophy while preserving enhanced myofilament response to calcium

Monasky, MM; Taglieri, DM; Henze, M; Warren, CM; Utter, MS; Soergel, DG; Violin, JD; Solaro, RJ

Involvement of the platelet-derived growth factor receptor in angiotensin II-induced activation of extracellular regulated kinases 1 and 2 in human mesangial cells

Mondorf, UF; Geiger, H; Herrero, M; Zeuzem, S; Piiper, A

The renin-angiotensin system modulates inflammatory processes in atherosclerosis: evidence from basic research and clinical studies

Montecucco, F; Pende, A; Mach, F

Nicotinamide adenine dinucleotide phosphate reduced oxidase 5 (Nox5) regulation by angiotensin II and endothelin-1 is mediated via calcium/calmodulin-dependent, rac-1-independent pathways in human endothelial cells

Montezano, AC; Burger, D; Paravicini, TM; Chignalia, AZ; Yusuf, H; Almasri, M; He, Y; Callera, GE; He, G; Krause, KH; Lambeth, D; Quinn, MT; Touyz, RM

Reactive oxygen species, vascular Noxs, and hypertension: focus on translational and clinical research

Montezano, AC; Touyz, RM

Resident fibroblast lineages mediate pressure overload-induced cardiac fibrosis

Moore-Morris, T; Guimarães-Camboa, N; Banerjee, I; Zambon, AC; Kisseleva, T; Velayoudon, A; Stallcup, WB; Gu, Y; Dalton, ND; Cedenilla, M; Gomez-Amaro, R; Zhou, B; Brenner, DA; Peterson, KL; Chen, J; Evans, SM

Cardiac fibroblasts: from development to heart failure

Moore-Morris, T; Guimarães-Camboa, N; Yutzey, KE; Pucéat, M; Evans, SM

Alpha1beta1 and integrin-linked kinase interact and modulate angiotensin II effects in vascular smooth muscle cells

Moraes, JA; Frony, AC; Dias, AM; Renovato-Martins, M; Rodrigues, G; Marcinkiewicz, C; Assreuy, J; Barja-Fidalgo, C

Parenteral administration of factor Xa/IIa inhibitors limits experimental aortic aneurysm and atherosclerosis

Moran, CS; Seto, SW; Krishna, SM; Sharma, S; Jose, RJ; Biros, E; Wang, Y; Morton, SK; Golledge, J

Agonist-induced hypertrophy and diastolic dysfunction are associated with selective reduction in glucose oxidation: a metabolic contribution to heart failure with normal ejection fraction

Mori, J; Basu, R; McLean, BA; Das, SK; Zhang, L; Patel, VB; Wagg, CS; Kassiri, Z; Lopaschuk, GD; Oudit, GY

New insights into sodium transport regulation in the distal nephron: role of G-protein coupled receptors

Morla, L; Edwards, A; Crambert, G

The role of angiotensin II in nonalcoholic steatohepatitis

Morris, EM; Fletcher, JA; Thyfault, JP; Rector, RS

Thick ascending limb of the loop of Henle

Mount, DB

Hypertension-Causing Mutation in Peroxisome Proliferator-Activated Receptor γ Impairs Nuclear Export of Nuclear Factor-κB p65 in Vascular Smooth Muscle

Mukohda, M; Lu, KT; Guo, DF; Wu, J; Keen, HL; Liu, X; Ketsawatsomkron, P; Stump, M; Rahmouni, K; Quelle, FW; Sigmund, CD

Expression cloning of type 2 angiotensin II receptor reveals a unique class of seven-transmembrane receptors

Mukoyama, M; Nakajima, M; Horiuchi, M; Sasamura, H; Pratt, RE; Dzau, VJ

Metabolic actions of angiotensin II and insulin: a microvascular endothelial balancing act

Muniyappa, R; Yavuz, S

Long-term treatment with an angiotensin II receptor blocker decreases adipocyte size and improves insulin signaling in obese Zucker rats

Muñoz, MC; Giani, JF; Dominici, FP; Turyn, D; Toblli, JE

Role of the Renin-Angiotensin-Aldosterone System beyond Blood Pressure Regulation: Molecular and Cellular Mechanisms Involved in End-Organ Damage during Arterial Hypertension

Muñoz-Durango, N; Fuentes, CA; Castillo, AE; González-Gómez, LM; Vecchiola, A; Fardella, CE; Kalergis, AM

Potential U.S. Population Impact of the 2017 American College of Cardiology/American Heart Association High Blood Pressure Guideline

Muntner, P; Carey, RM; Gidding, S; Jones, DW; Taler, SJ; Wright, JT; Whelton, PK

Role of endothelial Nox2 NADPH oxidase in angiotensin II-induced hypertension and vasomotor dysfunction

Murdoch, CE; Alom-Ruiz, SP; Wang, M; Zhang, M; Walker, S; Yu, B; Brewer, A; Shah, AM

Endothelial NADPH oxidase-2 promotes interstitial cardiac fibrosis and diastolic dysfunction through proinflammatory effects and endothelial-mesenchymal transition

Murdoch, CE; Chaubey, S; Zeng, L; Yu, B; Ivetic, A; Walker, SJ; Vanhoutte, D; Heymans, S; Grieve, DJ; Cave, AC; Brewer, AC; Zhang, M; Shah, AM

Disruption of muscle renin-angiotensin system in AT1a-/- mice enhances muscle function despite reducing muscle mass but compromises repair after injury

Murphy, KT; Allen, AM; Chee, A; Naim, T; Lynch, GS

Isolation of a cDNA encoding the vascular type-1 angiotensin II receptor

Murphy, TJ; Alexander, RW; Griendling, KK; Runge, MS; Bernstein, KE

The crosstalk between insulin and renin-angiotensin-aldosterone signaling systems and its effect on glucose metabolism and diabetes prevention

Muscogiuri, G; Chavez, AO; Gastaldelli, A; Perego, L; Tripathy, D; Saad, MJ; Velloso, L; Folli, F

mTORC1 Signaling Contributes to Drinking But Not Blood Pressure Responses to Brain Angiotensin II

Muta, K; Morgan, DA; Grobe, JL; Sigmund, CD; Rahmouni, K

Angiotensin II induces neutrophil accumulation in vivo through generation and release of CXC chemokines

Nabah, YN; Mateo, T; Estellés, R; Mata, M; Zagorski, J; Sarau, H; Cortijo, J; Morcillo, EJ; Jose, PJ; Sanz, MJ

NADPH oxidases and cardiac remodelling

Nabeebaccus, A; Zhang, M; Shah, AM

Role of blood cell-associated angiotensin II type 1 receptors in the cerebral microvascular response to ischemic stroke during angiotensin-induced hypertension

Nagai, M; Terao, S; Vital, SA; Rodrigues, SF; Yilmaz, G; Granger, DN

Isolation and identification of proangiotensin-12, a possible component of the renin-angiotensin system

Nagata, S; Kato, J; Sasaki, K; Minamino, N; Eto, T; Kitamura, K

MiR-125b Is Critical for Fibroblast-to-Myofibroblast Transition and Cardiac Fibrosis

Nagpal, V; Rai, R; Place, AT; Murphy, SB; Verma, SK; Ghosh, AK; Vaughan, DE

Glucosamine inhibits angiotensin II-induced cytoplasmic Ca2+ elevation in neonatal cardiomyocytes via protein-associated O-linked N-acetylglucosamine

Nagy, T; Champattanachai, V; Marchase, RB; Chatham, JC

How Is the Brain Renin-Angiotensin System Regulated?

Nakagawa, P; Sigmund, CD

Transient Mild Cerebral Ischemia Significantly Deteriorated Cognitive Impairment in a Mouse Model of Alzheimer’s Disease via Angiotensin AT1 Receptor

Nakagawa, T; Hasegawa, Y; Uekawa, K; Senju, S; Nakagata, N; Matsui, K; Kim-Mitsuyama, S

Critical role of apoptosis signal-regulating kinase 1 in aldosterone/salt-induced cardiac inflammation and fibrosis

Nakamura, T; Kataoka, K; f*ckuda, M; Nako, H; Tokutomi, Y; Dong, YF; Ichijo, H; Ogawa, H; Kim-Mitsuyama, S

Novel role of protein kinase C-delta Tyr 311 phosphorylation in vascular smooth muscle cell hypertrophy by angiotensin II

Nakashima, H; Frank, GD; Shirai, H; Hinoki, A; Higuchi, S; Ohtsu, H; Eguchi, K; Sanjay, A; Reyland, ME; Dempsey, PJ; Inagami, T; Eguchi, S

Angiotensin II antagonist prevents electrical remodeling in atrial fibrillation

Nakashima, H; Kumagai, K; Urata, H; Gondo, N; Ideishi, M; Arakawa, K

The IP3 receptor regulates cardiac hypertrophy in response to select stimuli

Nakayama, H; Bodi, I; Maillet, M; DeSantiago, J; Domeier, TL; Mikoshiba, K; Lorenz, JN; Blatter, LA; Bers, DM; Molkentin, JD

Imidapril, an angiotensin-converting enzyme inhibitor, improves insulin sensitivity by enhancing signal transduction via insulin receptor substrate proteins and improving vascular resistance in the Zucker fatty rat

Nawano, M; Anai, M; Funaki, M; Kobayashi, H; Kanda, A; f*ckushima, Y; Inukai, K; Ogihara, T; Sakoda, H; Onishi, Y; Kikuchi, M; Yazaki, Y; Oka, Y; Asano, T

Transcriptomic Analysis Reveals Novel Transcription Factors Associated With Renin-Angiotensin-Aldosterone System in Human Atheroma

Nehme, A; Cerutti, C; Zibara, K

Coming of age: molecular drivers of aging and therapeutic opportunities

Newgard, CB; Sharpless, NE

Angiotensin II, NADPH oxidase, and redox signaling in the vasculature

Nguyen Dinh Cat, A; Montezano, AC; Burger, D; Touyz, RM

Cell signaling of angiotensin II on vascular tone: novel mechanisms

Nguyen Dinh Cat, A; Touyz, RM

Renin, (pro)renin and receptor: an update

Nguyen, G

Short-term nonpressor angiotensin II infusion stimulates sodium transporters in proximal tubule and distal nephron

Nguyen, MTX; Han, J; Ralph, DL; Veiras, LC; McDonough, AA

Ets-1 is a critical transcriptional regulator of reactive oxygen species and p47(phox) gene expression in response to angiotensin II

Ni, W; Zhan, Y; He, H; Maynard, E; Balschi, JA; Oettgen, P

Heterologous down-regulation of angiotensin type 1 receptors by purinergic P2Y2 receptor stimulation through S-nitrosylation of NF-kappaB

Nishida, M; Ogushi, M; Suda, R; Toyotaka, M; Saiki, S; Kitajima, N; Nakaya, M; Kim, KM; Ide, T; Sato, Y; Inoue, K; Kurose, H

Purinergic P2Y6 receptors heterodimerize with angiotensin AT1 receptors to promote angiotensin II-induced hypertension

Nishimura, A; Sunggip, C; Tozaki-Saitoh, H; Shimauchi, T; Numaga-Tomita, T; Hirano, K; Ide, T; Boeynaems, JM; Kurose, H; Tsuda, M; Robaye, B; Inoue, K; Nishida, M

Cilostazol suppresses angiotensin II-induced vasoconstriction via protein kinase A-mediated phosphorylation of the transient receptor potential canonical 6 channel

Nishioka, K; Nishida, M; Ariyoshi, M; Jian, Z; Saiki, S; Hirano, M; Nakaya, M; Sato, Y; Kita, S; Iwamoto, T; Hirano, K; Inoue, R; Kurose, H

Protective effects of endogenous adrenomedullin on cardiac hypertrophy, fibrosis, and renal damage

Niu, P; Shindo, T; Iwata, H; Iimuro, S; Takeda, N; Zhang, Y; Ebihara, A; Suematsu, Y; Kangawa, K; Hirata, Y; Nagai, R

Angiotensin II regulation of adrenocortical gene transcription

Nogueira, EF; Bollag, WB; Rainey, WE

Postprandial fatty acid uptake and adipocyte remodeling in angiotensin type 2 receptor-deficient mice fed a high-fat/high-fructose diet

Noll, C; Labbé, SM; Pinard, S; Shum, M; Bilodeau, L; Chouinard, L; Phoenix, S; Lecomte, R; Carpentier, AC; Gallo-Payet, N

Effects of losartan and simvastatin on monocyte-derived microparticles in hypertensive patients with and without type 2 diabetes mellitus

Nomura, S; Shouzu, A; Omoto, S; Nishikawa, M; Iwasaka, T

A salt-sensing kinase in T lymphocytes, SGK1, drives hypertension and hypertensive end-organ damage

Norlander, AE; Saleh, MA; Pandey, AK; Itani, HA; Wu, J; Xiao, L; Kang, J; Dale, BL; Goleva, SB; Laroumanie, F; Du, L; Harrison, DG; Madhur, MS

Trans-inactivation of receptor tyrosine kinases by novel angiotensin II AT2 receptor-interacting protein, ATIP

Nouet, S; Amzallag, N; Li, JM; Louis, S; Seitz, I; Cui, TX; Alleaume, AM; Di Benedetto, M; Boden, C; Masson, M; Strosberg, AD; Horiuchi, M; Couraud, PO; Nahmias, C

Elastase-induced intracranial aneurysms in hypertensive mice

Nuki, Y; Tsou, TL; Kurihara, C; Kanematsu, M; Kanematsu, Y; Hashimoto, T

Measurement of immunoreactive angiotensin-(1-7) heptapeptide in human blood

Nussberger, J; Brunner, DB; Nyfeler, JA; Linder, L; Brunner, HR

The role of autophagy in vascular biology

Nussenzweig, SC; Verma, S; Finkel, T

Macrophage-derived IL-6 contributes to ANG II-mediated angiotensinogen stimulation in renal proximal tubular cells

O’Leary, R; Penrose, H; Miyata, K; Satou, R

MicroRNA as a novel component of the tissue renin angiotensin system

Obama, T; Eguchi, S

Vascular induction of a disintegrin and metalloprotease 17 by angiotensin II through hypoxia inducible factor 1α

Obama, T; Takayanagi, T; Kobayashi, T; Bourne, AM; Elliott, KJ; Charbonneau, M; Dubois, CM; Eguchi, S

Epidermal growth factor receptor inhibitor protects against abdominal aortic aneurysm in a mouse model

Obama, T; Tsuji, T; Kobayashi, T; f*ckuda, Y; Takayanagi, T; Taro, Y; Kawai, T; Forrester, SJ; Elliott, KJ; Choi, E; Daugherty, A; Rizzo, V; Eguchi, S

Recent insights and therapeutic perspectives of angiotensin-(1-9) in the cardiovascular system

Ocaranza, MP; Michea, L; Chiong, M; Lagos, CF; Lavandero, S; Jalil, JE

MMP-2 mediates angiotensin II-induced hypertension under the transcriptional control of MMP-7 and TACE

Odenbach, J; Wang, X; Cooper, S; Chow, FL; Oka, T; Lopaschuk, G; Kassiri, Z; Fernandez-Patron, C

Deletion of the angiotensin II type 1 receptor-associated protein enhances renal sodium reabsorption and exacerbates angiotensin II-mediated hypertension

Ohsawa, M; Tamura, K; Wakui, H; Maeda, A; Dejima, T; Kanaoka, T; Azushima, K; Uneda, K; Tsurumi-Ikeya, Y; Kobayashi, R; Matsuda, M; Uchida, S; Toya, Y; Kobori, H; Nishiyama, A; Yamash*ta, A; Ishikawa, Y; Umemura, S

Roles of interleukin 17 in angiotensin II type 1 receptor-mediated insulin resistance

Ohshima, K; Mogi, M; Jing, F; Iwanami, J; Tsukuda, K; Min, LJ; Higaki, J; Horiuchi, M

ADAM17 mediates epidermal growth factor receptor transactivation and vascular smooth muscle cell hypertrophy induced by angiotensin II

Ohtsu, H; Dempsey, PJ; Frank, GD; Brailoiu, E; Higuchi, S; Suzuki, H; Nakashima, H; Eguchi, K; Eguchi, S

Central role of Gq in the hypertrophic signal transduction of angiotensin II in vascular smooth muscle cells

Ohtsu, H; Higuchi, S; Shirai, H; Eguchi, K; Suzuki, H; Hinoki, A; Brailoiu, E; Eckhart, AD; Frank, GD; Eguchi, S

Thirst driving and suppressing signals encoded by distinct neural populations in the brain

Oka, Y; Ye, M; Zuker, CS

Agonist-induced interactions between angiotensin AT1 and epidermal growth factor receptors

Olivares-Reyes, JA; Shah, BH; Hernández-Aranda, J; García-Caballero, A; Farshori, MP; García-Sáinz, JA; Catt, KJ

Angiotensin II-induced extracellular signal-regulated kinase 1/2 activation is mediated by protein kinase Cdelta and intracellular calcium in adult rat cardiac fibroblasts

Olson, ER; Shamhart, PE; Naugle, JE; Meszaros, JG

Involvement of apoptosis signal-regulating kinase-1 on angiotensin II-induced monocyte chemoattractant protein-1 expression

Omura, T; Yoshiyama, M; Kim, S; Matsumoto, R; Nakamura, Y; Izumi, Y; Ichijo, H; Sudo, T; Akioka, K; Iwao, H; Takeuchi, K; Yoshikawa, J

p63RhoGEF regulates auto- and paracrine signaling in cardiac fibroblasts

Ongherth, A; Pasch, S; Wuertz, CM; Nowak, K; Kittana, N; Weis, CA; Jatho, A; Vettel, C; Tiburcy, M; Toischer, K; Hasenfuss, G; Zimmermann, WH; Wieland, T; Lutz, S

Identification of a novel cell binding site of periostin involved in tumour growth

Orecchia, P; Conte, R; Balza, E; Castellani, P; Borsi, L; Zardi, L; Mingari, MC; Carnemolla, B

NKCC1 and NKCC2: The pathogenetic role of cation-chloride cotransporters in hypertension

Orlov, SN; Koltsova, SV; Kapilevich, LV; Gusakova, SV; Dulin, NO

Cross-talk of receptor activator of nuclear factor-κB ligand signaling with renin-angiotensin system in vascular calcification

Osako, MK; Nakagami, H; Shimamura, M; Koriyama, H; Nakagami, F; Shimizu, H; Miyake, T; Yoshizumi, M; Rakugi, H; Morish*ta, R

Roles of the (pro)renin receptor in the kidney

Oshima, Y; Morimoto, S; Ichihara, A

Attenuation of inflammatory vascular remodeling by angiotensin II type 1 receptor-associated protein

Osh*ta, A; Iwai, M; Chen, R; Ide, A; Okumura, M; f*ckunaga, S; Yoshii, T; Mogi, M; Higaki, J; Horiuchi, M

MyD88 deficiency attenuates angiotensin II-induced abdominal aortic aneurysm formation independent of signaling through Toll-like receptors 2 and 4

Owens, AP; Rateri, DL; Howatt, DA; Moore, KJ; Tobias, PS; Curtiss, LK; Lu, H; Cassis, LA; Daugherty, A

Angiotensin II induces a region-specific hyperplasia of the ascending aorta through regulation of inhibitor of differentiation 3

Owens, AP; Subramanian, V; Moorleghen, JJ; Guo, Z; McNamara, CA; Cassis, LA; Daugherty, A

Notch activation mediates angiotensin II-induced vascular remodeling by promoting the proliferation and migration of vascular smooth muscle cells

Ozasa, Y; Akazawa, H; Qin, Y; Tateno, K; Ito, K; Kudo-Sakamoto, Y; Yano, M; Yabumoto, C; Naito, AT; Oka, T; Lee, JK; Minamino, T; Nagai, T; Kobayashi, Y; Komuro, I

Crucial role of Rho-nuclear factor-kappaB axis in angiotensin II-induced renal injury

Ozawa, Y; Kobori, H

Sustained renal interstitial macrophage infiltration following chronic angiotensin II infusions

Ozawa, Y; Kobori, H; Suzaki, Y; Navar, LG

Role of endoplasmic reticulum stress in metabolic disease and other disorders

Ozcan, L; Tabas, I

Role of copper transport protein antioxidant 1 in angiotensin II-induced hypertension: a key regulator of extracellular superoxide dismutase

Ozumi, K; Sudhahar, V; Kim, HW; Chen, GF; Kohno, T; Finney, L; Vogt, S; McKinney, RD; Ushio-f*ckai, M; f*ckai, T

AT2 receptors: beneficial counter-regulatory role in cardiovascular and renal function

Padia, SH; Carey, RM

Intrarenal angiotensin III infusion induces natriuresis and angiotensin type 2 receptor translocation in Wistar-Kyoto but not in spontaneously hypertensive rats

Padia, SH; Kemp, BA; Howell, NL; Gildea, JJ; Keller, SR; Carey, RM

Multidimensional Tracking of GPCR Signaling via Peroxidase-Catalyzed Proximity Labeling

Paek, J; Kalocsay, M; Staus, DP; Wingler, L; Pascolutti, R; Paulo, JA; Gygi, SP; Kruse, AC

Activation of the rat renin promoter by HOXD10.PBX1b.PREP1, Ets-1, and the intracellular domain of notch

Pan, L; Glenn, ST; Jones, CA; Gross, KW

MiR-30-regulated autophagy mediates angiotensin II-induced myocardial hypertrophy

Pan, W; Zhong, Y; Cheng, C; Liu, B; Wang, L; Li, A; Xiong, L; Liu, S

GIT1 mediates HDAC5 activation by angiotensin II in vascular smooth muscle cells

Pang, J; Yan, C; Natarajan, K; Cavet, ME; Massett, MP; Yin, G; Berk, BC

Biased ligand of the angiotensin II type 1 receptor in patients with acute heart failure: a randomized, double-blind, placebo-controlled, phase IIB, dose ranging trial (BLAST-AHF)

Pang, PS; Butler, J; Collins, SP; Cotter, G; Davison, BA; Ezekowitz, JA; Filippatos, G; Levy, PD; Metra, M; Ponikowski, P; Teerlink, JR; Voors, AA; Bharucha, D; Goin, K; Soergel, DG; Felker, GM

MicroRNA-155 Exerts Cell-Specific Antiangiogenic but Proarteriogenic Effects During Adaptive Neovascularization

Pankratz, F; Bemtgen, X; Zeiser, R; Leonhardt, F; Kreuzaler, S; Hilgendorf, I; Smolka, C; Helbing, T; Hoefer, I; Esser, JS; Kustermann, M; Moser, M; Bode, C; Grundmann, S

Cardioprotective effects of angiotensin III against ischemic injury via the AT2 receptor and KATP channels

Park, BM; Gao, S; Cha, SA; Park, BH; Kim, SH

Caveolae as plasma membrane sensors, protectors and organizers

Parton, RG; del Pozo, MA

Angiotensin-(1-7): beyond the cardio-renal actions

Passos-Silva, DG; Verano-Braga, T; Santos, RA

RGS1 regulates myeloid cell accumulation in atherosclerosis and aortic aneurysm rupture through altered chemokine signalling

Patel, J; McNeill, E; Douglas, G; Hale, AB; de Bono, J; Lee, R; Iqbal, AJ; Regan-Komito, D; Stylianou, E; Greaves, DR; Channon, KM

Loss of angiotensin-converting enzyme-2 exacerbates diabetic cardiovascular complications and leads to systolic and vascular dysfunction: a critical role of the angiotensin II/AT1 receptor axis

Patel, VB; Bodiga, S; Basu, R; Das, SK; Wang, W; Wang, Z; Lo, J; Grant, MB; Zhong, J; Kassiri, Z; Oudit, GY

Angiotensin II induced proteolytic cleavage of myocardial ACE2 is mediated by TACE/ADAM-17: a positive feedback mechanism in the RAS

Patel, VB; Clarke, N; Wang, Z; Fan, D; Parajuli, N; Basu, R; Putko, B; Kassiri, Z; Turner, AJ; Oudit, GY

Angiotensin II requires zinc and downregulation of the zinc transporters ZnT3 and ZnT10 to induce senescence of vascular smooth muscle cells

Patrushev, N; Seidel-Rogol, B; Salazar, G

Regulation of AT1R expression through HuR by insulin

Paukku, K; Backlund, M; De Boer, RA; Kalkkinen, N; Kontula, KK; Lehtonen, JY

Direct angiotensin II type 2 receptor stimulation in Nω-nitro-l-arginine-methyl ester-induced hypertension: the effect on pulse wave velocity and aortic remodeling

Paulis, L; Becker, ST; Lucht, K; Schwengel, K; Slavic, S; Kaschina, E; Thöne-Reineke, C; Dahlöf, B; Baulmann, J; Unger, T; Steckelings, UM

Angiotensin blockade in diabetic patients decreases insulin resistance-associated low-grade inflammation

Pavlatou, MG; Mastorakos, G; Margeli, A; Kouskouni, E; Tentolouris, N; Katsilambros, N; Chrousos, GP; Papassotiriou, I

Dominant negative PPARγ promotes atherosclerosis, vascular dysfunction, and hypertension through distinct effects in endothelium and vascular muscle

Pelham, CJ; Keen, HL; Lentz, SR; Sigmund, CD

Central Angiotensin-II Increases Blood Pressure and Sympathetic Outflow via Rho Kinase Activation in Conscious Rabbits

Pellegrino, PR; Schiller, AM; Haack, KK; Zucker, IH

Dilated cardiomyopathy and impaired cardiac hypertrophic response to angiotensin II in mice lacking FGF-2

Pellieux, C; Foletti, A; Peduto, G; Aubert, JF; Nussberger, J; Beermann, F; Brunner, HR; Pedrazzini, T

Myocyte-fibroblast communication in cardiac fibrosis and arrhythmias: mechanisms and model systems

Pellman, J; Zhang, J; Sheikh, F

Serum metabolites predict response to angiotensin II receptor blockers in patients with diabetes mellitus

Pena, MJ; Heinzel, A; Rossing, P; Parving, HH; Dallmann, G; Rossing, K; Andersen, S; Mayer, B; Heerspink, HJ

Novel role for endogenous hepatocyte growth factor in the pathogenesis of intracranial aneurysms

Peña-Silva, RA; Chalouhi, N; Wegman-Points, L; Ali, M; Mitchell, I; Pierce, GL; Chu, Y; Ballas, ZK; Heistad, D; Hasan, D

(Pro)renin receptor mediates both angiotensin II-dependent and -independent oxidative stress in neuronal cells

Peng, H; Li, W; Seth, DM; Nair, AR; Francis, J; Feng, Y

Profibrotic Role for Interleukin-4 in Cardiac Remodeling and Dysfunction

Peng, H; Sarwar, Z; Yang, XP; Peterson, EL; Xu, J; Janic, B; Rhaleb, N; Carretero, OA; Rhaleb, NE

Angiotensin II-induced dilated cardiomyopathy in Balb/c but not C57BL/6J mice

Peng, H; Yang, XP; Carretero, OA; Nakagawa, P; D’Ambrosio, M; Leung, P; Xu, J; Peterson, EL; González, GE; Harding, P; Rhaleb, NE

Tumor necrosis factor-alpha-induced AT1 receptor upregulation enhances angiotensin II-mediated cardiac fibroblast responses that favor fibrosis

Peng, J; Gurantz, D; Tran, V; Cowling, RT; Greenberg, BH

Collecting duct (pro)renin receptor targets ENaC to mediate angiotensin II-induced hypertension

Peng, K; Lu, X; Wang, F; Nau, A; Chen, R; Zhou, SF; Yang, T

Novel EGFR inhibitors attenuate cardiac hypertrophy induced by angiotensin II

Peng, K; Tian, X; Qian, Y; Skibba, M; Zou, C; Liu, Z; Wang, J; Xu, Z; Li, X; Liang, G

MAS receptors mediate vasoprotective and atheroprotective effects of candesartan upon the recovery of vascular angiotensin-converting enzyme 2-angiotensin-(1-7)-MAS axis functionality

Pernomian, L; do Prado, AF; Gomes, MS; Pernomian, L; da Silva, CH; Gerlach, RF; de Oliveira, AM

Genetic silencing of Nox2 and Nox4 reveals differential roles of these NADPH oxidase hom*ologues in the vasopressor and dipsogenic effects of brain angiotensin II

Peterson, JR; Burmeister, MA; Tian, X; Zhou, Y; Guruju, MR; Stupinski, JA; Sharma, RV; Davisson, RL

Nampt secreted from cardiomyocytes promotes development of cardiac hypertrophy and adverse ventricular remodeling

Pillai, VB; Sundaresan, NR; Kim, G; Samant, S; Moreno-Vinasco, L; Garcia, JG; Gupta, MP

6β-Hydroxytestosterone, a cytochrome P450 1B1 metabolite of testosterone, contributes to angiotensin II-induced hypertension and its pathogenesis in male mice

Pingili, AK; Kara, M; Khan, NS; Estes, AM; Lin, Z; Li, W; Gonzalez, FJ; Malik, KU

Circulating Exosomes Induced by Cardiac Pressure Overload Contain Functional Angiotensin II Type 1 Receptors

Pironti, G; Strachan, RT; Abraham, D; Mon-Wei Yu, S; Chen, M; Chen, W; Hanada, K; Mao, L; Watson, LJ; Rockman, HA

Fibroblast Angiotensin II Type 1a Receptors Contribute to Angiotensin II-Induced Medial Hyperplasia in the Ascending Aorta

Poduri, A; Rateri, DL; Howatt, DA; Balakrishnan, A; Moorleghen, JJ; Cassis, LA; Daugherty, A

Caveolin-1 ablation reduces the adverse cardiovascular effects of N-omega-nitro-l-arginine methyl ester and angiotensin II

Pojoga, LH; Romero, JR; Yao, TM; Loutraris, P; Ricchiuti, V; Coutinho, P; Guo, C; Lapointe, N; Stone, JR; Adler, GK; Williams, GH

The SIRT2 polymorphism rs10410544 and risk of Alzheimer’s disease in two Caucasian case-control cohorts

Polito, L; Kehoe, PG; Davin, A; Benussi, L; Ghidoni, R; Binetti, G; Quadri, P; Lucca, U; Tettamanti, M; Clerici, F; Bagnoli, S; Galimberti, D; Nacmias, B; Sorbi, S; Guaita, A; Scarpini, E; Mariani, C; Forloni, G; Albani, D

The molecular genetics of sirtuins: association with human longevity and age-related diseases

Polito, L; Kehoe, PG; Forloni, G; Albani, D

Sex differences in T-lymphocyte tissue infiltration and development of angiotensin II hypertension

Pollow, DP; Uhrlaub, J; Romero-Aleshire, M; Sandberg, K; Nikolich-Zugich, J; Brooks, HL; Hay, M

Angiotensin II synergizes with BAFF to promote atheroprotective regulatory B cells

Ponnuswamy, P; Joffre, J; Herbin, O; Esposito, B; Laurans, L; Binder, CJ; Tedder, TF; Zeboudj, L; Loyer, X; Giraud, A; Zhang, Y; Tedgui, A; Mallat, Z; Ait-Oufella, H

Renal nerve stimulation leads to the activation of the Na+/H+ exchanger isoform 3 via angiotensin II type I receptor

Pontes, RB; Crajoinas, RO; Nishi, EE; Oliveira-Sales, EB; Girardi, AC; Campos, RR; Bergamaschi, CT

Crosstalk between the renal sympathetic nerve and intrarenal angiotensinII modulates proximal tubular sodium reabsorption

Pontes, RB; Girardi, AC; Nishi, EE; Campos, RR; Bergamaschi, CT

Angiotensin II type 2 receptor antagonizes angiotensin II type 1 receptor-mediated cardiomyocyte autophagy

Porrello, ER; D’Amore, A; Curl, CL; Allen, AM; Harrap, SB; Thomas, WG; Delbridge, LM

The angiotensin II type 2 (AT2) receptor: an enigmatic seven transmembrane receptor

Porrello, ER; Delbridge, LM; Thomas, WG

The Biological Basis for Cardiac Repair After Myocardial Infarction: From Inflammation to Fibrosis

Prabhu, SD; Frangogiannis, NG

Calcium/calmodulin-dependent kinase II inhibition in smooth muscle reduces angiotensin II-induced hypertension by controlling aortic remodeling and baroreceptor function

Prasad, AM; Morgan, DA; Nuno, DW; Ketsawatsomkron, P; Bair, TB; Venema, AN; Dibbern, ME; Kutschke, WJ; Weiss, RM; Lamping, KG; Chapleau, MW; Sigmund, CD; Rahmouni, K; Grumbach, IM

Differential Control of Calcium Homeostasis and Vascular Reactivity by CaMKII

Prasad, AM; Nuno, DW; Koval, OM; Ketsawatsomkron, P; Li, W; Li, H; Shen, FY; Joiner, ML; Kutschke, W; Weiss, RM; Sigmund, CD; Anderson, ME; Lamping, KG; Grumbach, IM

Aldosterone promotes vascular remodeling by direct effects on smooth muscle cell mineralocorticoid receptors

Pruthi, D; McCurley, A; Aronovitz, M; Galayda, C; Karumanchi, SA; Jaffe, IZ

Oxidized Ca2+/calmodulin-dependent protein kinase II triggers atrial fibrillation

Purohit, A; Rokita, AG; Guan, X; Chen, B; Koval, OM; Voigt, N; Neef, S; Sowa, T; Gao, Z; Luczak, ED; Stefansdottir, H; Behunin, AC; Li, N; El-Accaoui, RN; Yang, B; Swaminathan, PD; Weiss, RM; Wehrens, XHT; Song, L-S; Dobrev, D; Maier, LS; Anderson, ME

Deficiency of angiotensin type 1a receptors in adipocytes reduces differentiation and promotes hypertrophy of adipocytes in lean mice

Putnam, K; Batifoulier-Yiannikouris, F; Bharadwaj, KG; Lewis, E; Karounos, M; Daugherty, A; Cassis, LA

The renin-angiotensin system: a target of and contributor to dyslipidemias, altered glucose homeostasis, and hypertension of the metabolic syndrome

Putnam, K; Shoemaker, R; Yiannikouris, F; Cassis, LA

Angiotensin II infusion-induced inflammation, monocytic fibroblast precursor infiltration, and cardiac fibrosis are pressure dependent

Qi, G; Jia, L; Li, Y; Bian, Y; Cheng, J; Li, H; Xiao, C; Du, J

Adiponectin suppresses angiotensin II-induced inflammation and cardiac fibrosis through activation of macrophage autophagy

Qi, GM; Jia, LX; Li, YL; Li, HH; Du, J

Aberrant mitochondrial fission in neurons induced by protein kinase Cdelta under oxidative stress conditions in vivo

Qi, X; Disatnik, MH; Shen, N; Sobel, RA; Mochly-Rosen, D

Post-translational regulation of endothelial nitric oxide synthase in vascular endothelium

Qian, J; Fulton, D

Myosin phosphatase target subunit 1 (MYPT1) regulates the contraction and relaxation of vascular smooth muscle and maintains blood pressure

Qiao, YN; He, WQ; Chen, CP; Zhang, CH; Zhao, W; Wang, P; Zhang, L; Wu, YZ; Yang, X; Peng, YJ; Gao, JM; Kamm, KE; Stull, JT; Zhu, MS

Src Family Kinases (SFK) Mediate Angiotensin II-Induced Myosin Light Chain Phosphorylation and Hypertension

Qin, B; Zhou, J

Tauroursodeoxycholic Acid Attenuates Angiotensin II Induced Abdominal Aortic Aneurysm Formation in Apolipoprotein E-deficient Mice by Inhibiting Endoplasmic Reticulum Stress

Qin, Y; Wang, Y; Liu, O; Jia, L; Fang, W; Du, J; Wei, Y

Angiotensin II-induced TLR4 mediated abdominal aortic aneurysm in apolipoprotein E knockout mice is dependent on STAT3

Qin, Z; Bagley, J; Sukhova, G; Baur, WE; Park, HJ; Beasley, D; Libby, P; Zhang, Y; Galper, JB

Matrix metalloproteinases and their inhibitors in vascular remodeling and vascular disease

Raffetto, JD; Khalil, RA

Loss of Notch3 Signaling in Vascular Smooth Muscle Cells Promotes Severe Heart Failure Upon Hypertension

Ragot, H; Monfort, A; Baudet, M; Azibani, F; Fazal, L; Merval, R; Polidano, E; Cohen-Solal, A; Delcayre, C; Vodovar, N; Chatziantoniou, C; Samuel, JL

The role of caveolin-1 in cardiovascular regulation

Rahman, A; Swärd, K

beta-Arrestin-biased agonism of the angiotensin receptor induced by mechanical stress

Rakesh, K; Yoo, B; Kim, IM; Salazar, N; Kim, KS; Rockman, HA

Angiotensinergic stimulation of vascular endothelium in mice causes hypotension, bradycardia, and attenuated angiotensin response

Ramchandran, R; Takezako, T; Saad, Y; Stull, L; Fink, B; Yamada, H; Dikalov, S; Harrison, DG; Moravec, C; Karnik, SS

The nephron (pro)renin receptor: function and significance

Ramkumar, N; Kohan, DE

Angiotensin II-mediated hypertension impairs nitric oxide-induced NKCC2 inhibition in thick ascending limbs

Ramseyer, VD; Ortiz, PA; Carretero, OA; Garvin, JL

Endothelial cell-specific deficiency of Ang II type 1a receptors attenuates Ang II-induced ascending aortic aneurysms in LDL receptor-/- mice

Rateri, DL; Moorleghen, JJ; Balakrishnan, A; Owens, AP; Howatt, DA; Subramanian, V; Poduri, A; Charnigo, R; Cassis, LA; Daugherty, A

Depletion of endothelial or smooth muscle cell-specific angiotensin II type 1a receptors does not influence aortic aneurysms or atherosclerosis in LDL receptor deficient mice

Rateri, DL; Moorleghen, JJ; Knight, V; Balakrishnan, A; Howatt, DA; Cassis, LA; Daugherty, A

Regulation of inflammasome signaling

Rathinam, VA; Vanaja, SK; Fitzgerald, KA

Endothelial Nox4 NADPH oxidase enhances vasodilatation and reduces blood pressure in vivo

Ray, R; Murdoch, CE; Wang, M; Santos, CX; Zhang, M; Alom-Ruiz, S; Anilkumar, N; Ouattara, A; Cave, AC; Walker, SJ; Grieve, DJ; Charles, RL; Eaton, P; Brewer, AC; Shah, AM

Mechanisms of disease: local renin-angiotensin-aldosterone systems and the pathogenesis and treatment of cardiovascular disease

Re, RN

A mouse model of heart failure with preserved ejection fraction due to chronic infusion of a low subpressor dose of angiotensin II

Regan, JA; Mauro, AG; Carbone, S; Marchetti, C; Gill, R; Mezzaroma, E; Valle Raleigh, J; Salloum, FN; Van Tassell, BW; Abbate, A; Toldo, S

Myocardial angiotensin receptors in human hearts

Regitz-Zagrosek, V; Fielitz, J; Fleck, E

Angiotensin type 2 receptor agonist compound 21 reduces vascular injury and myocardial fibrosis in stroke-prone spontaneously hypertensive rats

Rehman, A; Leibowitz, A; Yamamoto, N; Rautureau, Y; Paradis, P; Schiffrin, EL

Angiotensin II induces nephrin dephosphorylation and podocyte injury: role of caveolin-1

Ren, Z; Liang, W; Chen, C; Yang, H; Singhal, PC; Ding, G

Is angiotensin II a direct mediator of left ventricular hypertrophy? Time for another look

Reudelhuber, TL; Bernstein, KE; Delafontaine, P

Deletion of mineralocorticoid receptors from macrophages protects against deoxycorticosterone/salt-induced cardiac fibrosis and increased blood pressure

Rickard, AJ; Morgan, J; Tesch, G; Funder, JW; Fuller, PJ; Young, MJ

Renin expression in developing zebrafish is associated with angiogenesis and requires the Notch pathway and endothelium

Rider, SA; Mullins, LJ; Verdon, RF; MacRae, CA; Mullins, JJ

Decreased perivascular fibrosis but not cardiac hypertrophy in ROCK1+/- haploinsufficient mice

Rikitake, Y; Oyama, N; Wang, CY; Noma, K; Satoh, M; Kim, HH; Liao, JK

Angiotensin II stimulates trafficking of NHE3, NaPi2, and associated proteins into the proximal tubule microvilli

Riquier-Brison, AD; Leong, PK; Pihakaski-Maunsbach, K; McDonough, AA

Targeting γ-secretases protect against angiotensin II-induced cardiac hypertrophy

Rivera-Torres, J; Guzmán-Martínez, G; Villa-Bellosta, R; Orbe, J; González-Gómez, C; Serrano, M; Díez, J; Andrés, V; Maraver, A

AT2 Receptor-Interacting Proteins ATIPs in the Brain

Rodrigues-Ferreira, S; le Rouzic, E; Pawlowski, T; Srivastava, A; Margottin-Goguet, F; Nahmias, C

An ATIPical family of angiotensin II AT2 receptor-interacting proteins

Rodrigues-Ferreira, S; Nahmias, C

Interaction between NADPH-oxidase and Rho-kinase in angiotensin II-induced microglial activation

Rodriguez-Perez, AI; Borrajo, A; Rodriguez-Pallares, J; Guerra, MJ; Labandeira-Garcia, JL

Intrarenal Renin-Angiotensin System: Locally Synthesized or Taken up Via Endocytosis?

Roman, RJ; Fan, F; Zhuo, JL

Vascular and Central Activation of Peroxisome Proliferator-Activated Receptor-β Attenuates Angiotensin II-Induced Hypertension: Role of RGS-5

Romero, M; Jiménez, R; Toral, M; León-Gómez, E; Gómez-Gúzman, M; Sánchez, M; Zarzuelo, MJ; Rodríguez-Gómez, I; Rath, G; Tamargo, J; Pérez-Vizcaíno, F; Dessy, C; Duarte, J

Angiotensin inhibition and malignancies: a review

Rosenthal, T; Gavras, I

Inhibition of adipogenesis by Wnt signaling

Ross, SE; Hemati, N; Longo, KA; Bennett, CN; Lucas, PC; Erickson, RL; MacDougald, OA

Impact of diabetic nephropathy and angiotensin II receptor blockade on urinary polypeptide patterns

Rossing, K; Mischak, H; Parving, HH; Christensen, PK; Walden, M; Hillmann, M; Kaiser, T

Alternatively spliced proline-rich cassettes link WNK1 to aldosterone action

Roy, A; Al-Qusairi, L; Donnelly, BF; Ronzaud, C; Marciszyn, AL; Gong, F; Chang, YP; Butterworth, MB; Pastor-Soler, NM; Hallows, KR; Staub, O; Subramanya, AR

Aldosterone mediates activation of the thiazide-sensitive Na-Cl cotransporter through an SGK1 and WNK4 signaling pathway

Rozansky, DJ; Cornwall, T; Subramanya, AR; Rogers, S; Yang, YF; David, LL; Zhu, X; Yang, CL; Ellison, DH

Interactions Between the Immune and the Renin-Angiotensin Systems in Hypertension

Rudemiller, NP; Crowley, SD

C-C Motif Chemokine 5 Attenuates Angiotensin II-Dependent Kidney Injury by Limiting Renal Macrophage Infiltration

Rudemiller, NP; Patel, MB; Zhang, JD; Jeffs, AD; Karlovich, NS; Griffiths, R; Kan, MJ; Buckley, AF; Gunn, MD; Crowley, SD

Nitrated fatty acids suppress angiotensin II-mediated fibrotic remodelling and atrial fibrillation

Rudolph, TK; Ravekes, T; Klinke, A; Friedrichs, K; Mollenhauer, M; Pekarova, M; Ambrozova, G; Martiskova, H; Kaur, JJ; Matthes, B; Schwoerer, A; Woodco*ck, SR; Kubala, L; Freeman, BA; Baldus, S; Rudolph, V

Myeloperoxidase acts as a profibrotic mediator of atrial fibrillation

Rudolph, V; Andrié, RP; Rudolph, TK; Friedrichs, K; Klinke, A; Hirsch-Hoffmann, B; Schwoerer, AP; Lau, D; Fu, X; Klingel, K; Sydow, K; Didié, M; Seniuk, A; von Leitner, EC; Szoecs, K; Schrickel, JW; Treede, H; Wenzel, U; Lewalter, T; Nickenig, G; Zimmermann, WH; Meinertz, T; Böger, RH; Reichenspurner, H; Freeman, BA; Eschenhagen, T; Ehmke, H; Hazen, SL; Willems, S; Baldus, S

Interacting resident epicardium-derived fibroblasts and recruited bone marrow cells form myocardial infarction scar

Ruiz-Villalba, A; Simón, AM; Pogontke, C; Castillo, MI; Abizanda, G; Pelacho, B; Sánchez-Domínguez, R; Segovia, JC; Prósper, F; Pérez-Pomares, JM

The Rho-kinase pathway regulates angiotensin II-induced renal damage

Rupérez, M; Sánchez-López, E; Blanco-Colio, LM; Esteban, V; Rodríguez-Vita, J; Plaza, JJ; Egido, J; Ruiz-Ortega, M

Whole genome expression analysis within the angiotensin II-apolipoprotein E deficient mouse model of abdominal aortic aneurysm

Rush, C; Nyara, M; Moxon, JV; Trollope, A; Cullen, B; Golledge, J

Angiotensin II as a morphogenic cytokine stimulating renal fibrogenesis

Rüster, C; Wolf, G

Long-Term Biased β-Arrestin Signaling Improves Cardiac Structure and Function in Dilated Cardiomyopathy

Ryba, DM; Li, J; Cowan, CL; Russell, B; Wolska, BM; Solaro, RJ

Can angiotensin-converting enzyme inhibitors impact cognitive decline in early stages of Alzheimer’s disease? An overview of research evidence in the elderly patient population

Rygiel, K

Notch mediated epithelial to mesenchymal transformation is associated with increased expression of the Snail transcription factor

Saad, S; Stanners, SR; Yong, R; Tang, O; Pollock, CA

Brain angiotensin II: new developments, unanswered questions and therapeutic opportunities

Saavedra, JM

Evidence to Consider Angiotensin II Receptor Blockers for the Treatment of Early Alzheimer’s Disease

Saavedra, JM

Role of the angiotensin II AT2 receptor in inflammation and oxidative stress: opposing effects in lean and obese Zucker rats

Sabuhi, R; Ali, Q; Asghar, M; Al-Zamily, NR; Hussain, T

Inhibition of NAD(P)H oxidase potentiates AT2 receptor agonist-induced natriuresis in Sprague-Dawley rats

Sabuhi, R; Asghar, M; Hussain, T

Molecular characterization of angiotensin II-induced hypertrophy of cardiac myocytes and hyperplasia of cardiac fibroblasts. Critical role of the AT1 receptor subtype

Sadoshima, J; Izumo, S

Distinct Regulatory Effects of Myeloid Cell and Endothelial Cell NAPDH Oxidase 2 on Blood Pressure

Sag, CM; Schnelle, M; Zhang, J; Murdoch, CE; Kossmann, S; Protti, A; Santos, CXC; Sawyer, G; Zhang, X; Mongue-Din, H; Richards, DA; Brewer, AC; Prysyazhna, O; Maier, LS; Wenzel, P; Eaton, PJ; Shah, AM

Cooperation of SRC-1 and p300 with NF-kappaB and CREB in angiotensin II-induced IL-6 expression in vascular smooth muscle cells

Sahar, S; Reddy, MA; Wong, C; Meng, L; Wang, M; Natarajan, R

Importance of endothelial NF-κB signalling in vascular remodelling and aortic aneurysm formation

Saito, T; Hasegawa, Y; Ishigaki, Y; Yamada, T; Gao, J; Imai, J; Uno, K; Kaneko, K; Ogihara, T; Shimosawa, T; Asano, T; Fujita, T; Oka, Y; Katagiri, H

Local production of angiotensin II in the subfornical organ causes elevated drinking

Sakai, K; Agassandian, K; Morimoto, S; Sinnayah, P; Cassell, MD; Davisson, RL; Sigmund, CD

Perivascular Adipose Tissue Angiotensin II Type 1 Receptor Promotes Vascular Inflammation and Aneurysm Formation

Sakaue, T; Suzuki, J; Hamaguchi, M; Suehiro, C; Tanino, A; Nagao, T; Uetani, T; Aono, J; Nakaoka, H; Kurata, M; Sakaue, T; Okura, T; Yasugi, T; Izutani, H; Higaki, J; Ikeda, S

Baroreceptor reflex regulation in anesthetized transgenic rats with low glia-derived angiotensinogen

Sakima, A; Averill, DB; Kasper, SO; Jackson, L; Ganten, D; Ferrario, CM; Gallagher, PE; Diz, DI

Zinc regulates Nox1 expression through a NF-κB and mitochondrial ROS dependent mechanism to induce senescence of vascular smooth muscle cells

Salazar, G; Huang, J; Feresin, RG; Zhao, Y; Griendling, KK

KLF4 regulates abdominal aortic aneurysm morphology and deletion attenuates aneurysm formation

Salmon, M; Johnston, WF; Woo, A; Pope, NH; Su, G; Upchurch, GR; Owens, GK; Ailawadi, G

Angiotensin II-activated protein kinase C targets caveolae to inhibit aortic ATP-sensitive potassium channels

Sampson, LJ; Davies, LM; Barrett-Jolley, R; Standen, NB; Dart, C

Angiotensin II signaling increases activity of the renal Na-Cl cotransporter through a WNK4-SPAK-dependent pathway

San-Cristobal, P; Pacheco-Alvarez, D; Richardson, C; Ring, AM; Vazquez, N; Rafiqi, FH; Chari, D; Kahle, KT; Leng, Q; Bobadilla, NA; Hebert, SC; Alessi, DR; Lifton, RP; Gamba, G

IL-33 and ST2 comprise a critical biomechanically induced and cardioprotective signaling system

Sanada, S; Hakuno, D; Higgins, LJ; Schreiter, ER; McKenzie, AN; Lee, RT

The angiotensin-receptor blocker candesartan for treatment of acute stroke (SCAST): a randomised, placebo-controlled, double-blind trial

Sandset, EC; Bath, PM; Boysen, G; Jatuzis, D; Kõrv, J; Lüders, S; Murray, GD; Richter, PS; Roine, RO; Terént, A; Thijs, V; Berge, E

ERK and p38 MAPK, but not NF-kappaB, are critically involved in reactive oxygen species-mediated induction of IL-6 by angiotensin II in cardiac fibroblasts

Sano, M; f*ckuda, K; Sato, T; Kawaguchi, H; Suematsu, M; Matsuda, S; Koyasu, S; Matsui, H; Yamauchi-Takihara, K; Harada, M; Saito, Y; Ogawa, S

NOX signaling in molecular cardiovascular mechanisms involved in the blood pressure homeostasis

Santillo, M; Colantuoni, A; Mondola, P; Guida, B; Damiano, S

Hypertension-Linked Pathophysiological Alterations in the Gut

Santisteban, MM; Qi, Y; Zubcevic, J; Kim, S; Yang, T; Shenoy, V; Cole-Jeffrey, CT; Lobaton, GO; Stewart, DC; Rubiano, A; Simmons, CS; Garcia-Pereira, F; Johnson, RD; Pepine, CJ; Raizada, MK

Impairment of in vitro and in vivo heart function in angiotensin-(1-7) receptor MAS knockout mice

Santos, RA; Castro, CH; Gava, E; Pinheiro, SV; Almeida, AP; Paula, RD; Cruz, JS; Ramos, AS; Rosa, KT; Irigoyen, MC; Bader, M; Alenina, N; Kitten, GT; Ferreira, AJ

MicroRNAs and Endothelial (Dys) Function

Santulli, G

The genetic basis for aortic aneurysmal disease

Saratzis, A; Bown, MJ

Cloning and expression of a complementary DNA encoding a bovine adrenal angiotensin II type-1 receptor

Sasaki, K; Yamano, Y; Bardhan, S; Iwai, N; Murray, JJ; Hasegawa, M; Matsuda, Y; Inagami, T

Mesenchymal stem cells: molecular targets for tissue engineering

Satija, NK; Gurudutta, GU; Sharma, S; Afrin, F; Gupta, P; Verma, YK; Singh, VK; Tripathi, RP

ELABELA-APJ axis protects from pressure overload heart failure and angiotensin II-induced cardiac damage

Sato, T; Sato, C; Kadowaki, A; Watanabe, H; Ho, L; Ishida, J; Yamaguchi, T; Kimura, A; f*ckamizu, A; Penninger, JM; Reversade, B; Ito, H; Imai, Y; Kuba, K

Role of stimulated intrarenal angiotensinogen in hypertension

Satou, R; Shao, W; Navar, LG

Deciphering biased-agonism complexity reveals a new active AT1 receptor entity

Saulière, A; Bellot, M; Paris, H; Denis, C; Finana, F; Hansen, JT; Altié, MF; Seguelas, MH; Pathak, A; Hansen, JL; Sénard, JM; Galés, C

Angiotensin II type 1a receptors in subfornical organ contribute towards chronic intermittent hypoxia-associated sustained increase in mean arterial pressure

Saxena, A; Little, JT; Nedungadi, TP; Cunningham, JT

A novel role for calpain in the endothelial dysfunction induced by activation of angiotensin II type 1 receptor signaling

Scalia, R; Gong, Y; Berzins, B; Freund, B; Feather, D; Landesberg, G; Mishra, G

IL-11 is a crucial determinant of cardiovascular fibrosis

Schafer, S; Viswanathan, S; Widjaja, AA; Lim, WW; Moreno-Moral, A; DeLaughter, DM; Ng, B; Patone, G; Chow, K; Khin, E; Tan, J; Chothani, SP; Ye, L; Rackham, OJL; Ko, NSJ; Sahib, NE; Pua, CJ; Zhen, NTG; Xie, C; Wang, M; Maatz, H; Lim, S; Saar, K; Blachut, S; Petretto, E; Schmidt, S; Putoczki, T; Guimarães-Camboa, N; Wakimoto, H; van Heesch, S; Sigmundsson, K; Lim, SL; Soon, JL; Chao, VTT; Chua, YL; Tan, TE; Evans, SM; Loh, YJ; Jamal, MH; Ong, KK; Chua, KC; Ong, BH; Chakaramakkil, MJ; Seidman, JG; Seidman, CE; Hubner, N; Sin, KYK; Cook, SA

BDNF acting in the hypothalamus induces acute pressor responses under permissive control of angiotensin II

Schaich, CL; Wellman, TL; Koi, B; Erdos, B

Imatinib attenuates end-organ damage in hypertensive hom*ozygous TGR(mRen2)27 rats

Schellings, MW; Baumann, M; van Leeuwen, RE; Duisters, RF; Janssen, SH; Schroen, B; Peutz-Kootstra, CJ; Heymans, S; Pinto, YM

Importance of tyrosine phosphorylation in angiotensin II type 1 receptor signaling

Schieffer, B; Paxton, WG; Marrero, MB; Bernstein, KE

Blood pressure reduction and diabetes insipidus in transgenic rats deficient in brain angiotensinogen

Schinke, M; Baltatu, O; Böhm, M; Peters, J; Rascher, W; Bricca, G; Lippoldt, A; Ganten, D; Bader, M

Stretch-activation of angiotensin II type 1a receptors contributes to the myogenic response of mouse mesenteric and renal arteries

Schleifenbaum, J; Kassmann, M; Szijártó, IA; Hercule, HC; Tano, JY; Weinert, S; Heidenreich, M; Pathan, AR; Anistan, YM; Alenina, N; Rusch, NJ; Bader, M; Jentsch, TJ; Gollasch, M

Reduced incidence of new-onset atrial fibrillation with angiotensin II receptor blockade: the VALUE trial

Schmieder, RE; Kjeldsen, SE; Julius, S; McInnes, GT; Zanchetti, A; Hua, TA

Nox4 is a protective reactive oxygen species generating vascular NADPH oxidase

Schröder, K; Zhang, M; Benkhoff, S; Mieth, A; Pliquett, R; Kosowski, J; Kruse, C; Luedike, P; Michaelis, UR; Weissmann, N; Dimmeler, S; Shah, AM; Brandes, RP

α1AMP-activated protein kinase preserves endothelial function during chronic angiotensin II treatment by limiting Nox2 upregulation

Schuhmacher, S; Foretz, M; Knorr, M; Jansen, T; Hortmann, M; Wenzel, P; Oelze, M; Kleschyov, AL; Daiber, A; Keaney, JF; Wegener, G; Lackner, K; Münzel, T; Viollet, B; Schulz, E

Serial analysis of gene expression in mouse kidney following angiotensin II administration

Schwartz, F; Duka, A; Triantafyllidi, E; Johns, C; Duka, I; Cui, J; Gavras, H

Angiotensin AT2-receptor stimulation improves survival and neurological outcome after experimental stroke in mice

Schwengel, K; Namsolleck, P; Lucht, K; Clausen, BH; Lambertsen, KL; Valero-Esquitino, V; Thöne-Reineke, C; Müller, S; Widdop, RE; Denton, KM; Horiuchi, M; Iwai, M; Boato, F; Dahlöf, B; Hallberg, A; Unger, T; Steckelings, UM

Evidence for angiotensin II type 2 receptor-mediated cardiac myocyte enlargement during in vivo pressure overload

Senbonmatsu, T; Ichihara, S; Price, E; Gaffney, FA; Inagami, T

A novel angiotensin II type 2 receptor signaling pathway: possible role in cardiac hypertrophy

Senbonmatsu, T; Saito, T; Landon, EJ; Watanabe, O; Price, E; Roberts, RL; Imboden, H; Fitzgerald, TG; Gaffney, FA; Inagami, T

Role of T lymphocytes in angiotensin II-mediated microvascular thrombosis

Senchenkova, EY; Russell, J; Kurmaeva, E; Ostanin, D; Granger, DN

Translational Relevance and Recent Advances of Animal Models of Abdominal Aortic Aneurysm

Sénémaud, J; Caligiuri, G; Etienne, H; Delbosc, S; Michel, JB; Coscas, R

Key developments in renin-angiotensin-aldosterone system inhibition

Sevá Pessôa, B; van der Lubbe, N; Verdonk, K; Roks, AJ; Hoorn, EJ; Danser, AH

The mystery of membrane organization: composition, regulation and roles of lipid rafts

Sezgin, E; Levental, I; Mayor, S; Eggeling, C

Myeloid Suppressor Cells Accumulate and Regulate Blood Pressure in Hypertension

Shah, KH; Shi, P; Giani, JF; Janjulia, T; Bernstein, EA; Li, Y; Zhao, T; Harrison, DG; Bernstein, KE; Shen, XZ

Phenotype-Specific Treatment of Heart Failure With Preserved Ejection Fraction: A Multiorgan Roadmap

Shah, SJ; Kitzman, DW; Borlaug, BA; van Heerebeek, L; Zile, MR; Kass, DA; Paulus, WJ

BMP type I receptor ALK2 is required for angiotensin II-induced cardiac hypertrophy

Shahid, M; Spagnolli, E; Ernande, L; Thoonen, R; Kolodziej, SA; Leyton, PA; Cheng, J; Tainsh, RE; Mayeur, C; Rhee, DK; Wu, MX; Scherrer-Crosbie, M; Buys, ES; Zapol, WM; Bloch, KD; Bloch, DB

Adipose tissue (P)RR regulates insulin sensitivity, fat mass and body weight

Shamansurova, Z; Tan, P; Ahmed, B; Pepin, E; Seda, O; Lavoie, JL

Angiotensin-II type 1 receptor and NOX2 mediate TCF/LEF and CREB dependent WISP1 induction and cardiomyocyte hypertrophy

Shanmugam, P; Valente, AJ; Prabhu, SD; Venkatesan, B; Yoshida, T; Delafontaine, P; Chandrasekar, B

Divergent roles of matrix metalloproteinase 2 in pathogenesis of thoracic aortic aneurysm

Shen, M; Lee, J; Basu, R; Sakamuri, SS; Wang, X; Fan, D; Kassiri, Z

AKT2 confers protection against aortic aneurysms and dissections

Shen, YH; Zhang, L; Ren, P; Nguyen, MT; Zou, S; Wu, D; Wang, XL; Coselli, JS; LeMaire, SA

Epidermal growth factor receptor signaling mediates aldosterone-induced profibrotic responses in kidney

Sheng, L; Yang, M; Ding, W; Zhang, M; Niu, J; Qiao, Z; Gu, Y

Glial-specific ablation of angiotensinogen lowers arterial pressure in renin and angiotensinogen transgenic mice

Sherrod, M; Davis, DR; Zhou, X; Cassell, MD; Sigmund, CD

Angiotensin II signaling via protein kinase C phosphorylates Kelch-like 3, preventing WNK4 degradation

Shibata, S; Arroyo, JP; Castañeda-Bueno, M; Puthumana, J; Zhang, J; Uchida, S; Stone, KL; Lam, TT; Lifton, RP

Angiotensin-(1-7) protects against the development of aneurysmal subarachnoid hemorrhage in mice

Shimada, K; Furukawa, H; Wada, K; Wei, Y; Tada, Y; Kuwabara, A; Shikata, F; Kanematsu, Y; Lawton, MT; Kitazato, KT; Nagahiro, S; Hashimoto, T

Physiological and pathological cardiac hypertrophy

Shimizu, I; Minamino, T

Fibroblast deletion of ROCK2 attenuates cardiac hypertrophy, fibrosis, and diastolic dysfunction

Shimizu, T; Narang, N; Chen, P; Yu, B; Knapp, M; Janardanan, J; Blair, J; Liao, JK

Tenascin-C may accelerate cardiac fibrosis by activating macrophages via the integrin αVβ3/nuclear factor-κB/interleukin-6 axis

Shimojo, N; Hashizume, R; Kanayama, K; Hara, M; Suzuki, Y; Nishioka, T; Hiroe, M; Yoshida, T; Imanaka-Yoshida, K

Selective Deletion of the Brain-Specific Isoform of Renin Causes Neurogenic Hypertension

Shinohara, K; Liu, X; Morgan, DA; Davis, DR; Sequeira-Lopez, ML; Cassell, MD; Grobe, JL; Rahmouni, K; Sigmund, CD

Selective Deletion of Renin-b in the Brain Alters Drinking and Metabolism

Shinohara, K; Nakagawa, P; Gomez, J; Morgan, DA; Littlejohn, NK; Folchert, MD; Weidemann, BJ; Liu, X; Walsh, SA; Ponto, LL; Rahmouni, K; Grobe, JL; Sigmund, CD

Angiotensin II inhibits glucose uptake of skeletal muscle via the adenosine monophosphate-activated protein kinase pathway

Shinshi, Y; Higashiura, K; Yoshida, D; Togashi, N; Yoshida, H; Miyazaki, Y; Ura, N; Shimamoto, K

NLRP3 Deficiency Improves Angiotensin II-Induced Hypertension But Not Fetal Growth Restriction During Pregnancy

Shirasuna, K; Karasawa, T; Usui, F; Kobayashi, M; Komada, T; Kimura, H; Kawashima, A; Ohkuchi, A; Taniguchi, S; Takahashi, M

The role of the renin–angiotensin system in the pathogenesis of intracranial aneurysms

Shoja, MM; Agutter, PS; Tubbs, RS; Payner, TD; Ghabili, K; Cohen-Gadol, AA

Renin-angiotensin system blockade: a novel therapeutic approach in chronic obstructive pulmonary disease

Shrikrishna, D; Astin, R; Kemp, PR; Hopkinson, NS

Emerging paradigms of β-arrestin-dependent seven transmembrane receptor signaling

Shukla, AK; Xiao, K; Lefkowitz, RJ

Angiotensin II type 2 receptor promotes adipocyte differentiation and restores adipocyte size in high-fat/high-fructose diet-induced insulin resistance in rats

Shum, M; Pinard, S; Guimond, MO; Labbé, SM; Roberge, C; Baillargeon, JP; Langlois, MF; Alterman, M; Wallinder, C; Hallberg, A; Carpentier, AC; Gallo-Payet, N

Angiotensin II Downregulates MicroRNA-145 to Regulate Kruppel-like Factor 4 and Myocardin Expression in Human Coronary Arterial Smooth Muscle Cells under High Glucose Conditions

Shyu, KG; Cheng, WP; Wang, BW

Organelle-Specific Initiation of Autophagy

Sica, V; Galluzzi, L; Bravo-San Pedro, JM; Izzo, V; Maiuri, MC; Kroemer, G

Angiotensin II stimulates cardiac fibroblast migration via the differential regulation of matrixins and RECK

Siddesha, JM; Valente, AJ; Sakamuri, SS; Yoshida, T; Gardner, JD; Somanna, N; Takahashi, C; Noda, M; Chandrasekar, B

Docosahexaenoic acid reverses angiotensin II-induced RECK suppression and cardiac fibroblast migration

Siddesha, JM; Valente, AJ; Yoshida, T; Sakamuri, SS; Delafontaine, P; Iba, H; Noda, M; Chandrasekar, B

The apelin receptor inhibits the angiotensin II type 1 receptor via allosteric trans-inhibition

Siddiquee, K; Hampton, J; McAnally, D; May, L; Smith, L

Vascular transcriptome profiling identifies sphingosine kinase 1 as a modulator of angiotensin II-induced vascular dysfunction

Siedlinski, M; Nosalski, R; Szczepaniak, P; Ludwig-Gałęzowska, AH; Mikołajczyk, T; Filip, M; Osmenda, G; Wilk, G; Nowak, M; Wołkow, P; Guzik, TJ

No Brain Renin-Angiotensin System: Déjà vu All Over Again?

Sigmund, CD; Diz, DI; Chappell, MC

ACE2, angiotensin-(1-7) and Mas receptor axis in inflammation and fibrosis

Simões e Silva, AC; Silveira, KD; Ferreira, AJ; Teixeira, MM

Angiotensin Receptors: Structure, Function, Signaling and Clinical Applications

Singh, KD; Karnik, SS

Dual Activation of TRIF and MyD88 Adaptor Proteins by Angiotensin II Evokes Opposing Effects on Pressure, Cardiac Hypertrophy, and Inflammatory Gene Expression

Singh, MV; Cicha, MZ; Meyerholz, DK; Chapleau, MW; Abboud, FM

TNF-α type 2 receptor mediates renal inflammatory response to chronic angiotensin II administration with high salt intake in mice

Singh, P; Bahrami, L; Castillo, A; Majid, DS

Identification of three human renin mRNA isoforms from alternative tissue-specific transcriptional initiation

Sinn, PL; Sigmund, CD

Protein kinase D1 mediates class IIa histone deacetylase phosphorylation and nuclear extrusion in intestinal epithelial cells: role in mitogenic signaling

Sinnett-Smith, J; Ni, Y; Wang, J; Ming, M; Young, SH; Rozengurt, E

NOX isoforms in the development of abdominal aortic aneurysm

Siu, KL; Li, Q; Zhang, Y; Guo, J; Youn, JY; Du, J; Cai, H

The CD4(+) AT2R(+) T cell subpopulation improves post-infarction remodelling and restores cardiac function

Skorska, A; von Haehling, S; Ludwig, M; Lux, CA; Gaebel, R; Kleiner, G; Klopsch, C; Dong, J; Curato, C; Altarche-Xifró, W; Slavic, S; Unger, T; Steinhoff, G; Li, J; David, R

The subfornical organ: a central nervous system site for actions of circulating leptin

Smith, PM; Chambers, AP; Price, CJ; Ho, W; Hopf, C; Sharkey, KA; Ferguson, AV

Acetylation of cyclophilin A is required for its secretion and vascular cell activation

Soe, NN; Sowden, M; Baskaran, P; Kim, Y; Nigro, P; Smolock, EM; Berk, BC

Cyclophilin A is required for angiotensin II-induced p47phox translocation to caveolae in vascular smooth muscle cells

Soe, NN; Sowden, M; Baskaran, P; Smolock, EM; Kim, Y; Nigro, P; Berk, BC

The Nox1/4 Dual Inhibitor GKT137831 or Nox4 Knockdown Inhibits Angiotensin-II-Induced Adult Mouse Cardiac Fibroblast Proliferation and Migration. AT1 Physically Associates With Nox4

Somanna, NK; Valente, AJ; Krenz, M; Fay, WP; Delafontaine, P; Chandrasekar, B

Myocardial fibrosis in response to Angiotensin II is preceded by the recruitment of mesenchymal progenitor cells

Sopel, MJ; Rosin, NL; Lee, TD; Légaré, JF

Microdomains, Inflammation, and Atherosclerosis

Sorci-Thomas, MG; Thomas, MJ

TLR4 mutant mice are protected from renal fibrosis and chronic kidney disease progression

Souza, ACP; Tsuji, T; Baranova, IN; Bocharov, AV; Wilkins, KJ; Street, JM; Alvarez-Prats, A; Hu, X; Eggerman, T; Yuen, PST; Star, RA

Inhibition of c-Src tyrosine kinase prevents angiotensin II-mediated connexin-43 remodeling and sudden cardiac death

Sovari, AA; Iravanian, S; Dolmatova, E; Jiao, Z; Liu, H; Zandieh, S; Kumar, V; Wang, K; Bernstein, KE; Bonini, MG; Duffy, HS; Dudley, SC

Classical Renin-Angiotensin system in kidney physiology

Sparks, MA; Crowley, SD; Gurley, SB; Mirotsou, M; Coffman, TM

Angiotensin II type 1A receptors in vascular smooth muscle cells do not influence aortic remodeling in hypertension

Sparks, MA; Parsons, KK; Stegbauer, J; Gurley, SB; Vivekanandan-Giri, A; Fortner, CN; Snouwaert, J; Raasch, EW; Griffiths, RC; Haystead, TA; Le, TH; Pennathur, S; Koller, B; Coffman, TM

Vascular Type 1A Angiotensin II Receptors Control BP by Regulating Renal Blood Flow and Urinary Sodium Excretion

Sparks, MA; Stegbauer, J; Chen, D; Gomez, JA; Griffiths, RC; Azad, HA; Herrera, M; Gurley, SB; Coffman, TM

Transcriptional profiling and network analysis of the murine angiotensin II-induced abdominal aortic aneurysm

Spin, JM; Hsu, M; Azuma, J; Tedesco, MM; Deng, A; Dyer, JS; Maegdefessel, L; Dalman, RL; Tsao, PS

Endoplasmic reticulum stress contributes to aortic stiffening via proapoptotic and fibrotic signaling mechanisms

Spitler, KM; Webb, RC

Tumor Necrosis Factor - Alpha Is Essential for Angiotensin II-Induced Ventricular Remodeling: Role for Oxidative Stress

Sriramula, S; Francis, J

Involvement of tumor necrosis factor-alpha in angiotensin II-mediated effects on salt appetite, hypertension, and cardiac hypertrophy

Sriramula, S; Haque, M; Majid, DS; Francis, J

The calcium-dependent protease calpain causes endothelial dysfunction in type 2 diabetes

Stalker, TJ; Gong, Y; Scalia, R

A novel role for calpains in the endothelial dysfunction of hyperglycemia

Stalker, TJ; Skvarka, CB; Scalia, R

Critical role of TNF-α in cerebral aneurysm formation and progression to rupture

Starke, RM; Chalouhi, N; Jabbour, PM; Tjoumakaris, SI; Gonzalez, LF; Rosenwasser, RH; Wada, K; Shimada, K; Hasan, DM; Greig, NH; Owens, GK; Dumont, AS

MMP-12 deficiency attenuates angiotensin II-induced vascular injury, M2 macrophage accumulation, and skin and heart fibrosis

Stawski, L; Haines, P; Fine, A; Rudnicka, L; Trojanowska, M

Efficient liver-specific deletion of a floxed human angiotensinogen transgene by adenoviral delivery of Cre recombinase in vivo

Stec, DE; Davisson, RL; Haskell, RE; Davidson, BL; Sigmund, CD

Lower blood pressure in floxed angiotensinogen mice after adenoviral delivery of Cre-recombinase

Stec, DE; Keen, HL; Sigmund, CD

The angiotensin AT2 receptor in left ventricular hypertrophy

Steckelings, UM; Widdop, RE; Paulis, L; Unger, T

Resistance to hypertension mediated by intercalated cells of the collecting duct

Stegbauer, J; Chen, D; Herrera, M; Sparks, MA; Yang, T; Königshausen, E; Gurley, SB; Coffman, TM

AT1 receptors in the collecting duct directly modulate the concentration of urine

Stegbauer, J; Gurley, SB; Sparks, MA; Woznowski, M; Kohan, DE; Yan, M; Lehrich, RW; Coffman, TM

Astrocytes Contribute to Angiotensin II Stimulation of Hypothalamic Neuronal Activity and Sympathetic Outflow

Stern, JE; Son, S; Biancardi, VC; Zheng, H; Sharma, N; Patel, KP

Astrocytes synthesize angiotensinogen in brain

Stornetta, RL; Hawelu-Johnson, CL; Guyenet, PG; Lynch, KR

Smooth muscle-selective CPI-17 expression increases vascular smooth muscle contraction and blood pressure

Su, W; Xie, Z; Liu, S; Calderon, LE; Guo, Z; Gong, MC

Calpain-2 compensation promotes angiotensin II-induced ascending and abdominal aortic aneurysms in calpain-1 deficient mice

Subramanian, V; Moorleghen, JJ; Balakrishnan, A; Howatt, DA; Chishti, AH; Uchida, HA

Calpain Inhibition Attenuates Angiotensin II-induced Abdominal Aortic Aneurysms and Atherosclerosis in Low-Density Lipoprotein Receptor Deficient Mice

Subramanian, V; Uchida, HA; Ijaz, T; Moorleghen, JJ; Howatt, DA; Balakrishnan, A

Differential roles of endothelin-1 in angiotensin II-induced atherosclerosis and aortic aneurysms in apolipoprotein E-null mice

Suen, RS; Rampersad, SN; Stewart, DJ; Courtman, DW

Angiotensin II, oxidative stress and skeletal muscle wasting

Sukhanov, S; Semprun-Prieto, L; Yoshida, T; Michael Tabony, A; Higashi, Y; Galvez, S; Delafontaine, P

Sex and the renin-angiotensin system: inequality between the sexes in response to RAS stimulation and inhibition

Sullivan, JC

Angiotensin (1-7) receptor antagonism equalizes angiotensin II-induced hypertension in male and female spontaneously hypertensive rats

Sullivan, JC; Bhatia, K; Yamamoto, T; Elmarakby, AA

Complement C1q-induced activation of β-catenin signalling causes hypertensive arterial remodelling

Sumida, T; Naito, AT; Nomura, S; Nakagawa, A; Higo, T; Hashimoto, A; Okada, K; Sakai, T; Ito, M; Yamaguchi, T; Oka, T; Akazawa, H; Lee, JK; Minamino, T; Offermanns, S; Noda, T; Botto, M; Kobayashi, Y; Morita, H; Manabe, I; Nagai, T; Shiojima, I; Komuro, I

Angiotensin type 2 receptors: blood pressure regulation and end organ damage

Sumners, C; de Kloet, AD; Krause, EG; Unger, T; Steckelings, UM

Bone morphogenetic protein-4 mediates cardiac hypertrophy, apoptosis, and fibrosis in experimentally pathological cardiac hypertrophy

Sun, B; Huo, R; Sheng, Y; Li, Y; Xie, X; Chen, C; Liu, HB; Li, N; Li, CB; Guo, WT; Zhu, JX; Yang, BF; Dong, DL

Free Fatty Acids Activate Renin-Angiotensin System in 3T3-L1 Adipocytes through Nuclear Factor-kappa B Pathway

Sun, J; Luo, J; Ruan, Y; Xiu, L; Fang, B; Zhang, H; Wang, M; Chen, H

Angiotensin II stimulates epithelial sodium channels in the cortical collecting duct of the rat kidney

Sun, P; Yue, P; Wang, WH

Deletion of proton-sensing receptor GPR4 associates with lower blood pressure and lower binding of angiotensin II receptor in SFO

Sun, X; Tommasi, E; Molina, D; Sah, R; Brosnihan, KB; Diz, D; Petrovic, S

T-Cell Mineralocorticoid Receptor Controls Blood Pressure by Regulating Interferon-Gamma

Sun, XN; Li, C; Liu, Y; Du, LJ; Zeng, MR; Zheng, XJ; Zhang, WC; Liu, Y; Zhu, M; Kong, D; Zhou, L; Lu, L; Shen, ZX; Yi, Y; Du, L; Qin, M; Liu, X; Hua, Z; Sun, S; Yin, H; Zhou, B; Yu, Y; Zhang, Z; Duan, SZ

Activation of endothelial nitric oxide synthase by the angiotensin II type 1 receptor

Suzuki, H; Eguchi, K; Ohtsu, H; Higuchi, S; Dhobale, S; Frank, GD; Motley, ED; Eguchi, S

Endothelial nitric oxide synthase inhibits G12/13 and rho-kinase activated by the angiotensin II type-1 receptor: implication in vascular migration

Suzuki, H; Kimura, K; Shirai, H; Eguchi, K; Higuchi, S; Hinoki, A; Ishimaru, K; Brailoiu, E; Dhanasekaran, DN; Stemmle, LN; Fields, TA; Frank, GD; Autieri, MV; Eguchi, S

Investigation of the fate of type I angiotensin receptor after biased activation

Szakadáti, G; Tóth, AD; Oláh, I; Erdélyi, LS; Balla, T; Várnai, P; Hunyady, L; Balla, A

Allosteric interactions within the AT1 angiotensin receptor hom*odimer: role of the conserved DRY motif

Szalai, B; Barkai, L; Turu, G; Szidonya, L; Várnai, P; Hunyady, L

Macrophage Phenotype and Function in Different Stages of Atherosclerosis

Tabas, I; Bornfeldt, KE

Protein phosphatase 2C-alpha knockdown reduces angiotensin II-mediated skeletal muscle wasting via restoration of mitochondrial recycling and function

Tabony, AM; Yoshida, T; Sukhanov, S; Delafontaine, P

Photoreleasable ligands to study intracrine angiotensin II signalling

Tadevosyan, A; Létourneau, M; Folch, B; Doucet, N; Villeneuve, LR; Mamarbachi, AM; Pétrin, D; Hébert, TE; Fournier, A; Chatenet, D; Allen, BG; Nattel, S

Intracellular Angiotensin-II Interacts With Nuclear Angiotensin Receptors in Cardiac Fibroblasts and Regulates RNA Synthesis, Cell Proliferation, and Collagen Secretion

Tadevosyan, A; Xiao, J; Surinkaew, S; Naud, P; Merlen, C; Harada, M; Qi, X; Chatenet, D; Fournier, A; Allen, BG; Nattel, S

The C-terminus of the long AKAP13 isoform (AKAP-Lbc) is critical for development of compensatory cardiac hypertrophy

Taglieri, DM; Johnson, KR; Burmeister, BT; Monasky, MM; Spindler, MJ; DeSantiago, J; Banach, K; Conklin, BR; Carnegie, GK

Glucose and angiotensin II-derived endothelial extracellular vesicles regulate endothelial dysfunction via ERK1/2 activation

Taguchi, K; Hida, M; Narimatsu, H; Matsumoto, T; Kobayashi, T

Caveolin-1 negatively regulates a metalloprotease-dependent epidermal growth factor receptor transactivation by angiotensin II

Takaguri, A; Shirai, H; Kimura, K; Hinoki, A; Eguchi, K; Carlile-Klusacek, M; Yang, B; Rizzo, V; Eguchi, S

Noradrenaline receptor mechanisms modulate the angiotensin II-induced water intake in the subfornical organ in rats

Takahashi, M; Tanaka, J

Detrimental Effects of Centrally Administered Angiotensin II are Enhanced in a Mouse Model of Alzheimer Disease Independently ofBlood Pressure

Takane, K; Hasegawa, Y; Lin, B; Koibuchi, N; Cao, C; Yokoo, T; Kim-Mitsuyama, S

PPARdelta-mediated anti-inflammatory mechanisms inhibit angiotensin II-accelerated atherosclerosis

Takata, Y; Liu, J; Yin, F; Collins, AR; Lyon, CJ; Lee, CH; Atkins, AR; Downes, M; Barish, GD; Evans, RM; Hsueh, WA; Tangirala, RK

Tissue Inhibitor of Matrix Metalloproteinase-1 Promotes Myocardial Fibrosis by Mediating CD63-Integrin β1 Interaction

Takawale, A; Zhang, P; Patel, VB; Wang, X; Oudit, G; Kassiri, Z

Constitutive stimulation of vascular smooth muscle cells by angiotensin II derived from an adenovirus encoding a furin-cleavable fusion protein

Takayanagi, T; Bourne, AM; Kimura, K; Takaguri, A; Elliott, KJ; Eguchi, K; Eguchi, S

Caveolin 1 is critical for abdominal aortic aneurysm formation induced by angiotensin II and inhibition of lysyl oxidase

Takayanagi, T; Crawford, KJ; Kobayashi, T; Obama, T; Tsuji, T; Elliott, KJ; Hashimoto, T; Rizzo, V; Eguchi, S

Vascular ADAM17 as a Novel Therapeutic Target in Mediating Cardiovascular Hypertrophy and Perivascular Fibrosis Induced by Angiotensin II

Takayanagi, T; Forrester, SJ; Kawai, T; Obama, T; Tsuji, T; Elliott, KJ; Nuti, E; Rossello, A; Kwok, HF; Scalia, R; Rizzo, V; Eguchi, S

Role of epidermal growth factor receptor and endoplasmic reticulum stress in vascular remodeling induced by angiotensin II

Takayanagi, T; Kawai, T; Forrester, SJ; Obama, T; Tsuji, T; f*ckuda, Y; Elliott, KJ; Tilley, DG; Davisson, RL; Park, JY; Eguchi, S

G(13)-mediated signaling pathway is required for pressure overload-induced cardiac remodeling and heart failure

Takefuji, M; Wirth, A; Lukasova, M; Takefuji, S; Boettger, T; Braun, T; Althoff, T; Offermanns, S; Wettschureck, N

SMAD3 deficiency promotes inflammatory aortic aneurysms in angiotensin II-infused mice via activation of iNOS

Tan, CK; Tan, EH; Luo, B; Huang, CL; Loo, JS; Choong, C; Tan, NS

Prorenin/renin receptor blockade promotes a healthy fat distribution in obese mice

Tan, P; Blais, C; Nguyen, TM; Schiller, PW; Gutkowska, J; Lavoie, JL

Impact of the prorenin/renin receptor on the development of obesity and associated cardiometabolic risk factors

Tan, P; Shamansurova, Z; Bisotto, S; Michel, C; Gauthier, MS; Rabasa-Lhoret, R; Nguyen, TM; Schiller, PW; Gutkowska, J; Lavoie, JL

The novel angiotensin II type 1 receptor (AT1R)-associated protein ATRAP downregulates AT1R and ameliorates cardiomyocyte hypertrophy

Tanaka, Y; Tamura, K; Koide, Y; Sakai, M; Tsurumi, Y; Noda, Y; Umemura, M; Ishigami, T; Uchino, K; Kimura, K; Horiuchi, M; Umemura, S

Cardiac myosin light chain phosphorylation and inotropic effects of a biased ligand, TRV120023, in a dilated cardiomyopathy model

Tarigopula, M; Davis, RT; Mungai, PT; Ryba, DM; Wieczorek, DF; Cowan, CL; Violin, JD; Wolska, BM; Solaro, RJ

Hypertension: renin-angiotensin-aldosterone system alterations

Te Riet, L; van Esch, JH; Roks, AJ; van den Meiracker, AH; Danser, AH

The Wnt/Frizzled pathway as a therapeutic target for cardiac hypertrophy: where do we stand?

Ter Horst, P; Smits, JF; Blankesteijn, WM

G-Protein-Coupled Receptor MrgD Is a Receptor for Angiotensin-(1-7) Involving Adenylyl Cyclase, cAMP, and Phosphokinase A

Tetzner, A; Gebolys, K; Meinert, C; Klein, S; Uhlich, A; Trebicka, J; Villacañas, Ó; Walther, T

NF-κB-mediated integrin-linked kinase regulation in angiotensin II-induced pro-fibrotic process in cardiac fibroblasts

Thakur, S; Li, L; Gupta, S

Pathophysiology of cardiac hypertrophy and heart failure: signaling pathways and novel therapeutic targets

Tham, YK; Bernardo, BC; Ooi, JY; Weeks, KL; McMullen, JR

Control of adipogenesis by the autocrine interplays between angiotensin 1-7/Mas receptor and angiotensin II/AT1 receptor signaling pathways

Than, A; Leow, MK; Chen, P

Deletion of p47phox attenuates angiotensin II-induced abdominal aortic aneurysm formation in apolipoprotein E-deficient mice

Thomas, M; Gavrila, D; McCormick, ML; Miller, FJ; Daugherty, A; Cassis, LA; Dellsperger, KC; Weintraub, NL

Identification of a Ca2+/calmodulin-binding domain within the carboxyl-terminus of the angiotensin II (AT1A) receptor

Thomas, WG; Pipolo, L; Qian, H

The diagnosis and management of aortic dissection

Thrumurthy, SG; Karthikesalingam, A; Patterson, BO; Holt, PJ; Thompson, MM

Blockade of the RAS increases plasma adiponectin in subjects with metabolic syndrome and enhances differentiation and adiponectin expression of human preadipocytes

Tian, F; Luo, R; Zhao, Z; Wu, Y; Ban, D

G protein-dependent and G protein-independent signaling pathways and their impact on cardiac function

Tilley, DG

Role of angiotensin II type 1 receptors in the subfornical organ in the pressor responses to central sodium in rats

Tiruneh, MA; Huang, BS; Leenen, FH

Atypical signaling and functional desensitization response of MAS receptor to peptide ligands

Tirupula, KC; Desnoyer, R; Speth, RC; Karnik, SS

G protein-coupled receptors directly bind filamin A with high affinity and promote filamin phosphorylation

Tirupula, KC; Ithychanda, SS; Mohan, ML; Naga Prasad, SV; Qin, J; Karnik, SS

Telmisartan Modulates Glial Activation: In Vitro and In Vivo Studies

Torika, N; Asraf, K; Danon, A; Apte, RN; Fleisher-Berkovich, S

Role of 20-HETE, TRPC channels, and BKCa in dysregulation of pressure-induced Ca2+ signaling and myogenic constriction of cerebral arteries in aged hypertensive mice

Toth, P; Csiszar, A; Tucsek, Z; Sosnowska, D; Gautam, T; Koller, A; Schwartzman, ML; Sonntag, WE; Ungvari, Z

Redox-dependent MAP kinase signaling by Ang II in vascular smooth muscle cells: role of receptor tyrosine kinase transactivation

Touyz, RM; Cruzado, M; Tabet, F; Yao, G; Salomon, S; Schiffrin, EL

Angiotensin II-dependent chronic hypertension and cardiac hypertrophy are unaffected by gp91phox-containing NADPH oxidase

Touyz, RM; Mercure, C; He, Y; Javeshghani, D; Yao, G; Callera, GE; Yogi, A; Lochard, N; Reudelhuber, TL

Signal transduction mechanisms mediating the physiological and pathophysiological actions of angiotensin II in vascular smooth muscle cells

Touyz, RM; Schiffrin, EL

Increased angiotensin II-mediated Src signaling via epidermal growth factor receptor transactivation is associated with decreased C-terminal Src kinase activity in vascular smooth muscle cells from spontaneously hypertensive rats

Touyz, RM; Wu, XH; He, G; Salomon, S; Schiffrin, EL

c-Src induces phosphorylation and translocation of p47phox: role in superoxide generation by angiotensin II in human vascular smooth muscle cells

Touyz, RM; Yao, G; Schiffrin, EL

Angiotensin II infusion into ApoE-/- mice: a model for aortic dissection rather than abdominal aortic aneurysm?

Trachet, B; Aslanidou, L; Piersigilli, A; Fraga-Silva, RA; Sordet-Dessimoz, J; Villanueva-Perez, P; Stampanoni, MFM; Stergiopulos, N; Segers, P

Cardiac Fibrosis: The Fibroblast Awakens

Travers, JG; Kamal, FA; Robbins, J; Yutzey, KE; Blaxall, BC

β-Arrestin-2 deficiency attenuates abdominal aortic aneurysm formation in mice

Trivedi, DB; Loftin, CD; Clark, J; Myers, P; DeGraff, LM; Cheng, J; Zeldin, DC; Langenbach, R

Oligoclonal CD8+ T cells play a critical role in the development of hypertension

Trott, DW; Thabet, SR; Kirabo, A; Saleh, MA; Itani, H; Norlander, AE; Wu, J; Goldstein, A; Arendshorst, WJ; Madhur, MS; Chen, W; Li, CI; Shyr, Y; Harrison, DG

Angiotensin II activates signal transducer and activators of transcription 3 via Rac1 in atrial myocytes and fibroblasts: implication for the therapeutic effect of statin in atrial structural remodeling

Tsai, CT; Lai, LP; Kuo, KT; Hwang, JJ; Hsieh, CS; Hsu, KL; Tseng, CD; Tseng, YZ; Chiang, FT; Lin, JL

Reactive oxygen species derived from NADPH oxidase 1 and mitochondria mediate angiotensin II-induced smooth muscle cell senescence

Tsai, IC; Pan, ZC; Cheng, HP; Liu, CH; Lin, BT; Jiang, MJ

Enhancement of Adipocyte Browning by Angiotensin II Type 1 Receptor Blockade

Tsukuda, K; Mogi, M; Iwanami, J; Kanno, H; Nakaoka, H; Wang, XL; Bai, HY; Shan, BS; Kukida, M; Higaki, A; Yamauchi, T; Min, LJ; Horiuchi, M

Angiotensin II Stimulation of Cardiac Hypertrophy and Functional Decompensation in Osteoprotegerin-Deficient Mice

Tsuruda, T; Sekita-Hatakeyama, Y; Hao, Y; Sakamoto, S; Kurogi, S; Nakamura, M; Udagawa, N; Funamoto, T; Sekimoto, T; Hatakeyama, K; Chosa, E; Kato, J; Asada, Y; Kitamura, K

Interacting molecule of AT1 receptor, ATRAP, is colocalized with AT1 receptor in the mouse renal tubules

Tsurumi, Y; Tamura, K; Tanaka, Y; Koide, Y; Sakai, M; Yabana, M; Noda, Y; Hashimoto, T; Kihara, M; Hirawa, N; Toya, Y; Kiuchi, Y; Iwai, M; Horiuchi, M; Umemura, S

IRF3 regulates cardiac fibrosis but not hypertrophy in mice during angiotensin II-induced hypertension

Tsushima, K; Osawa, T; Yanai, H; Nakajima, A; Takaoka, A; Manabe, I; Ohba, Y; Imai, Y; Taniguchi, T; Nagai, R

Angiotensin II type 2 receptor overexpression activates the vascular kinin system and causes vasodilation

Tsutsumi, Y; Matsubara, H; Masaki, H; Kurihara, H; Murasawa, S; Takai, S; Miyazaki, M; Nozawa, Y; Ozono, R; Nakagawa, K; Miwa, T; Kawada, N; Mori, Y; Shibasaki, Y; Tanaka, Y; Fujiyama, S; Koyama, Y; Fujiyama, A; Takahashi, H; Iwasaka, T

Total lymphocyte deficiency attenuates AngII-induced atherosclerosis in males but not abdominal aortic aneurysms in apoE deficient mice

Uchida, HA; Kristo, F; Rateri, DL; Lu, H; Charnigo, R; Cassis, LA; Daugherty, A

Long noncoding RNAs in cardiovascular diseases

Uchida, S; Dimmeler, S

Non-ACE pathway-induced angiotensin II production

Uehara, Y; Miura, S; Yahiro, E; Saku, K

Roles of Caveolin-1 in Angiotensin II-Induced Hypertrophy and Inward Remodeling of Cerebral Pial Arterioles

Umesalma, S; Houwen, FK; Baumbach, GL; Chan, SL

The renin angiotensin aldosterone system and insulin resistance in humans

Underwood, PC; Adler, GK

Inflammasome activation by mitochondrial oxidative stress in macrophages leads to the development of angiotensin II-induced aortic aneurysm

Usui, F; Shirasuna, K; Kimura, H; Tatsumi, K; Kawashima, A; Karasawa, T; Yoshimura, K; Aoki, H; Tsutsui, H; Noda, T; Sagara, J; Taniguchi, S; Takahashi, M

Death-associated protein kinase 3 mediates vascular inflammation and development of hypertension in spontaneously hypertensive rats

Usui, T; Okada, M; Hara, Y; Yamawaki, H

Mechanisms of benefit of angiotensin receptor blockers in coronary atherosclerosis

Vaccari, CS; Lerakis, S; Hammoud, R; Khan, BV

CIKS (Act1 or TRAF3IP2) mediates Angiotensin-II-induced Interleukin-18 expression, and Nox2-dependent cardiomyocyte hypertrophy

Valente, AJ; Clark, RA; Siddesha, JM; Siebenlist, U; Chandrasekar, B

Angiotensin II induces phosphorylation of the thiazide-sensitive sodium chloride cotransporter independent of aldosterone

Van der Lubbe, N; Lim, CH; Fenton, RA; Meima, ME; Jan Danser, AH; Zietse, R; Hoorn, EJ

Cardiac phenotype and angiotensin II levels in AT1a, AT1b, and AT2 receptor single, double, and triple knockouts

Van Esch, JH; Gembardt, F; Sterner-Kock, A; Heringer-Walther, S; Le, TH; Lassner, D; Stijnen, T; Coffman, TM; Schultheiss, HP; Danser, AH; Walther, T

The art of microRNA research

Van Rooij, E

Brain Renin-Angiotensin System: Does It Exist?

Van Thiel, BS; Góes Martini, A; Te Riet, L; Severs, D; Uijl, E; Garrelds, IM; Leijten, FPJ; van der Pluijm, I; Essers, J; Qadri, F; Alenina, N; Bader, M; Paulis, L; Rajkovicova, R; Domenig, O; Poglitsch, M; Danser, AHJ

Metformin inhibits monocyte-to-macrophage differentiation via AMPK-mediated inhibition of STAT3 activation: potential role in atherosclerosis

Vasamsetti, SB; Karnewar, S; Kanugula, AK; Thatipalli, AR; Kumar, JM; Kotamraju, S

Genetics: influence of TOR kinase on lifespan in C. elegans

Vellai, T; Takacs-Vellai, K; Zhang, Y; Kovacs, AL; Orosz, L; Müller, F

Cross-talk between the insulin and angiotensin signaling systems

Velloso, LA; Folli, F; Sun, XJ; White, MF; Saad, MJ; Kahn, CR

Angiotensin II-induced association of phospholipase Cgamma1 with the G-protein-coupled AT1 receptor

Venema, RC; Ju, H; Venema, VJ; Schieffer, B; Harp, JB; Ling, BN; Eaton, DC; Marrero, MB

The renin-angiotensin-aldosterone system in pre-eclampsia: the delicate balance between good and bad

Verdonk, K; Visser, W; Van Den Meiracker, AH; Danser, AH

The biological functions of miRNAs: lessons from in vivo studies

Vidigal, JA; Ventura, A

Inhibition and genetic ablation of the B7/CD28 T-cell costimulation axis prevents experimental hypertension

Vinh, A; Chen, W; Blinder, Y; Weiss, D; Taylor, WR; Goronzy, JJ; Weyand, CM; Harrison, DG; Guzik, TJ

Selectively engaging β-arrestins at the angiotensin II type 1 receptor reduces blood pressure and increases cardiac performance

Violin, JD; DeWire, SM; Yamash*ta, D; Rominger, DH; Nguyen, L; Schiller, K; Whalen, EJ; Gowen, M; Lark, MW

Mechanisms underlying the cerebral microvascular responses to angiotensin II-induced hypertension

Vital, SA; Terao, S; Nagai, M; Granger, DN

Angiotensin receptor neprilysin inhibitor LCZ696 attenuates cardiac remodeling and dysfunction after myocardial infarction by reducing cardiac fibrosis and hypertrophy

Von Lueder, TG; Wang, BH; Kompa, AR; Huang, L; Webb, R; Jordaan, P; Atar, D; Krum, H

TRIF adaptor signaling is important in abdominal aortic aneurysm formation

Vorkapic, E; Lundberg, AM; Mäyränpää, MI; Eriksson, P; Wågsäter, D

Angiotensin II, from vasoconstrictor to growth factor: a paradigm shift

Vukelic, S; Griendling, KK

NADPH oxidase 2 mediates angiotensin II-dependent cellular arrhythmias via PKA and CaMKII

Wagner, S; Dantz, C; Flebbe, H; Azizian, A; Sag, CM; Engels, S; Möllencamp, J; Dybkova, N; Islam, T; Shah, AM; Maier, LS

Angiotensin II Peptide Vaccine Protects Ischemic Brain Through Reducing Oxidative Stress

Wakayama, K; Shimamura, M; Suzuki, JI; Watanabe, R; Koriyama, H; Akazawa, H; Nakagami, H; Mochizuki, H; Isobe, M; Morish*ta, R

Cardiac-specific activation of angiotensin II type 1 receptor-associated protein completely suppresses cardiac hypertrophy in chronic angiotensin II-infused mice

Wakui, H; Tamura, K; Tanaka, Y; Matsuda, M; Bai, Y; Dejima, T; Masuda, S; Shigenaga, A; Maeda, A; Mogi, M; Ichihara, N; Kobayashi, Y; Hirawa, N; Ishigami, T; Toya, Y; Yabana, M; Horiuchi, M; Minamisawa, S; Umemura, S

Angiotensin-(1-7) acts as a vasodepressor agent via angiotensin II type 2 receptors in conscious rats

Walters, PE; Gaspari, TA; Widdop, RE

Overexpression of ANO1/TMEM16A, an arterial Ca2+-activated Cl− channel, contributes to spontaneous hypertension

Wang, B; Li, C; Huai, R; Qu, Z

COX-2 mediates angiotensin II-induced (pro)renin receptor expression in the rat renal medulla

Wang, F; Lu, X; Peng, K; Zhou, L; Li, C; Wang, W; Yu, X; Kohan, DE; Zhu, S-F; Yang, T

Angiotensin II slow-pressor hypertension enhances NMDA currents and NOX2-dependent superoxide production in hypothalamic paraventricular neurons

Wang, G; Coleman, CG; Chan, J; Faraco, G; Marques-Lopes, J; Milner, TA; Guruju, MR; Anrather, J; Davisson, RL; Iadecola, C; Pickel, VM

Mineralocorticoid and angiotensin II type 1 receptors in the subfornical organ mediate angiotensin II - induced hypothalamic reactive oxygen species and hypertension

Wang, HW; Huang, BS; White, RA; Chen, A; Ahmad, M; Leenen, FH

NADPH oxidases mediate a cellular “memory” of angiotensin II stress in hypertensive cardiac hypertrophy

Wang, HX; Yang, H; Han, QY; Li, N; Jiang, X; Tian, C; Du, J; Li, HH

LncDisease: a sequence based bioinformatics tool for predicting lncRNA-disease associations

Wang, J; Ma, R; Ma, W; Chen, J; Yang, J; Xi, Y; Cui, Q

The long noncoding RNA CHRF regulates cardiac hypertrophy by targeting miR-489

Wang, K; Liu, F; Zhou, LY; Long, B; Yuan, SM; Wang, Y; Liu, CY; Sun, T; Zhang, XJ; Li, PF

Inhibition of Toll-like receptor 2 reduces cardiac fibrosis by attenuating macrophage-mediated inflammation

Wang, L; Li, YL; Zhang, CC; Cui, W; Wang, X; Xia, Y; Du, J; Li, HH

Protective role of ACE2-Ang-(1-7)-Mas in myocardial fibrosis by downregulating KCa3.1 channel via ERK1/2 pathway

Wang, LP; Fan, SJ; Li, SM; Wang, XJ; Gao, JL; Yang, XH

Matrix metalloproteinases promote arterial remodeling in aging, hypertension, and atherosclerosis

Wang, M; Kim, SH; Monticone, RE; Lakatta, EG

Promyelocytic leukemia zinc finger protein activates GATA4 transcription and mediates cardiac hypertrophic signaling from angiotensin II receptor 2

Wang, N; Frank, GD; Ding, R; Tan, Z; Rachakonda, A; Pandolfi, PP; Senbonmatsu, T; Landon, EJ; Inagami, T

New insights into the roles of Xin repeat-containing proteins in cardiac development, function, and disease

Wang, Q; Lin, JL; Erives, AJ; Lin, CI; Lin, JJ

The orphan receptor TR3 participates in angiotensin II-induced cardiac hypertrophy by controlling mTOR signalling

Wang, RH; He, JP; Su, ML; Luo, J; Xu, M; Du, XD; Chen, HZ; Wang, WJ; Wang, Y; Zhang, N; Zhao, BX; Zhao, WX; Shan, ZG; Han, J; Chang, C; Wu, Q

Src is required for mechanical stretch-induced cardiomyocyte hypertrophy through angiotensin II type 1 receptor-dependent β-arrestin2 pathways

Wang, S; Gong, H; Jiang, G; Ye, Y; Wu, J; You, J; Zhang, G; Sun, A; Komuro, I; Ge, J; Zou, Y

Activation of AMP-activated protein kinase α2 by nicotine instigates formation of abdominal aortic aneurysms in mice in vivo

Wang, S; Zhang, C; Zhang, M; Liang, B; Zhu, H; Lee, J; Viollet, B; Xia, L; Zhang, Y; Zou, M-H

SREBP-1 Mediates Angiotensin II-Induced TGF-β1 Upregulation and Glomerular Fibrosis

Wang, TN; Chen, X; Li, R; Gao, B; Mohammed-Ali, Z; Lu, C; Yum, V; Dickhout, JG; Krepinsky, JC

Essential role of Smad3 in angiotensin II-induced vascular fibrosis

Wang, W; Huang, XR; Canlas, E; Oka, K; Truong, LD; Deng, C; Bhowmick, NA; Ju, W; Bottinger, EP; Lan, HY

Regulation of potassium (K) handling in the renal collecting duct

Wang, W-H; Giebisch, G

Matrix metalloproteinase-2 mediates a mechanism of metabolic cardioprotection consisting of negative regulation of the sterol regulatory element-binding protein-2/3-hydroxy-3-methylglutaryl-CoA reductase pathway in the heart

Wang, X; Berry, E; Hernandez-Anzaldo, S; Takawale, A; Kassiri, Z; Fernandez-Patron, C

Regulation of autophagy and apoptosis in response to angiotensin II in HL-1 cardiomyocytes

Wang, X; Dai, Y; Ding, Z; Khaidakov, M; Mercanti, F; Mehta, JL

Tumor necrosis factor-alpha-converting enzyme is a key regulator of agonist-induced cardiac hypertrophy and fibrosis

Wang, X; Oka, T; Chow, FL; Cooper, SB; Odenbach, J; Lopaschuk, GD; Kassiri, Z; Fernandez-Patron, C

MicroRNA Let-7i negatively regulates cardiac inflammation and fibrosis

Wang, X; Wang, HX; Li, YL; Zhang, CC; Zhou, CY; Wang, L; Xia, YL; Du, J; Li, HH

TGF-beta activity protects against inflammatory aortic aneurysm progression and complications in angiotensin II-infused mice

Wang, Y; Ait-Oufella, H; Herbin, O; Bonnin, P; Ramkhelawon, B; Taleb, S; Huang, J; Offenstadt, G; Combadière, C; Rénia, L; Johnson, JL; Tharaux, PL; Tedgui, A; Mallat, Z

Mouse models of intracranial aneurysm

Wang, Y; Emeto, TI; Lee, J; Marshman, L; Moran, C; Seto, SW; Golledge, J

Klotho gene delivery suppresses Nox2 expression and attenuates oxidative stress in rat aortic smooth muscle cells via the cAMP-PKA pathway

Wang, Y; Kuro-o, M; Sun, Z

Inhibition of diet-induced atherosclerosis and endothelial dysfunction in apolipoprotein E/angiotensin II type 1A receptor double-knockout mice

Wassmann, S; Czech, T; van Eickels, M; Fleming, I; Böhm, M; Nickenig, G

Nicotinamide Phosphoribosyltransferase in Smooth Muscle Cells Maintains Genome Integrity, Resists Aortic Medial Degeneration, and Is Suppressed in Human Thoracic Aortic Aneurysm Disease

Watson, A; Nong, Z; Yin, H; O’Neil, C; Fox, S; Balint, B; Guo, L; Leo, O; Chu, MWA; Gros, R; Pickering, JG

Myofibroblast-mediated mechanisms of pathological remodelling of the heart

Weber, KT; Sun, Y; Bhattacharya, SK; Ahokas, RA; Gerling, IC

NF-κB mediated miR-26a regulation in cardiac fibrosis

Wei, C; Kim, IK; Kumar, S; Jayasinghe, S; Hong, N; Castoldi, G; Catalucci, D; Jones, WK; Gupta, S

Independent beta-arrestin 2 and G protein-mediated pathways for angiotensin II activation of extracellular signal-regulated kinases 1 and 2

Wei, H; Ahn, S; Shenoy, SK; Karnik, SS; Hunyady, L; Luttrell, LM; Lefkowitz, RJ

MicroRNA-101 inhibits rat cardiac hypertrophy by targeting Rab1a

Wei, L; Yuan, M; Zhou, R; Bai, Q; Zhang, W; Zhang, M; Huang, Y; Shi, L

Smad7 inhibits angiotensin II-induced hypertensive cardiac remodelling

Wei, LH; Huang, XR; Zhang, Y; Li, YQ; Chen, HY; Yan, BP; Yu, CM; Lan, HY

Sirtuin 3 Deficiency Accelerates Hypertensive Cardiac Remodeling by Impairing Angiogenesis

Wei, T; Huang, G; Gao, J; Huang, C; Sun, M; Wu, J; Bu, J; Shen, W

Angiotensin II inhibits the ROMK-like small conductance K channel in renal cortical collecting duct during dietary potassium restriction

Wei, Y; Zavilowitz, B; Satlin, LM; Wang, WH

Deoxycorticosterone acetate salt hypertension in apolipoprotein E-/- mice results in accelerated atherosclerosis: the role of angiotensin II

Weiss, D; Taylor, WR

Endothelial MRTF-A mediates angiotensin II induced cardiac hypertrophy

Weng, X; Yu, L; Liang, P; Chen, D; Cheng, X; Yang, Y; Li, L; Zhang, T; Zhou, B; Wu, X; Xu, H; Fang, M; Gao, Y; Chen, Q; Xu, Y

A crosstalk between chromatin remodeling and histone H3K4 methyltransferase complexes in endothelial cells regulates angiotensin II-induced cardiac hypertrophy

Weng, X; Yu, L; Liang, P; Li, L; Dai, X; Zhou, B; Wu, X; Xu, H; Fang, M; Chen, Q; Xu, Y

The Hippo pathway is controlled by Angiotensin II signaling and its reactivation induces apoptosis in podocytes

Wennmann, DO; Vollenbröker, B; Eckart, AK; Bonse, J; Erdmann, F; Wolters, DA; Schenk, LK; Schulze, U; Kremerskothen, J; Weide, T; Pavenstädt, H

Lysozyme M-positive monocytes mediate angiotensin II-induced arterial hypertension and vascular dysfunction

Wenzel, P; Knorr, M; Kossmann, S; Stratmann, J; Hausding, M; Schuhmacher, S; Karbach, SH; Schwenk, M; Yogev, N; Schulz, E; Oelze, M; Grabbe, S; Jonuleit, H; Becker, C; Daiber, A; Waisman, A; Münzel, T

Immune Mechanisms in Arterial Hypertension

Wenzel, U; Turner, JE; Krebs, C; Kurts, C; Harrison, DG; Ehmke, H

Absence of pressure overload induced myocardial hypertrophy after conditional inactivation of Galphaq/Galpha11 in cardiomyocytes

Wettschureck, N; Rütten, H; Zywietz, A; Gehring, D; Wilkie, TM; Chen, J; Chien, KR; Offermanns, S

Angiotensin II-mediated oxidative stress promotes myocardial tissue remodeling in the transgenic (mRen2) 27 Ren2 rat

Whaley-Connell, A; Govindarajan, G; Habibi, J; Hayden, MR; Cooper, SA; Wei, Y; Ma, L; Qazi, M; Link, D; Karuparthi, PR; Stump, C; Ferrario, C; Sowers, JR

Oxidative stress in the cardiorenal metabolic syndrome

Whaley-Connell, A; Sowers, JR

A monomeric G protein-coupled receptor isolated in a high-density lipoprotein particle efficiently activates its G protein

Whorton, MR; Bokoch, MP; Rasmussen, SG; Huang, B; Zare, RN; Kobilka, B; Sunahara, RK

Attenuation of angiotensin II-induced vascular dysfunction and hypertension by overexpression of Thioredoxin 2

Widder, JD; Fraccarollo, D; Galuppo, P; Hansen, JM; Jones, DP; Ertl, G; Bauersachs, J

Reactive oxygen species, Nox and angiotensin II in angiogenesis: implications for retinopathy

Wilkinson-Berka, JL; Rana, I; Armani, R; Agrotis, A

Class I HDACs regulate angiotensin II-dependent cardiac fibrosis via fibroblasts and circulating fibrocytes

Williams, SM; Golden-Mason, L; Ferguson, BS; Schuetze, KB; Cavasin, MA; Demos-Davies, K; Yeager, ME; Stenmark, KR; McKinsey, TA

Angiotensin receptor blockers and angiogenesis: clinical and experimental evidence

Willis, LM; El-Remessy, AB; Somanath, PR; Deremer, DL; fa*gan, SC

Angiotensin II type 1 receptor blockade by telmisartan prevents stress-induced impairment of memory via HPA axis deactivation and up-regulation of brain-derived neurotrophic factor gene expression

Wincewicz, D; Juchniewicz, A; Waszkiewicz, N; Braszko, JJ

G12-G13-LARG-mediated signaling in vascular smooth muscle is required for salt-induced hypertension

Wirth, A; Benyó, Z; Lukasova, M; Leutgeb, B; Wettschureck, N; Gorbey, S; Orsy, P; Horváth, B; Maser-Gluth, C; Greiner, E; Lemmer, B; Schütz, G; Gutkind, JS; Offermanns, S

The renin-angiotensin system and experimental heart failure

Wollert, KC; Drexler, H

Sirtuin activators mimic caloric restriction and delay ageing in metazoans

Wood, JG; Rogina, B; Lavu, S; Howitz, K; Helfand, SL; Tatar, M; Sinclair, D

The brain RAS and Alzheimer’s disease

Wright, JW; Harding, JW

The brain renin-angiotensin system: a diversity of functions and implications for CNS diseases

Wright, JW; Harding, JW

Adipocyte (Pro)Renin-Receptor Deficiency Induces Lipodystrophy, Liver Steatosis and Increases Blood Pressure in Male Mice

Wu, CH; Mohammadmoradi, S; Thompson, J; Su, W; Gong, M; Nguyen, G; Yiannikouris, F

NLRP3 (Nucleotide Oligomerization Domain-Like Receptor Family, Pyrin Domain Containing 3)-Caspase-1 Inflammasome Degrades Contractile Proteins: Implications for Aortic Biomechanical Dysfunction and Aneurysm and Dissection Formation

Wu, D; Ren, P; Zheng, Y; Zhang, L; Xu, G; Xie, W; Lloyd, EE; Zhang, S; Zhang, Q; Curci, JA; Coselli, JS; Milewicz, DM; Shen, YH; LeMaire, SA

Periostin expression induced by oxidative stress contributes to myocardial fibrosis in a rat model of high salt-induced hypertension

Wu, H; Chen, L; Xie, J; Li, R; Li, GN; Chen, QH; Zhang, XL; Kang, LN; Xu, B

Origin of Matrix-Producing Cells That Contribute to Aortic Fibrosis in Hypertension

Wu, J; Montaniel, KR; Saleh, MA; Xiao, L; Chen, W; Owens, GK; Humphrey, JD; Majesky, MW; Paik, DT; Hatzopoulos, AK; Madhur, MS; Harrison, DG

Inflammation and mechanical stretch promote aortic stiffening in hypertension through activation of p38 mitogen-activated protein kinase

Wu, J; Thabet, SR; Kirabo, A; Trott, DW; Saleh, MA; Xiao, L; Madhur, MS; Chen, W; Harrison, DG

S100a8/a9 released by CD11b+Gr1+ neutrophils activates cardiac fibroblasts to initiate angiotensin II-Induced cardiac inflammation and injury

Wu, Y; Li, Y; Zhang, C; A, X; Wang, Y; Cui, W; Li, H; Du, J

Vascular Smooth Muscle Cell Signaling Mechanisms for Contraction to Angiotensin II and Endothelin-1

Wynne, BM; Chiao, CW; Webb, RC

Caveolin interacts with the angiotensin II type 1 receptor during exocytic transport but not at the plasma membrane

Wyse, BD; Prior, IA; Qian, H; Morrow, IC; Nixon, S; Muncke, C; Kurzchalia, TV; Thomas, WG; Parton, RG; Hanco*ck, JF

Plasma and Kidney Angiotensin Peptides: Importance of the Aminopeptidase A/Angiotensin III Axis

Wysocki, J; Ye, M; Batlle, D

Absence of p55 TNF receptor reduces atherosclerosis, but has no major effect on angiotensin II induced aneurysms in LDL receptor deficient mice

Xanthoulea, S; Thelen, M; Pöttgens, C; Gijbels, MJ; Lutgens, E; de Winther, MP

Angiotensin II type 1 receptor-mediated reduction of angiotensin-converting enzyme 2 activity in the brain impairs baroreflex function in hypertensive mice

Xia, H; Feng, Y; Obr, TD; Hickman, PJ; Lazartigues, E

Brain angiotensin-converting enzyme type 2 shedding contributes to the development of neurogenic hypertension

Xia, H; Sriramula, S; Chhabra, KH; Lazartigues, E

Angiotensin receptor agonistic autoantibodies and hypertension: preeclampsia and beyond

Xia, Y; Kellems, RE

Global phosphorylation analysis of beta-arrestin-mediated signaling downstream of a seven transmembrane receptor (7TMR)

Xiao, K; Sun, J; Kim, J; Rajagopal, S; Zhai, B; Villén, J; Haas, W; Kovacs, JJ; Shukla, AK; Hara, MR; Hernandez, M; Lachmann, A; Zhao, S; Lin, Y; Cheng, Y; Mizuno, K; Ma’ayan, A; Gygi, SP; Lefkowitz, RJ

Renal Denervation Prevents Immune Cell Activation and Renal Inflammation in Angiotensin II-Induced Hypertension

Xiao, L; Kirabo, A; Wu, J; Saleh, MA; Zhu, L; Wang, F; Takahashi, T; Loperena, R; Foss, JD; Mernaugh, RL; Chen, W; Roberts, J; Osborn, JW; Itani, HA; Harrison, DG

Modulation of angiotensin II-induced inflammatory cytokines by the Epac1-Rap1A-NHE3 pathway: implications in renal tubular pathobiology

Xie, P; Joladarashi, D; Dudeja, P; Sun, L; Kanwar, YS

Peroxisome proliferator-activated receptor γ coactivator-1α is a central negative regulator of vascular senescence

Xiong, S; Salazar, G; Patrushev, N; Ma, M; Forouzandeh, F; Hilenski, L; Alexander, RW

PGC-1 alpha serine 570 phosphorylation and GCN5-mediated acetylation by angiotensin II drive catalase down-regulation and vascular hypertrophy

Xiong, S; Salazar, G; San Martin, A; Ahmad, M; Patrushev, N; Hilenski, L; Nazarewicz, RR; Ma, M; Ushio-f*ckai, M; Alexander, RW

Neuron- or glial-specific ablation of secreted renin does not affect renal renin, baseline arterial pressure, or metabolism

Xu, D; Borges, GR; Davis, DR; Agassandian, K; Sequeira Lopez, ML; Gomez, RA; Cassell, MD; Grobe, JL; Sigmund, CD

CCR2 mediates the uptake of bone marrow-derived fibroblast precursors in angiotensin II-induced cardiac fibrosis

Xu, J; Lin, SC; Chen, J; Miao, Y; Taffet, GE; Entman, ML; Wang, Y

Clinical Relevance and Role of Neuronal AT1 Receptors in ADAM17-Mediated ACE2 Shedding in Neurogenic Hypertension

Xu, J; Sriramula, S; Xia, H; Moreno-Walton, L; Culicchia, F; Domenig, O; Poglitsch, M; Lazartigues, E

Effects of cardiac overexpression of the angiotensin II type 2 receptor on remodeling and dysfunction in mice post-myocardial infarction

Xu, J; Sun, Y; Carretero, OA; Zhu, L; Harding, P; Shesely, EG; Dai, X; Rhaleb, NE; Peterson, E; Yang, XP

The critical role of the central nervous system (pro)renin receptor in regulating systemic blood pressure

Xu, Q; Jensen, DD; Peng, H; Feng, Y

IκBβ attenuates angiotensin II-induced cardiovascular inflammation and fibrosis in mice

Xu, S; Zhi, H; Hou, X; Cohen, RA; Jiang, B

Angiotensin II stimulates protein kinase D-dependent histone deacetylase 5 phosphorylation and nuclear export leading to vascular smooth muscle cell hypertrophy

Xu, X; Ha, CH; Wong, C; Wang, W; Hausser, A; Pfizenmaier, K; Olson, EN; McKinsey, TA; Jin, ZG

Inhibition or deletion of angiotensin II type 1 receptor suppresses elastase-induced experimental abdominal aorticaneurysms

Xuan, H; Xu, B; Wang, W; Tanaka, H; Fujimura, N; Miyata, M; Michie, SA; Dalman, RL

Angiotensin II receptor blockade promotes repair of skeletal muscle through down-regulation of aging-promoting C1q expression

Yabumoto, C; Akazawa, H; Yamamoto, R; Yano, M; Kudo-Sakamoto, Y; Sumida, T; Kamo, T; Yagi, H; Shimizu, Y; Saga-Kamo, A; Naito, AT; Oka, T; Lee, JK; Suzuki, J; Sakata, Y; Uejima, E; Komuro, I

Endothelial nitric oxide synthase-independent protective action of statin against angiotensin II-induced atrial remodeling via reduced oxidant injury

Yagi, S; Akaike, M; Aihara, K; Ishikawa, K; Iwase, T; Ikeda, Y; Soeki, T; Yoshida, S; Sumitomo-Ueda, Y; Matsumoto, T; Sata, M

Oxidized LDL (oxLDL) activates the angiotensin II type 1 receptor by binding to the lectin-like oxLDL receptor

Yamamoto, K; Kakino, A; Takesh*ta, H; Hayashi, N; Li, L; Nakano, A; Hanasaki-Yamamoto, H; Fujita, Y; Imaizumi, Y; Toyama-Yokoyama, S; Nakama, C; Kawai, T; Takeda, M; Hongyo, K; Oguro, R; Maekawa, Y; Itoh, N; Takami, Y; Onishi, M; Takeya, Y; Sugimoto, K; Kamide, K; Nakagami, H; Ohishi, M; Kurtz, TW; Sawamura, T; Rakugi, H

Abnormal mechanosensing and cofilin activation promote the progression of ascending aortic aneurysms in mice

Yamashiro, Y; Papke, CL; Kim, J; Ringuette, LJ; Zhang, QJ; Liu, ZP; Mirzaei, H; Wagenseil, JE; Davis, EC; Yanagisawa, H

miR-21-3p regulates cardiac hypertrophic response by targeting histone deacetylase-8

Yan, M; Chen, C; Gong, W; Yin, Z; Zhou, L; Chaugai, S; Wang, DW

Ventricular-specific expression of angiotensin II type 2 receptors causes dilated cardiomyopathy and heart failure in transgenic mice

Yan, X; Price, RL; Nakayama, M; Ito, K; Schuldt, AJ; Manning, WJ; Sanbe, A; Borg, TK; Robbins, J; Lorell, BH

Pressure overload-induced hypertrophy in transgenic mice selectively overexpressing AT2 receptors in ventricular myocytes

Yan, X; Schuldt, AJ; Price, RL; Amende, I; Liu, FF; Okoshi, K; Ho, KK; Pope, AJ; Borg, TK; Lorell, BH; Morgan, JP

The angiotensinogen gene is expressed in both astrocytes and neurons in murine central nervous system

Yang, G; Gray, TS; Sigmund, CD; Cassell, MD

Pathological Ace2-to-Ace enzyme switch in the stressed heart is transcriptionally controlled by the endothelial Brg1-FoxM1 complex

Yang, J; Feng, X; Zhou, Q; Cheng, W; Shang, C; Han, P; Lin, CH; Chen, HS; Quertermous, T; Chang, CP

Distinct MAPK pathways are involved in IL-23 production in dendritic cells cocultured with NK cells in the absence or presence of angiotensin II

Yang, L; Du, C; Chen, T; Li, S; Nie, W; Zhu, W; Fan, F; Zhu, J; Yan, H

Serum-glucocorticoid regulated kinase 1 regulates alternatively activated macrophage polarization contributing to angiotensin II-induced inflammation and cardiac fibrosis

Yang, M; Zheng, J; Miao, Y; Wang, Y; Cui, W; Guo, J; Qiu, S; Han, Y; Jia, L; Li, H; Cheng, J; Du, J

Smooth muscle cell-specific Tgfbr1 deficiency promotes aortic aneurysm formation by stimulating multiple signaling events

Yang, P; Schmit, BM; Fu, C; DeSart, K; Oh, SP; Berceli, SA; Jiang, Z

Acute-phase serum amyloid A: an inflammatory adipokine and potential link between obesity and its metabolic complications

Yang, RZ; Lee, MJ; Hu, H; Pollin, TI; Ryan, AS; Nicklas, BJ; Snitker, S; Horenstein, RB; Hull, K; Goldberg, NH; Goldberg, AP; Shuldiner, AR; Fried, SK; Gong, DW

Gut dysbiosis is linked to hypertension

Yang, T; Santisteban, MM; Rodriguez, V; Li, E; Ahmari, N; Carvajal, JM; Zadeh, M; Gong, M; Qi, Y; Zubcevic, J; Sahay, B; Pepine, CJ; Raizada, MK; Mohamadzadeh, M

Thioredoxin 1 negatively regulates angiotensin II-induced cardiac hypertrophy through upregulation of miR-98/let-7

Yang, Y; Ago, T; Zhai, P; Abdellatif, M; Sadoshima, J

Angiotensin II type 2 receptor overexpression preserves left ventricular function after myocardial infarction

Yang, Z; Bove, CM; French, BA; Epstein, FH; Berr, SS; DiMaria, JM; Gibson, JJ; Carey, RM; Kramer, CM

Angiotensin II type 1a receptor signalling directly contributes to the increased arrhythmogenicity in cardiac hypertrophy

Yasuno, S; Kuwahara, K; Kinosh*ta, H; Yamada, C; Nakagawa, Y; Usami, S; Kuwabara, Y; Ueshima, K; Harada, M; Nishikimi, T; Nakao, K

Interleukin 22 Promotes Blood Pressure Elevation and Endothelial Dysfunction in Angiotensin II-Treated Mice

Ye, J; Ji, Q; Liu, J; Liu, L; Huang, Y; Shi, Y; Shi, L; Wang, M; Liu, M; Feng, Y; Jiang, H; Xu, Y; Wang, Z; Song, J; Lin, Y; Wan, J

Knockdown of angiotensinogen by shRNA-mediated RNA interference inhibits human visceral preadipocytes differentiation

Ye, ZW; Wu, XM; Zhang, LJ; Huang, ZL; Jiang, JG

Adipocyte deficiency of angiotensinogen prevents obesity-induced hypertension in male mice

Yiannikouris, F; Gupte, M; Putnam, K; Thatcher, S; Charnigo, R; Rateri, DL; Daugherty, A; Cassis, LA

Adipocyte-specific deficiency of angiotensinogen decreases plasma angiotensinogen concentration and systolic blood pressure in mice

Yiannikouris, F; Karounos, M; Charnigo, R; English, VL; Rateri, DL; Daugherty, A; Cassis, LA

Deficiency of angiotensinogen in hepatocytes markedly decreases blood pressure in lean and obese male mice

Yiannikouris, F; Wang, Y; Shoemaker, R; Larian, N; Thompson, J; English, VL; Charnigo, R; Su, W; Gong, M; Cassis, LA

Inhibitor κB kinase 2 is a myosin light chain kinase in vascular smooth muscle

Ying, Z; do Carmo, JM; Xiang, L; da Silva, AA; Chen, M; Ryan, MJ; Ostrowski, M; Rajagopalan, S; Hall, JE

PYK2/PDZ-RhoGEF links Ca2+ signaling to RhoA

Ying, Z; Giachini, FR; Tostes, RC; Webb, RC

Foxp3+ regulatory T cells play a protective role in angiotensin II-induced aortic aneurysm formation in mice

Yodoi, K; Yamash*ta, T; Sasaki, N; Kasahara, K; Emoto, T; Matsumoto, T; Kita, T; Sasaki, Y; Mizoguchi, T; Sparwasser, T; Hirata, K

Renal redox-sensitive signaling, but not blood pressure, is attenuated by Nox1 knockout in angiotensin II-dependent chronic hypertension

Yogi, A; Mercure, C; Touyz, J; Callera, GE; Montezano, AC; Aranha, AB; Tostes, RC; Reudelhuber, T; Touyz, RM

An Intronic Enhancer Element Regulates Angiotensin II Type 2 Receptor Expression during Satellite Cell Differentiation, and Its Activity Is Suppressed in Congestive Heart Failure

Yoshida, T; Delafontaine, P

Angiotensin II inhibits satellite cell proliferation and prevents skeletal muscle regeneration

Yoshida, T; Galvez, S; Tiwari, S; Rezk, BM; Semprun-Prieto, L; Higashi, Y; Sukhanov, S; Yablonka-Reuveni, Z; Delafontaine, P

Angiotensin type 2 receptor signaling in satellite cells potentiates skeletal muscle regeneration

Yoshida, T; Huq, TS; Delafontaine, P

IGF-1 prevents ANG II-induced skeletal muscle atrophy via Akt- and Foxo-dependent inhibition of the ubiquitin ligase atrogin-1 expression

Yoshida, T; Semprun-Prieto, L; Sukhanov, S; Delafontaine, P

Molecular mechanisms and signaling pathways of angiotensin II-induced muscle wasting: potential therapeutic targets for cardiac cachexia

Yoshida, T; Tabony, AM; Galvez, S; Mitch, WE; Higashi, Y; Sukhanov, S; Delafontaine, P

High blood pressure reduction reverses angiotensin II type 2 receptor-mediated vasoconstriction into vasodilation in spontaneously hypertensive rats

You, D; Loufrani, L; Baron, C; Levy, BI; Widdop, RE; Henrion, D

Oxidative stress in atrial fibrillation: an emerging role of NADPH oxidase

Youn, J-Y; Zhang, J; Zhang, Y; Chen, H; Liu, D; Ping, P; Weiss, JN; Cai, H

ER stress in the brain subfornical organ mediates angiotensin-dependent hypertension

Young, CN; Cao, X; Guruju, MR; Pierce, JP; Morgan, DA; Wang, G; Iadecola, C; Mark, AL; Davisson, RL

Angiotensin-II, the Brain, and Hypertension: An Update

Young, CN; Davisson, RL

Endoplasmic reticulum and oxidant stress mediate nuclear factor-κB activation in the subfornical organ during angiotensin II hypertension

Young, CN; Li, A; Dong, FN; Horwath, JA; Clark, CG; Davisson, RL

Angiotensin type 1a receptors in the forebrain subfornical organ facilitate leptin-induced weight loss through brown adipose tissue thermogenesis

Young, CN; Morgan, DA; Butler, SD; Rahmouni, K; Gurley, SB; Coffman, TM; Mark, AL; Davisson, RL

Mitofusin 2 inhibits angiotensin II-induced myocardial hypertrophy

Yu, H; Guo, Y; Mi, L; Wang, X; Li, L; Gao, W

Mitochondrial KATP channel involvement in angiotensin II-induced autophagy in vascular smooth muscle cells

Yu, KY; Wang, YP; Wang, LH; Jian, Y; Zhao, XD; Chen, JW; Murao, K; Zhu, W; Dong, L; Wang, GQ; Zhang, GX

Histone Methyltransferase SET1 Mediates Angiotensin II-Induced Endothelin-1 Transcription and Cardiac Hypertrophy in Mice

Yu, L; Yang, G; Weng, X; Liang, P; Li, L; Li, J; Fan, Z; Tian, W; Wu, X; Xu, H; Fang, M; Ji, Y; Li, Y; Chen, Q; Xu, Y

Activation of central PPAR-γ attenuates angiotensin II-induced hypertension

Yu, Y; Xue, BJ; Wei, SG; Zhang, ZH; Beltz, TG; Guo, F; Johnson, AK; Felder, RB

Cardiac hypertrophy is positively regulated by long non-coding RNA PVT1

Yu, Y-H; Hu, Z-Y; Li, M-H; Li, B; Wang, Z-M; Chen, S-L

Mnk1 (Mitogen-Activated Protein Kinase-Interacting Kinase 1) Deficiency Aggravates Cardiac Remodeling in Mice

Yuan, Y; Yan, L; Wu, QQ; Zhou, H; Jin, YG; Bian, ZY; Deng, W; Yang, Z; Shen, DF; Zeng, XF; Wang, SS; Li, H; Tang, QZ

Role of nuclear unphosphorylated STAT3 in angiotensin II type 1 receptor-induced cardiac hypertrophy

Yue, H; Li, W; Desnoyer, R; Karnik, SS

Angiotensin II diminishes the effect of SGK1 on the WNK4-mediated inhibition of ROMK1 channels

Yue, P; Sun, P; Lin, DH; Pan, C; Xing, W; Wang, W

Angiotensin III: a physiological relevant peptide of the renin angiotensin system

Yugandhar, VG; Clark, MA

Deletion of the angiotensin type 2 receptor (AT2R) reduces adipose cell size and protects from diet-induced obesity and insulin resistance

Yvan-Charvet, L; Even, P; Bloch-Faure, M; Guerre-Millo, M; Moustaid-Moussa, N; Ferre, P; Quignard-Boulange, A

Transactivation of the insulin-like growth factor-I receptor by angiotensin II mediates downstream signaling from the angiotensin II type 1 receptor to phosphatidylinositol 3-kinase

Zahradka, P; Litchie, B; Storie, B; Helwer, G

IGF-1 receptor transactivation mediates Src-dependent cortactin phosphorylation in response to angiotensin II

Zahradka, P; Storie, B; Wright, B

Direct activation of ENaC by angiotensin II: recent advances and new insights

Zaika, O; Mamenko, M; Staruschenko, A; Pochynyuk, O

Role of miR-195 in aortic aneurysmal disease

Zampetaki, A; Attia, R; Mayr, U; Gomes, RS; Phinikaridou, A; Yin, X; Langley, SR; Willeit, P; Lu, R; Fanshawe, B; Fava, M; Barallobre-Barreiro, J; Molenaar, C; So, PW; Abbas, A; Jahangiri, M; Waltham, M; Botnar, R; Smith, A; Mayr, M

Altered AT1 receptor regulation of ETB receptors in renal proximal tubule cells of spontaneously hypertensive rats

Zeng, C; Hopfer, U; Asico, LD; Eisner, GM; Felder, RA; Jose, PA

Perturbation of D1 dopamine and AT1 receptor interaction in spontaneously hypertensive rats

Zeng, C; Luo, Y; Asico, LD; Hopfer, U; Eisner, GM; Felder, RA; Jose, PA

Upregulation of Nox4 promotes angiotensin II-induced epidermal growth factor receptor activation and subsequent cardiac hypertrophy by increasing ADAM17 expression

Zeng, SY; Chen, X; Chen, SR; Li, Q; Wang, YH; Zou, J; Cao, WW; Luo, JN; Gao, H; Liu, PQ

Kelch-Like Protein 2 Mediates Angiotensin II-With No Lysine 3 Signaling in the Regulation of Vascular Tonus

Zeniya, M; Morimoto, N; Takahashi, D; Mori, Y; Mori, T; Ando, F; Araki, Y; Yoshizaki, Y; Inoue, Y; Isobe, K; Nomura, N; Oi, K; Nishida, H; Sasaki, S; Sohara, E; Rai, T; Uchida, S

Dietary salt intake regulates WNK3-SPAK-NKCC1 phosphorylation cascade in mouse aorta through angiotensin II

Zeniya, M; Sohara, E; Kita, S; Iwamoto, T; Susa, K; Mori, T; Oi, K; Chiga, M; Takahashi, D; Yang, SS; Lin, SH; Rai, T; Sasaki, S; Uchida, S

Ets-1 is a critical regulator of Ang II-mediated vascular inflammation and remodeling

Zhan, Y; Brown, C; Maynard, E; Anshelevich, A; Ni, W; Ho, IC; Oettgen, P

The counter-regulatory effects of ESE-1 during angiotensin II-mediated vascular inflammation and remodeling

Zhan, Y; Yuan, L; Kondo, M; Oettgen, P

Store-Operated Ca2+ Entry (SOCE) contributes to angiotensin II-induced cardiac fibrosis in cardiac fibroblasts

Zhang, B; Jiang, J; Yue, Z; Liu, S; Ma, Y; Yu, N; Gao, Y; Sun, S; Chen, S; Liu, P

Complement 5a receptor mediates angiotensin II-induced cardiac inflammation and remodeling

Zhang, C; Li, Y; Wang, C; Wu, Y; Cui, W; Miwa, T; Sato, S; Li, H; Song, WC; Du, J

Matricellular protein CCN3 mitigates abdominal aortic aneurysm

Zhang, C; van der Voort, D; Shi, H; Zhang, R; Qing, Y; Hiraoka, S; Takemoto, M; Yokote, K; Moxon, JV; Norman, P; Rittié, L; Kuivaniemi, H; Atkins, GB; Gerson, SL; Shi, GP; Golledge, J; Dong, N; Perbal, B; Prosdocimo, DA; Lin, Z

Structural basis for selectivity and diversity in angiotensin II receptors

Zhang, H; Han, GW; Batyuk, A; Ishchenko, A; White, KL; Patel, N; Sadybekov, A; Zamlynny, B; Rudd, MT; Hollenstein, K; Tolstikova, A; White, TA; Hunter, MS; Weierstall, U; Liu, W; Babaoglu, K; Moore, EL; Katz, RD; Shipman, JM; Garcia-Calvo, M; Sharma, S; Sheth, P; Soisson, SM; Stevens, RC; Katritch, V; Cherezov, V

Structural Basis for Ligand Recognition and Functional Selectivity at Angiotensin Receptor

Zhang, H; Unal, H; Desnoyer, R; Han, GW; Patel, N; Katritch, V; Karnik, SS; Cherezov, V; Stevens, RC

Structure of the Angiotensin receptor revealed by serial femtosecond crystallography

Zhang, H; Unal, H; Gati, C; Han, GW; Liu, W; Zatsepin, NA; James, D; Wang, D; Nelson, G; Weierstall, U; Sawaya, MR; Xu, Q; Messerschmidt, M; Williams, GJ; Boutet, S; Yefanov, OM; White, TA; Wang, C; Ishchenko, A; Tirupula, KC; Desnoyer, R; Coe, J; Conrad, CE; Fromme, P; Stevens, RC; Katritch, V; Karnik, SS; Cherezov, V

Fibulin-2 deficiency attenuates angiotensin II-induced cardiac hypertrophy by reducing transforming growth factor-β signalling

Zhang, H; Wu, J; Dong, H; Khan, SA; Chu, ML; Tsuda, T

Tumor necrosis factor-α produced in the kidney contributes to angiotensin II-dependent hypertension

Zhang, J; Patel, MB; Griffiths, R; Mao, A; Song, YS; Karlovich, NS; Sparks, MA; Jin, H; Wu, M; Lin, EE; Crowley, SD

Interleukin-1 Receptor Activation Potentiates Salt Reabsorption in Angiotensin II-Induced Hypertension via the NKCC2 Co-transporter in the Nephron

Zhang, J; Rudemiller, NP; Patel, MB; Karlovich, NS; Wu, M; McDonough, AA; Griffiths, R; Sparks, MA; Jeffs, AD; Crowley, SD

Type 1 angiotensin receptors on macrophages ameliorate IL-1 receptor-mediated kidney fibrosis

Zhang, JD; Patel, MB; Griffiths, R; Dolber, PC; Ruiz, P; Sparks, MA; Stegbauer, J; Jin, H; Gomez, JA; Buckley, AF; Lefler, WS; Chen, D; Crowley, SD

A novel role for type 1 angiotensin receptors on T lymphocytes to limit target organ damage in hypertension

Zhang, JD; Patel, MB; Song, YS; Griffiths, R; Burchette, J; Ruiz, P; Sparks, MA; Yan, M; Howell, DN; Gomez, JA; Spurney, RF; Coffman, TM; Crowley, SD

Dual pathways for nuclear factor kappaB activation by angiotensin II in vascular smooth muscle: phosphorylation of p65 by IkappaB kinase and ribosomal kinase

Zhang, L; Cheng, J; Ma, Y; Thomas, W; Zhang, J; Du, J

Csk regulates angiotensin II-induced podocyte apoptosis

Zhang, L; Ren, Z; Yang, Q; Ding, G

Contractile Function During Angiotensin-II Activation: Increased Nox2 Activity Modulates Cardiac Calcium Handling via Phospholamban Phosphorylation

Zhang, M; Prosser, BL; Bamboye, MA; Gondim, ANS; Santos, CX; Martin, D; Ghigo, A; Perino, A; Brewer, AC; Ward, CW; Hirsch, E; Lederer, WJ; Shah, AM

Two distinct calmodulin binding sites in the third intracellular loop and carboxyl tail of angiotensin II (AT(1A)) receptor

Zhang, R; Liu, Z; Qu, Y; Xu, Y; Yang, Q

Valsartan regulates myocardial autophagy and mitochondrial turnover in experimental hypertension

Zhang, X; Li, ZL; Crane, JA; Jordan, KL; Pawar, AS; Textor, SC; Lerman, A; Lerman, LO

Pentoxifylline Ameliorates Cardiac Fibrosis, Pathological Hypertrophy, and Cardiac Dysfunction in Angiotensin II-induced Hypertensive Rats

Zhang, X; Meng, F; Song, J; Zhang, L; Wang, J; Li, D; Li, L; Dong, P; Yang, B; Chen, Y

The angiotensin II type 1 receptor C-terminal Lys residues interact with tubulin and modulate receptor export trafficking

Zhang, X; Wang, H; Duvernay, MT; Zhu, S; Wu, G

miR-29b as a therapeutic agent for angiotensin II-induced cardiac fibrosis by targeting TGF-β/Smad3 signaling

Zhang, Y; Huang, XR; Wei, LH; Chung, AC; Yu, CM; Lan, HY

Activating transcription factor 3 SUMOylation is involved in angiotensin II-induced endothelial cell inflammation and dysfunction

Zhang, ZB; Ruan, CC; Chen, DR; Zhang, K; Yan, C; Gao, PJ

Cardiac protective effects of irbesartan via the PPAR-gamma signaling pathway in angiotensin-converting enzyme 2-deficient mice

Zhang, ZZ; Shang, QH; Jin, HY; Song, B; Oudit, GY; Lu, L; Zhou, T; Xu, YL; Gao, PJ; Zhu, DL; Penninger, JM; Zhong, JC

MicroRNA miR145 regulates TGFBR2 expression and matrix synthesis in vascular smooth muscle cells

Zhao, N; Koenig, SN; Trask, AJ; Lin, CH; Hans, CP; Garg, V; Lilly, B

Essential role of vascular endothelial growth factor in angiotensin II-induced vascular inflammation and remodeling

Zhao, Q; Ishibashi, M; Hiasa, K; Tan, C; Takesh*ta, A; Egashira, K

NADPH oxidase 4 induces cardiac fibrosis and hypertrophy through activating Akt/mTOR and NFκB signaling pathways

Zhao, QD; Viswanadhapalli, S; Williams, P; Shi, Q; Tan, C; Yi, X; Bhandari, B; Abboud, HE

Atg5 deficiency-mediated mitophagy aggravates cardiac inflammation and injury in response to angiotensin II

Zhao, W; Li, Y; Jia, L; Pan, L; Li, H; Du, J

ACE2 overexpression ameliorates left ventricular remodeling and dysfunction in a rat model of myocardial infarction

Zhao, YX; Yin, HQ; Yu, QT; Qiao, Y; Dai, HY; Zhang, MX; Zhang, L; Liu, YF; Wang, LC; Liu, DS; Deng, BP; Zhang, YH; Pan, CM; Song, HD; Qu, X; Jiang, H; Liu, CX; Lu, XT; Liu, B; Gao, F; Dong, B

Notch γ-secretase inhibitor dibenzazepine attenuates angiotensin II-induced abdominal aortic aneurysm in ApoE knockout mice by multiple mechanisms

Zheng, YH; Li, FD; Tian, C; Ren, HL; Du, J; Li, HH

Angiotensin-converting enzyme 2 suppresses pathological hypertrophy, myocardial fibrosis, and cardiac dysfunction

Zhong, J; Basu, R; Guo, D; Chow, FL; Byrns, S; Schuster, M; Loibner, H; Wang, XH; Penninger, JM; Kassiri, Z; Oudit, GY

Multiple genes of the renin-angiotensin system are novel targets of Wnt/β-catenin signaling

Zhou, L; Li, Y; Hao, S; Zhou, D; Tan, RJ; Nie, J; Hou, FF; Kahn, M; Liu, Y

Wnt/β-catenin signaling and renin-angiotensin system in chronic kidney disease

Zhou, L; Liu, Y

Link between the renin-angiotensin system and insulin resistance: implications for cardiovascular disease

Zhou, MS; Schulman, IH; Zeng, Q

Crucial Role of ROCK2-Mediated Phosphorylation and Upregulation of FHOD3 in the Pathogenesis of Angiotensin II-Induced Cardiac Hypertrophy

Zhou, Q; Wei, SS; Wang, H; Wang, Q; Li, W; Li, G; Hou, JW; Chen, XM; Chen, J; Xu, WP; Li, YG; Wang, YP

Endothelial enriched microRNAs regulate angiotensin II-induced endothelial inflammation and migration

Zhu, N; Zhang, D; Chen, S; Liu, X; Lin, L; Huang, X; Guo, Z; Liu, J; Wang, Y; Yuan, W; Qin, Y

Silencing of hypoxia-inducible factor-1α gene attenuated angiotensin II-induced renal injury in Sprague-Dawley rats

Zhu, Q; Wang, Z; Xia, M; Li, PL; Van Tassell, BW; Abbate, A; Dhaduk, R; Li, N

A single mutation in helix 8 enhances the angiotensin II type 1a receptor transport and signaling

Zhu, S; Zhang, M; Davis, JE; Wu, WH; Surrao, K; Wang, H; Wu, G

Genetic analysis of the contribution of LTBP-3 to thoracic aneurysm in Marfan syndrome

Zilberberg, L; Phoon, CK; Robertson, I; Dabovic, B; Ramirez, F; Rifkin, DB

New insights into the structure and function of fatty acid-binding proteins

Zimmerman, AW; Veerkamp, JH

Thirst neurons anticipate the homeostatic consequences of eating and drinking

Zimmerman, CA; Lin, YC; Leib, DE; Guo, L; Huey, EL; Daly, GE; Chen, Y; Knight, ZA

Long-term angiotensin II AT1 receptor inhibition produces adipose tissue hypotrophy accompanied by increased expression of adiponectin and PPARgamma

Zorad, S; Dou, JT; Benicky, J; Hutanu, D; Tybitanclova, K; Zhou, J; Saavedra, JM

Receptor-mediated intrarenal angiotensin II augmentation in angiotensin II-infused rats

Zou, LX; Imig, JD; von Thun, AM; Hymel, A; Ono, H; Navar, LG

hom*ocysteine enhances cell proliferation in vascular smooth muscle cells: role of p38 MAPK and p47phox

Zou, T; Yang, W; Hou, Z; Yang, J

Pivotal Importance of STAT3 in Protecting the Heart from Acute and Chronic Stress: New Advancement and Unresolved Issues

Zouein, FA; Altara, R; Chen, Q; Lesnefsky, EJ; Kurdi, M; Booz, GW

Role of STAT3 in angiotensin II-induced hypertension and cardiac remodeling revealed by mice lacking STAT3 serine 727 phosphorylation

Zouein, FA; Zgheib, C; Hamza, S; Fuseler, JW; Hall, JE; Soljancic, A; Lopez-Ruiz, A; Kurdi, M; Booz, GW

The central renin-angiotensin system and sympathetic nerve activity in chronic heart failure

Zucker, IH; Xiao, L; Haack, KK